<i><scp>COX</scp>‐2</i> gene polymorphisms and risk of chronic periodontitis: a case–control study and meta‐analysis

Prakash, Garima; Umar, Meenakshi; Ajay, Sadhna; Bali, Deepika; Upadhyay, Rohit; Gupta, Kartik; Dixit, Jaya; Mittal, Balraj

doi:10.1111/odi.12203

Cited by 12 publications

(9 citation statements)

References 40 publications

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“…There are no significant associations between polymorphisms in COX-2 gene and periodontitis, as showed in Table 1. Nevertheless, contradicting findings are brought by other authors [8] who found an association between COX-2 and periodontitis in women of northern Indian population [36] and in the population of Northwestern European ethnicity [37]. The substitution of C/G at position −765 and substitution of A/G at position −1195, as well as substitution of C/T at position 8473 in the COX-2, were assumed to be polymorphisms associated with periodontitis [38].…”

Section: Resultsmentioning

confidence: 76%

Genetic Factors and the Risk of Periodontitis Development: Findings from a Systematic Review Composed of 13 Studies of Meta-Analysis with 71,531 Participants

Silva

Carvalho

Alves

et al. 2017

International Journal of Dentistry

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Purpose. This work aimed to synthesize the results of recent meta-analysis focusing on polymorphism in inflammatory mediators and its relation with the risk of periodontitis development. Materials and Methods. A systematic search was conducted using databases for publications prior to October 2016. Three examiners extracted data from articles with a clear association between polymorphisms in the inflammatory mediator gene and the development of periodontitis through meta-analysis using the fixed or randomized statistical models to calculate the Odds Ratio with values of P < 0.05 considered significant. Results. A total of 13 meta-analysis articles with 25 polymorphisms in seven interleukins (IL-1A, IL-1B, IL-4, IL-6, IL-8, IL-10, and IL-18), three cellular receptors (Fcγ receptors: FCGR2A, FCGR3A, and FCGR3B), and five inflammatory mediators (COX-2, MMP-2, MMP-3, MMP-8, and MMP-9), with a total of 71,531 participants, approaching different classifications of the disease. Conclusion. The study demonstrated that polymorphisms in the IL-1A, IL-1B, IL-6, IL-10, MMP-3 (chronic form), and MMP-9 (chronic form) polymorphisms were significantly associated with the risk of developing periodontitis, whereas other polymorphisms in the IL-4, IL-8, IL-18, Fcγ, COX-2, MMP-2, MMP-3 (aggressive), MMP-8, and MMP-9 (aggressive) polymorphisms had no significant association with risk of developing periodontitis.

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Section: Resultsmentioning

confidence: 76%

Genetic Factors and the Risk of Periodontitis Development: Findings from a Systematic Review Composed of 13 Studies of Meta-Analysis with 71,531 Participants

Silva

Carvalho

Alves

et al. 2017

International Journal of Dentistry

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“…Pooled result indicated that a significantly increased risk of the association between the COX2 -765G/C variants and periodontitis in studies with population-based controls and a significantly decreased risk in studies with hospital-based controls was found. Till now, there are only two meta-analyses published on the COX2 -765G/C and periodontitis [ 22 , 23 ], one [ 22 ] paper showed that -765G/C variants could reduce the CP risk in the co-dominant models (GC vs. GG: ORs =0.77, 95% CI = 0.61–0.94) for Asian, while another [ 23 ] paper showed a reduced risk for CP among Chinese population with limited population. Therefore, these two studies were conducted among Chinese populations using smaller number of publications, and did not perform a subgroup analysis by source of controls.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, these two studies were conducted among Chinese populations using smaller number of publications, and did not perform a subgroup analysis by source of controls. Especially for Prakash et al’s meta-analysis [ 23 ], 2 studies performed in Chinese participants were only included, and all the controls were hospital-based. The selection bias would be occurred in hospital-based controls because such populations could not represent the general populations.…”

Section: Discussionmentioning

confidence: 99%

Association between COX2 -765G/C polymorphism and periodontitis in Chinese population: a meta-analysis

