<i>Schistosoma mansoni</i> coinfection could have a protective effect against mixed cryoglobulinaemia in hepatitis C patients

Abbas, Omaima M; Omar, Nabil; Zaghla, Hassan; Faramawi, Mohammad F.

doi:10.1111/j.1478-3231.2009.01970.x

Cited by 7 publications

(5 citation statements)

References 43 publications

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“…[25] Considering the subcategory IIc, our study correlated with Abbas, O.M., et al who reported that schistosoma coinfection could have a protective effect against mixed cryoglobulinaemia (CG) [in which renal disease more common than in Type I (CG)] in hepatitis C patients, so less renal impairment. [26] However, in contrary to our study, Kamal, S., et al reported that patients with concomitant HCV and bilharziasis had a marked increase in the Child-Pugh score (more advanced liver disease), more frequent episodes of upper gastrointestinal bleeding, more renal impairment. [24] All these factors not present in our patients (our patients in group II were compensated, no gastrointestinal bleeding, so no renal abnormality found.…”

Section: Discussioncontrasting

confidence: 99%

Neutrophil Gelatinase–associated Lipocalin (Ngal) as an Early Biomarker of Acute Kidney Injury in Hepatic Patients

Kadry

Allah

Ali

et al. 2015

Zagazig University Medical Journal

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Background :Acute kidney injury(AKI) is common in cirrhosis but differential diagnosis remains a challenge. Serum creatinine (SCr) less sensitive in reflecting renal dysfunction in cirrhotic patients. Aim of the Work: to study the usefulness of NGAL as an early biomarker of AKI in cirrhotic patients. Subjects and Methods: 80 subjects included, classified into 3 groups: GroupΙ: 10 control subjects. Group Π (GpΠ): 40 compensated hepatic patients without AKI, further subdivided into four subcategories: (GpΠa1): 10 patients with HCV under interferon plus ribavirin therapy. (GpΠa2): 10 patients with HCV not under interferon or ribavirin therapy. (GpΠb): 10 patients with Bilharzial liver fibrosis. (GpΠc): 10 patients with combined HCV and Bilharzial liver fibrosis. Group Ш (GpШ): 30 decompensated hepatic patients with AKI, further subdivided into three subcategories: (Gp Шa): 10 patients with Acute tubular necrosis. (Gp Шb): 10 patients with hepatorenal syndrome. (Gp Шc): 10 patients with Pre-renal azotemia. All participants were subjected to the routine lab investigations in addition to specific lab test plasma NGAL (pNGAL).Results: No significant difference was found in kidney function parameters (SCr, urea, GFR) between patients with AKI and patients without AKI. However, patients with AKI had higher pNGAL compared to patients without AKI. There were significant difference among group III subcategories, patients with ATN had pNGAL levels markedly higher (mean 295 ng/ml) compared to those of patients with PRA (mean 86.5 ng/ml), Patients with HRS had intermediate values {mean 142 ng/ml}. In patients with ATN, pNGAL markedly rise within 3 hrs of kidney injury compared to SCr which rises after 24 hrs. Among GpΠ subcategories, no significant difference was found in either pNGAL or kidney function parameters. Conclusions: pNGAL is an early biomarker of AKI and it can also discriminate type of AKI in cirrhosis

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Section: Discussioncontrasting

confidence: 99%

Neutrophil Gelatinase–associated Lipocalin (Ngal) as an Early Biomarker of Acute Kidney Injury in Hepatic Patients

Kadry

Allah

Ali

et al. 2015

Zagazig University Medical Journal

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“…Our study detected a lower prevalence of MC among Egyptian patients with cutaneous manifestations of HCV infection (10.169%) than expected. These findings suggest that cryoglobulinaemia in the context of hepatitis C may be less prevalent in Egypt than in other areas and this could be attributed to (1) the apparent protective role of Schistosoma mansoni coinfection, which is common in Egypt, against the development of immune-mediated diseases such as MC in chronic HCV-infected patients [ 26 ]. Helminthic infections are characterized by a strong T helper-2 response as well as an overall downregulated immune system which are both beneficial in protecting the host from developing autoimmune diseases and/or relieving symptoms of an established autoimmune disease [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

“…Some authors had reported that cryoglobulinaemic vasculitis was significantly more common in female population with HCV infection [ 38 ], although this association was nonsignificant in another report [ 39 ]. Abbas et al [ 26 ] reported that cryoglobulinaemia in their Egyptian patients with HCV was not related to age or progression of cirrhosis; meanwhile it was negatively correlated with serum ALT and serum AST levels, and it was positively correlated with female gender. The discrepancy in the results could be due to variation in sample size and inclusion criteria among different studies.…”

