Although no significant role of IL1A (-889C/T) and IL1B (+3953C/T) variants in EARR was confirmed, IL1RN VNTR may be associated with EARR, especially in girls.

The aims of this retrospective computed tomography (CT) study were to determine the occurrence of severe root resorption involving the pulpal canal of adjacent permanent teeth associated with ectopically erupting canines, and to verify the existence of related factors. The sample consisted of 255 consecutive patients (159 females and 96 males, mean age 18.4 and 16.8 years, respectively). Three hundred and thirty-four ectopic maxillary canines and adjacent teeth were analysed using CT images. Statistical significance was evaluated with chi-square and Fisher's exact tests. The results showed that severe root resorption of adjacent permanent teeth occurred in 17.7 per cent of ectopic canines and was equally common in females and males. Severe root resorption affected 12.6 per cent of the lateral incisors, 4.8 per cent of the first premolars, and 2.1 per cent of the central incisors. No relationship was found between the type or side of ectopic eruption, inclination of the longitudinal axis of the ectopic canine and the occurrence of severe root resorption. A significant relationship was found between a bucco-lingual position of the ectopic canine and root resorption (P < 0.05). Root resorption mainly occurred in the apical third (57.6 per cent) and apical and middle thirds (27.1 per cent). A significant relationship existed between the occurrence of root resorption and complete loss of space for the erupting canine (P < 0.05). No association was found between alignment of the upper permanent incisor and root resorption. A widened dental follicle occurred in 15 per cent of ectopic canines but did not cause root resorption of the adjacent permanent teeth. Since root resorption is asymptomatic, early detection by radiographic examination is essential for correct diagnosis and treatment.

The aim of this retrospective study was to analyse dentoskeletal characteristics in patients with eruption disturbances of the maxillary permanent canines. Pre-treatment panoramic radiographs and lateral cephalograms of 636 consecutive orthodontic patients were assessed. The control group included 456 patients with physiologically erupted maxillary permanent canines (261 females and 195 males, mean age 12.6 and 12.4 years, respectively). The other groups comprised 144 subjects with palatally displaced canines (PDCs) (92 females and 52 males, mean age 14.2 and 14.7 years, respectively) and 36 patients with buccally displaced canines (BDCs) (16 females and 20 males, mean age 12.4 and 12.8 years, respectively). The selected dentoskeletal parameters were compared with classic cephalometric norms using the method of analysis of variance, chi-square, and Fisher's exact tests. The PDC patients showed a significantly more prognathic maxilla, a significantly more frequent occurrence of skeletal class I, retroinclination of maxillary central incisors, hypodivergent relationship, and mandibular anteriorotation and less frequent posteriorotation. A significantly more frequent retrognathic maxilla and skeletal class III and less frequent retroinclination of the maxillary central incisors were found in the BDC patients. The results of this study indicate the existence of different facial morphology and more likely also etiopathogenesis of eruption disturbances of the canines in the PDC and BDC patients.

Although the effect of individual SNPs studied on the EARR development was not confirmed in the Czech population, complex analysis suggested that variability in the P2RX7 gene and the length of orthodontic treatment may be important factors contributing to the etiopathogenesis of postorthodontic EARR.