<i>Shigella dysenteriae</i>Serotype 1, Kolkata, India

Dutta, Shanta; Dutta, D; Dutta, P; Matsushita, Shigeru; Bhattacharya, Sujit; Yoshida, Shigeaki

doi:10.3201/eid0911.020652

Cited by 44 publications

(36 citation statements)

References 12 publications

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“…S. dysenteriae type 1 causes endemic and epidemic shigellosis, characterized by high fever, cramps, seizures, bloody diarrhea and dysentery, hemolytic uremic syndrome, and death. Although shigellosis caused by S. dysenteriae type 1 is rare in developed countries, it is a frequent cause of disease in the developing world (2)(3)(4). It is estimated that from 1966 to 1997, Ϸ160 million cases of shigellosis occurred worldwide, with more than one million fatalities (5).…”

mentioning

confidence: 99%

Effect of the nonreducing end of Shigella dysenteriae type 1 O-specific oligosaccharides on their immunogenicity as conjugates in mice

Pozsgay

Kübler-Kiełb

Schneerson

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

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confidence: 99%

Effect of the nonreducing end of Shigella dysenteriae type 1 O-specific oligosaccharides on their immunogenicity as conjugates in mice

Pozsgay

Kübler-Kiełb

Schneerson

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

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“…However, because of excessive use of antibiotics, emergence of multi-drug-resistant species of Shigella has accelerated (2). Shigella is a facultative intracellular pathogen but cannot invade intestinal epithelial cells through the apical surface (3).…”

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confidence: 99%

Improved outcome in shigellosis associated with butyrate induction of an endogenous peptide antibiotic

Raqib

Sarker

Bergman

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

265

198

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Shigella is a major cause of morbidity, mortality, and growth retardation for children in developing countries. Emergence of antibiotic resistance among Shigellae demands the development of effective medicines. Previous studies found that the endogenous antimicrobial peptide LL-37 is down-regulated in the rectal epithelium of patients during shigellosis and that butyrate upregulates the expression of LL-37 in colonic epithelial cells in vitro and decreases severity of inflammation in experimental shigellosis. In this study, Shigella-infected dysenteric rabbits were treated with butyrate (0.14 mmol͞kg of body weight) twice daily for 3 days, and the expression levels of the rabbit homologue to LL-37, CAP-18, were monitored in the colon. Butyrate treatment resulted in (i) reduced clinical illness, severity of inflammation in the colon, and bacterial load in the stool, (ii) significant up-regulation of CAP-18 in the surface epithelium, and (iii) disappearance of CAP-18-positive cells in lamina propria. The active CAP-18 peptide was released in stool from its proform by butyrate treatment. In healthy controls, CAP-18 expression was localized predominantly to the epithelial surface of the colon. In infected rabbits, CAP-18 expression was localized to immune and inflammatory cells in the colon, whereas the ulcerated epithelium was devoid of CAP-18 expression. The combination of CAP-18 and butyrate was more efficient in killing Shigella in vitro than CAP-18 alone. Our findings indicate that oral butyrate treatment in shigellosis may be of clinical value because of induction of the endogenous cathelicidin CAP-18 in the colonic epithelium, stimulation of the release of the active peptide CAP-18, and promoting elimination of Shigella.antimicrobial peptides ͉ CAP-18 ͉ cathelicidin ͉ colon ͉ Shigella

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“…dysenteriae type 1 [10][11][12][13][14][15][16][17][18][19][20][21]. Shigellosis is known to be associated with many complications, e.g.…”

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confidence: 99%

Shigellosis in a Newborn---An Uncommon Case

Khan¹

2017

IJBECS

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Abstract:A new born baby was admitted to the Glocal hospital, Krishnanagore, and presented with loose stools mixed with blood and mucous and abdominal distension for last five days. The baby was crying all through the day; presumably, he had severe tenesmus (a feeling of incomplete sense of defecation with rectal pain). He was diagnosed, clinically, to be suffering from shigellosis, which was confirmed by isolation of Shigella spp; by stool culture. The baby recovered with antibiotic treatment. It is an uncommon case of shigellosis in new born babies. Hand washing practices are recommended to prevent transmission of shigellosis and other diseases as well. Shigellae vaccines are attractive disease prevention strategy. Shigellosis caused by S. flexneri type 2 and S. dysenteria type 1 are the two most common and important serotype candidates against which vaccine development are currently being directed.

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Shigella dysenteriaeSerotype 1, Kolkata, India

Cited by 44 publications

References 12 publications

Effect of the nonreducing end of Shigella dysenteriae type 1 O-specific oligosaccharides on their immunogenicity as conjugates in mice

Effect of the nonreducing end of Shigella dysenteriae type 1 O-specific oligosaccharides on their immunogenicity as conjugates in mice

Improved outcome in shigellosis associated with butyrate induction of an endogenous peptide antibiotic

Shigellosis in a Newborn---An Uncommon Case

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