Zhan-shan

2018

BMC Oral Health

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BackgroundStudies had attempted to clarify the relation between COX2 -765G/C gene polymorphisms and periodontitis risk, but there has been no definite consensus to date. A meta-analysis was performed to further explore the relationship of COX2 -765G/C polymorphism on periodontitis risk among Chinese population.MethodsThe databases of PubMed, Springer Link, Ovid, Chinese Wanfang Databases, Chinese National Knowledge Infrastructure (CNKI) and Chinese Biology Medicine were searched up to January 2017. The overall result and subgroup analysis results were combined using fixed-effect or random-effect based on the heterogeneity.ResultsFinally, 7 case–control publications including 1399 periodontitis cases and 1663 controls were identified according to the inclusion criteria. In the total analyses, COX2 -765G/C polymorphism had nonsignificant association on periodontitis risk in all models. The subgroup analyses suggested a significantly increased risk of periodontitis in studies with population-based controls and a significantly decreased risk in studies with hospital-based controls.ConclusionsThis meta-analysis indicated that COX2 -765G/C polymorphism had significantly affect on periodontitis risk among Chinese individuals, which should be confirmed by other ethnic groups.

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“…For example, COX-2 promoter SNPs and their haplotypes, can influence susceptibility to various cancers, cardiovascular disease, Parkinson's disease, and viral hepatitis C infections [19][20][21][22][23]. Meta-analyses on some of the more commonly explored COX-2 promoter SNPs show that the COX-2 (−765 G > C) polymorphism is associated with the risk of prostate cancer, coronary artery disease, and chronic periodontitis [24][25][26], whereas variation at COX-2 (−1195 A > G) can influence susceptibility to hepatocellular carcinoma and other cancers [27,28]. Meta-analyses of COX-2 haplotypes (−765 G > C and −1195 A > G) also reveal that these haplotypes alter susceptibility to gastric, esophageal, and breast cancers, and Alzheimer's disease [29][30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Cyclooxygenase-2 haplotypes influence the longitudinal risk of malaria and severe malarial anemia in Kenyan children from a holoendemic transmission region

et al. 2019

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Cyclooxygenase-2 [(COX-2) or prostaglandin endoperoxide H2 synthase-2 (PTGS-2)] induces the production of prostaglandins as part of the host-immune response to infections. Although a number of studies have demonstrated the effects of COX-2 promoter variants on autoimmune and inflammatory diseases, their role in malaria remains undefined. As such, we investigated the relationship between four COX-2 promoter variants (COX-2 −512 C > T, −608 T > C, −765 G > C, and −1195 A > G) and susceptibility to malaria and severe malarial anemia (SMA) upon enrollment and longitudinally over a 36-month follow-up period. All-cause mortality was also explored. The investigation was carried out in children (n = 1081, age; 2-70 months) residing in a holoendemic Plasmodium falciparum transmission region of western Kenya. At enrollment, genotypes/haplotypes (controlling for anemia-promoting covariates) did not reveal any strong effects on susceptibility to either malaria or SMA. Longitudinal analyses showed decreased malaria episodes in children who inherited the −608 CC mutant allele (RR = 0.746, P = 1.811 × 10 −4 ) and −512C/−608T/−765G/−1195G (CTGG) haplotype (RR = 0.856, P = 0.011), and increased risk in TTCA haplotype carriers (RR = 1.115, P = 0.026). Over the follow-up period, inheritance of the rare TTCG haplotype was associated with enhanced susceptibility to both

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COX‐2 gene polymorphisms and risk of chronic periodontitis: a case–control study and meta‐analysis

Cited by 12 publications

References 40 publications

Genetic Factors and the Risk of Periodontitis Development: Findings from a Systematic Review Composed of 13 Studies of Meta-Analysis with 71,531 Participants

Genetic Factors and the Risk of Periodontitis Development: Findings from a Systematic Review Composed of 13 Studies of Meta-Analysis with 71,531 Participants

Association between COX2 -765G/C polymorphism and periodontitis in Chinese population: a meta-analysis

Cyclooxygenase-2 haplotypes influence the longitudinal risk of malaria and severe malarial anemia in Kenyan children from a holoendemic transmission region

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