<i><scp>IL</scp>1</i> gene polymorphisms in relation to external apical root resorption concurrent with orthodontia

Linhartová, Petra Bořilová; Černochová, Pavlína; Hollá, Lýdie Izakovičová

doi:10.1111/j.1601-0825.2012.01973.x

Cited by 47 publications

(54 citation statements)

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“…27,28 Interleukin 1 is one of the first cytokines implicated in inflammation of the vessel wall during tooth movement, affecting leucocyte recruitment and transmigration. [29][30][31][32][33] Closely connected to this, the function of interleukin 1 is antagonized by the IL1ra protein encoded in the IL1RN gene, wherein specific sequence variants have been associated with an increased predisposition to suffer OIEARR. 11,32 In this connection, subjects homozygous for the T allele of the IL1RN variant studied here may be prone to imbalances in cytokine levels on the IL1ra/IL1b axis during orthodontic tooth movement, which may be associated with a decreased bone remodeling rate that directly influences the subsequent increase in radicular stress.…”

Section: Discussionmentioning

confidence: 99%

“…[29][30][31][32][33] Closely connected to this, the function of interleukin 1 is antagonized by the IL1ra protein encoded in the IL1RN gene, wherein specific sequence variants have been associated with an increased predisposition to suffer OIEARR. 11,32 In this connection, subjects homozygous for the T allele of the IL1RN variant studied here may be prone to imbalances in cytokine levels on the IL1ra/IL1b axis during orthodontic tooth movement, which may be associated with a decreased bone remodeling rate that directly influences the subsequent increase in radicular stress. Failure to identify the DNA information of each subject means failing to include the risk inherent in certain patient genotypes, which leads to misinterpreting the observed results of the appliance's effect on OIEARR.…”

Section: Discussionmentioning

confidence: 99%

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Orthodontically induced external apical root resorption in patients treated with fixed appliances vs removable aligners

Iglesias-Linares

Sonnenberg

Beatriz

et al. 2016

The Angle Orthodontist

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Objective: To determine whether orthodontic treatment with removable aligners vs fixed orthodontic appliances is associated with a different frequency of orthodontically induced external apical root resorption (OIEARR) when genetic, radiographic, and clinical factors are accounted for. Materials and Methods: Three hundred seventy-two orthodontic patients treated with removable aligners (Invisalign) or fixed appliances were genetically screened for interleukin 1B gene (IL1B) (rs1143634), interleukin 1 receptor antagonist gene (IL1RN) (rs419598), and osteopontin gene (SPP1) (rs9138/rs11730582). Twelve clinical variables, potentially associated with OIEARR, were also considered. Subjects were divided according to the presence of radiographically determined OIEARR (.2 mm). The association between OIEARR and appliance type, and radiographic, clinical and genetic factors, was assessed using backward stepwise conditional logistic regression. Odds ratios (ORs) and 95% confidence intervals (CIs) were reported. Results: Reliability of the methods was adequate. Clinical case complexity (American Board of Orthodontics [ABO] Discrepancy Index) (OR: 1.032; 95% CI: 1.005-1.061; P ¼ .021) and extent of incisor apical displacement in the sagittal plane (OR: 1.478; 95% CI: 1.285-1.699; P ¼ .001) were associated with an increased OIEARR risk. After adjusting for associations between clinical/ radiographic/genetic factors, there were no statistically significant differences with respect to OIEARR or type of orthodontic appliance used, whether removable aligners or fixed appliances (OR: 1.662; 95% CI: 0.945-2.924; P ¼ .078). Only subjects homozygous for the T allele of IL1RN (rs419598) were more prone to OIEARR during orthodontic treatment (OR: 3.121; CI: 1.93-5.03; P , .001). Conclusions: A similar OIEARR predisposition was identified using either removable aligners (Invisalign) or fixed appliances. (Angle Orthod. 2017;87:3-10)

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Orthodontically induced external apical root resorption in patients treated with fixed appliances vs removable aligners

Iglesias-Linares

Sonnenberg

Beatriz

et al. 2016

The Angle Orthodontist

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“…Del mismo modo Linhartova et al (2013) no logró establecer asociación entre el polimorfismo del gen IL-1B y la RRE en pacientes con ortodoncia.…”

Section: Discussionunclassified

Polimorfismo (+3954C>T) del Gen IL-1B y su Asociación con la Resorción Radicular Apical Externa Post-Tratamiento Ortodóntico

Vides

Salcedo

Tirado

et al. 2016

Int. J. Odontostomat.

