<i>Sesame indicum</i>, a nutritional supplement, elicits antiamnesic effect via cholinergic pathway in scopolamine intoxicated mice

Chidambaram, Saravana Babu; Pandian, Anbarasi; Sathiya, S.; Sumathy, Haridass; Ranju, Vijayan; Thiyagarajan, Lakshmi Kantham; Jayasree, R.; Raghavendran, Hanumantha Rao Balaji; Kamarul, Tunku

doi:10.1002/tox.22196

Cited by 4 publications

(4 citation statements)

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“…Our results are in parallel with that found by [5] who declared the negative effect of high fat diet which affects oxidative stress. Same results were found by [6] who noted that high fat diet even for short duration affect potentially brain function. Sesame oil acts as magic ingredient that prevents brain damage.…”

Section: Bdc=basal Diet Control Lsd=least Significant Differencesupporting

confidence: 77%

“…Based on our previous findings, Baked cake was produced and evaluated from sesame oil (5 g sesame oil/ 30 g one serving) and fortified with orange peel as a functional food for brain injury. Chemical analysis of cake was showed in table (6) from this table it could be noticed that carbohydrate content was 42.8% while protein was 12.2% and fat 13%. Fig ( 10) statistical analysis of sensory evaluation.…”

Section: Bdc=basal Diet Control Lsd=least Significant Differencementioning

confidence: 99%

“…Vegetable shortening contain a very high proportion of saturated with respect to unsaturated fat, thus called highly saturated fat High saturated fat cause many health problems and affect brain in both human and animal models [3], such effect is due to the increase of oxidative stress after consuming H.F.D [4,5]. It was demonstrated that feeding H.F.D even for short duration [6] caused negative impairment in both learning and behavioural functions. It was proved that the high intake of saturated fats decrease Apo lipoprotein E which lead to losing amyloid Beta protein and plaques formation that interfere with neuron function as occurring in Alzheimer's patients.…”

Section: Introductionmentioning

confidence: 99%

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The promising effect of some essential oils on the brain health : Biochemical and pathological study

2022

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The brain is the most complex and important organs that control all the body functions. Quantity and quality of fat consumed play an important role in maintaining brain health, thus affect brain functions. The aim of this study was to assess the harmful effect of high intake of unhealthy source of fat as well as to detect the role of healthy oils on brain function from chemical and histological point of view. This study was conducted on (56) adult male rats divided into two major groups: the first was normal diet group ND (fed normal diet) that include 4 subgroups (7 rats each group) the first served as control with corn oil as fat source while in the other (3) groups corn oil was substituted by sesame, flaxseed and chia oils. The second major group was high fat diet group divided into 4 subgroups fed high fat diet (H.F. D ,13% oil + 7% vegetable shortening). In high fat control group oil used was corn oil while in the remaining (3) groups corn oil was substituted by sesame, flaxseed and chia oils. After 6 weeks' brain was separated for biochemical analysis of neurotransmitters and oxidative stress. Samples were also prepared for histological examination. Experimental oils were also used in the preparation of salad and cake that help maintaining healthy brain. Chemical analysis and sensory evaluation were conducted for those products. Our results revealed that diet rich in corn oil and vegetable shortening (rich in high saturated fatty acid) caused disturbances in both neurotransmitters and oxidative stress. Damage was also detected in histological sections from brain cortex. It is worthy to mention that using sesame, flaxseed and chia oils instead of corn oil had a protective effect on brain. In addition, those oils were highly acceptable in our products. It could be concluded that adding those healthy oils to daily meals could have a protective effect on brain injury.

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Section: Bdc=basal Diet Control Lsd=least Significant Differencesupporting

confidence: 77%

Section: Bdc=basal Diet Control Lsd=least Significant Differencementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The promising effect of some essential oils on the brain health : Biochemical and pathological study

2022

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“…Thus, the SD had a positive effect and the HFD had a negative effect on memory. Some studies have demonstrated that the HFD, even for a short period of life can potentially disrupt a number of behavioral tests of learning and memory, while sesame seed extract reduced acetylcholinesterase activity and the level of BAX and caspase3 [47]. Thus, the results are inconsistent due to the differences in research designs, and length of HFD exposure during critical periods of development, speci c types of fatty acids, and gender [48].…”

Section: The Comparison Of the Levels Of Mda Tos Tac And Thiol In Dif...mentioning

confidence: 99%

Sesame oil affect learning and memory impairment, anxiety and biomarkers of oxidative stress in rats with a long-term high-fat diet consumption

Rustaei

Sadeghian

Salehi

et al. 2023

Preprint

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Nowadays, high-fat foods are eaten in most societies, which causes memory impairment and anxiety through the oxidative stress pathway. Sesame oil (SO) has potential antioxidant properties. The hypothesis of this study was that sesame oil affect memory impairment and anxiety caused by a high-fat diet (HFD) in male rats. Eighty male Wistar rats were divided into eight groups (n = 10): control (standard diet; SD), the HFD, SD + SO (0.5, 1, or 2 ml/kg; once/day, gavage), and HFD + SO (0.5, 1, or 2 ml/kg; once/day, gavage) groups. All diets were given to the animals for three months. Finally, behavioral and oxidative stress parameters were measured. The step-through latency of retention test in SD + SO (0.5 or 1 ml/kg) groups increased more than the control group. Also, the Barnes test on training days revealed that the latency time to find the target hole increased in the HFD group compared with the control group. Moreover, the time spent on the open arms in the SD + SO (0.5 ml/kg) group improved remarkably than the control group. Total oxidant (TOS) level in the HFD + SO (0.5, 1, and 2 ml/kg) groups was lower than the HFD group. The level of total antioxidant capacity (TAC) in the SD + SO (2 ml/kg) group was higher than the SD + SO (0.5 ml/kg) group and the amount of thiol in the HFD group decreased compared with the control group. These findings suggest that the positive effects of SO on memory and anxiety are probably due to its antioxidant properties and the elimination of free radicals.

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Food and nutraceutical functions of sesame oil: An underutilized crop for nutritional and health benefits

et al. 2022

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Sesame indicum, a nutritional supplement, elicits antiamnesic effect via cholinergic pathway in scopolamine intoxicated mice

Abstract: Sesame seeds have the ability to interact with cholinergic components involved in memory function/restoration and also an interesting candidate to be considered for future cognitive research. © 2015 Wiley Periodicals, Inc. Environ Toxicol 31: 1955-1963, 2016.

Cited by 4 publications

References 42 publications

The promising effect of some essential oils on the brain health : Biochemical and pathological study

The promising effect of some essential oils on the brain health : Biochemical and pathological study

Sesame oil affect learning and memory impairment, anxiety and biomarkers of oxidative stress in rats with a long-term high-fat diet consumption

Food and nutraceutical functions of sesame oil: An underutilized crop for nutritional and health benefits

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