Section: Discussionmentioning

confidence: 99%

Cryoglobulinaemia in Egyptian Patients with Extrahepatic Cutaneous Manifestations of Chronic Hepatitis C Virus Infection

Hegab

Sweilam

2015

Dermatology Research and Practice

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Background. Hepatitis C is a global major health problem with extremely variable extrahepatic manifestations. Mixed cryoglobulinaemia (MC) shows a striking association with hepatitis C virus (HCV) infection, and it is sometimes asymptomatic. The skin is a frequently involved target organ in MC. Objective. To investigate the prevalence of cryoglobulinaemia in a sample of Egyptian patients with cutaneous manifestations of chronic HCV infection and to correlate its presence with clinical criteria and liver function tests. Methods. One hundred and eighteen patients with skin manifestations of chronic compensated hepatitis C were included. Venous blood was tested for liver function tests and serum cryoglobulins. Results. Twelve patients (10.169%) were positive for serum cryoglobulins (2 with pruritus, 4 with vasculitic lesions, 3 with livedo reticularis, one with oral lichen, one with chronic urticaria, and another with Schamberg's disease). Vasculitic lesions and livedo reticularis of the legs showed higher prevalence in cryoglobulin-positive than in cryoglobulin-negative patients. Presence of serum cryoglobulins did not relate to patients' demographic or laboratory findings. Conclusions. Fortunately, MC is not markedly prevalent among Egyptians with cutaneous lesions of chronic hepatitis C, and cryopositivity was commonly, but not exclusively, detected with cutaneous vasculitis and livedo reticularis. Laboratory testing for cryoglobulins in every HCV patient is advisable for earlier MC detection and management.

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“…8,9 Previously, Various techniques have been used for decellularization that involves any combination of physical, chemical and enzymatic methods with various solvents, detergent, and enzyme to lyse the cells while creating the free volume spaces upon which native host cells can proliferate. 10 SDS is the most used of the chemical agent in the decellularization process because of their capabilities in cells removal by dissolving the cell membranes. However, it also disrupts the integrity structure of ECM that resulted in weak biomechanical properties of tissues.…”

Section: Introductionmentioning

confidence: 99%

Characterization and in vivo study of decellularized aortic scaffolds using closed sonication system

2019

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Extracellular matrix (ECM) based bioscaffolds prepared by decellularization has increasingly emerged in tissue engineering application because it has structural, biochemical, and biomechanical cues that have dramatic effects upon cell behaviors. Therefore, we developed a closed sonication decellularization system to prepare ideal bioscaffolds with minimal adverse effects on the ECM. The decellularization was achieved at 170 kHz of ultrasound frequency in 0.1% and 2% Sodium Dodecyl Sulphate (SDS) solution for 10 hours. The immersion treatment as control was performed to compare the decellularization efficiency with our system. Cell removal and ECM structure were determined by histological staining and biochemical assay. Biomechanical properties were investigated by the indentation testing to test the stiffness, a residual force and compression of bioscaffolds. Additionally, in vivo implantation was performed in rat to investigate host tissue response. Compared to native tissues, histological staining and biochemical assay confirm the absence of cellularity with preservation of ECM structure. Moreover, sonication treatment has not affected the stiffness [N/mm] and a residual force [N] of the aortic scaffolds except for compression [%] which 2% SDS significantly decreased compared to native tissues showing higher SDS has a detrimental effect on ECM structure. Finally, minimal inflammatory response was observed after 1 and 5 weeks of implantation. This study reported that the novelty of our developed closed sonication system to prepare ideal bioscaffolds for tissue engineering applications.

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Schistosoma mansoni coinfection could have a protective effect against mixed cryoglobulinaemia in hepatitis C patients

Abstract: There is an apparent protective effect of S. mansoni coinfection against mixed cryoglobulinaemia in chronic hepatitis C patients.

Cited by 7 publications

References 43 publications

Neutrophil Gelatinase–associated Lipocalin (Ngal) as an Early Biomarker of Acute Kidney Injury in Hepatic Patients

Neutrophil Gelatinase–associated Lipocalin (Ngal) as an Early Biomarker of Acute Kidney Injury in Hepatic Patients

Cryoglobulinaemia in Egyptian Patients with Extrahepatic Cutaneous Manifestations of Chronic Hepatitis C Virus Infection

Characterization and in vivo study of decellularized aortic scaffolds using closed sonication system

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