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RESUMEN:El objetivo fue determinar la presencia del polimorfismo rs1143634 (+3954C>T) del gen Interleuquina 1 Beta (IL-1B) y su asociación con la resorción radicular apical externa (RRE) post-tratamiento ortodóntico. Se realizó un estudio piloto de individuos tratados con aparatología ortodontica, 13 (casos) presentaron RRE posterior al tratamiento ortodóntico y 22 (controles) estaban clínicamente sanos. A partir de muestras de células epiteliales de mucosa bucal se extrajo ADN y se genotipificó el polimorfismo rs1143634 (+3954C>T) del gen IL-1B mediante la reacción en cadena de la polimerasa y digestión del producto con la enzima de restricción TaqI. Se estimaron las frecuencias alélicas y genotípicas del rs1143634; además, se evaluó la desviación del equilibrio de Hardy-Weinberg. Las frecuencias alélicas y genotípicas se compararon mediante la prueba de c2 con razón de verosimilitud (p <0,05). El promedio de edad de los participantes fue 28,1 (DE=11,5) años y el 68,6 % era mujeres. Al comparar la distribución de los genotipos del polimorfismo IL-1B (+3954C>T) entre grupos no se encontró una diferencia estadísticamente significativa (p=0,0926). Sin embargo, se observó una diferencia significativa en la distribución de alelos (p= 0,035), siendo el alelo T (alelo 2) más prevalente en el grupo control. El polimorfismo IL-1B (+3954C>T) se encontró presente en la población de estudio. Aunque no existieron diferencias en la distribución de los genotipos que apoyara una asociación entre este polimorfismo y la RRE, si hubo una diferencia en la distribución de los alelos, sugiriendo que el alelo T posiblemente actúa como factor protector contra el desarrollo de la RRE.PALABRAS CLAVE: reabsorción radicular externa, reabsorción apical, interleuquina 1 beta. INTRODUCCIÓNEn la actualidad el tratamiento de ortodoncia es uno de los servicios especializados más solicitados en la práctica odontológica, debido a la capacidad que tiene de proporcionar funcionalidad oclusal y estética facial. Durante y luego de este tratamiento comúnmen-te se puede observar un remodelado apical de los dientes, el cual es considerado como una respuesta fisiológica adaptativa; sin embargo algunas veces por causas aún desconocidas se puede presentar la reabsorción radicular externa (RRE), entidad patoló-gica asociada a un proceso de inflamación crónico en donde existe una pérdida mayor de 2 mm de cemento y dentina en la parte externa de la raíz (Ahangari et al., 2010;Diouf et al., 2015).

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“…The results of the present review suggest that although some authors have reported that genetic polymorphism may play a role in EARR, [4][5][6][7][8][9][20][21][22][23]24 others have not supported this association. [25][26] Published orthodontic investigations in gene studies have seldom adhered to the STREGA or any genetic guidelines. As a result, the study may suffer from methodological inaccuracies, which can introduce bias.…”

Section: Summary Of Evidencementioning

confidence: 99%

Association of genetic polymorphism and external apical root resorption

Aminoshariae

Valiathan

et al. 2016

The Angle Orthodontist

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Objective: To evaluate the relationship between genetic polymorphism and external apical root resorption. Methodology: The protocol was prepared and registered on PROSPERO. Two reviewers independently conducted a comprehensive literature search. The MEDLINE, Embase, Cochrane, and PubMed databases were searched. In addition, the bibliographies of all relevant articles and textbooks were manually searched. Results: Thirteen studies met the inclusion criteria. Four studies were classified as low-quality studies (score ,10), and nine studies were classified as high-quality studies. Discussion: The results of the present review suggest that, although some authors have reported that genetic polymorphism may play a role in external apical root resorption, others have not supported this association. Future studies should be more consistent in their research methodologies to determine with clarity whether an association exists. Conclusion: Future investigations should include larger sample sizes with matching cases/ controls, adjust for confounders, provide power calculation and odds ratios, and report genetic analyses with the Hardy-Weinberg equilibrium. The current investigation suggests guidelines and recommendations for future investigators studying genetic polymorphism in patients undergoing orthodontic treatment. (Angle Orthod. 2016;86:1042-1049

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IL1 gene polymorphisms in relation to external apical root resorption concurrent with orthodontia

Abstract: Although no significant role of IL1A (-889C/T) and IL1B (+3953C/T) variants in EARR was confirmed, IL1RN VNTR may be associated with EARR, especially in girls.

Cited by 47 publications

References 46 publications

Orthodontically induced external apical root resorption in patients treated with fixed appliances vs removable aligners

Orthodontically induced external apical root resorption in patients treated with fixed appliances vs removable aligners

Polimorfismo (+3954C>T) del Gen IL-1B y su Asociación con la Resorción Radicular Apical Externa Post-Tratamiento Ortodóntico

Association of genetic polymorphism and external apical root resorption

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