IRS1‐ rs10498210 G/A and CCR5‐59029 A/G polymorphisms in patients with type 2 diabetes in Kurdistan

Abstract

Background The insulin receptor substrate 1 ( IRS 1 ) is a critical factor in the signaling pathway for insulin, and mutations in this gene have been reported, which contribute to the ability to develop type 2 diabetes. The polymorphisms in the promoter region of C‐C motif chemokine receptor5 ( CCR 5 ) are also being studied as candidates for susceptibility to develop type 2 diabetes. The aim of the current study was to determine the relationship between IRS 1 and CCR 5 polymorphisms with type 2 diabetes in the Kurdistan population. Methods Genomic DNA was isolated from the blood by salt extraction method and the polymorphisms were examined using Restriction Fragment Length Polymorphism ( RFLP ) method. Results The results of current study indicated that the frequency of AA genotype in type 2 diabetic patients in both CCR 5 ( OR = 2.9, p = 0.04) and IRS 1 ( OR = 3.3, p = 0.036) were significantly more than controls. Conclusion According to the results of this study, the presence of AA genotype in both CCR 5 and IRS 1 is associated with type 2 diabetes. There was no significant association between AG or GG genotypes with type 2 diabetes.

β Cell dysfunction during progression of metabolic syndrome to type 2 diabetes

“…For example, deletion of the insulin and IGF-1 receptors from β cells or manipulation of IRS1/2 and AKT isoforms in mice triggers insulin resistance and, in some instances, diabetes (29,(45)(46)(47)(48). Furthermore, mutations in IRS1 have been linked to β cell dysfunction and association with T2DM in several human populations (49,50). Regardless of the initiating event, there is considerable evidence that increased functional capacity is an essential component of β cell adaptation in MetS that is triggered to delay and/or prevent progression to diabetes.…”

Nutrigenomics in Regulating the Expression of Genes Related to Type 2 Diabetes Mellitus

“…The PI3KR1 gene encodes a phosphoinositide-3-kinase regulatory subunit 1 enzyme with direct function in the insulin signaling pathway ( Karadoğan et al, 2018 ). The IRS1 gene encodes the insulin receptor substrate-1, which after phosphorylate regulates growth cascades, metabolism, and glucose transporter ( Keshavarzi and Golsheh, 2019 ). The FFAR1 gene carries the code for the formation of the Free fatty acid receptor 1 protein (Ffar1).…”