<i>SLC11A1</i> and <i>VDR</i> gene variants and susceptibility to tuberculosis and disease progression in East India

Singh, Anamika; Jp, Gaughan; Vk, Kashyap

doi:10.5588/ijtld.11.0089

Cited by 35 publications

(24 citation statements)

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“…Deviation from HWE among controls implies potential bias during control selection or might be due to genotyping errors; however, excluding studies deviating from HWE did not affect our VDR polymorphism association results (Ates et al, 2011;Singh et al, 2011;Joshi et al, 2014), except for those related to the TaqI polymorphism in South Asians. It was difficult to correlate publication bias with the funnel plot, which is usually used to detect publication bias, as the number of studies included in the analysis was relatively small.…”

Section: Heterogeneity Subgroup Analysis and Publication Biasmentioning

confidence: 90%

“…Multiple studies have examined the potential contribution made by VDR polymorphisms to PTB susceptibility, but the findings of these studies have been contradictory (Bellamy et al, 1999;Wilkinson et al, 2000;Delgado et al, 2002;Bornman et al, 2004;Liu et al, 2004;Roth et al, 2004;Chen et al, 2006;Babb et al, 2007;Olesen et al, 2007;Søborg et al, 2007;Banoei et al, 2010;Ates et al, 2011;Singh et al, 2011;Joshi et al, 2014). Individual studies based on small sample sizes have insufficient statistical power to detect positive associations and are incapable of demonstrating the absence of an association.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, a total of 16 relevant studies were considered in this meta-analysis (Bellamy et al, 1999;Wilkinson et al, 2000;Delgado et al, 2002;Bornman et al, 2004;Liu et al, 2004;Roth et al, 2004;Chen et al, 2006;Babb et al, 2007;Olesen et al, 2007;Søborg et al, 2007;Merza et al, 2009;Selvaraj et al, 2009;Banoei et al, 2010;Ates et al, 2011;Singh et al, 2011;Joshi et al, 2014), comprising 3231 patients and 3670 controls in total (Table 1 and Figure 1). These 16 studies encompassed 5 studies from Africa, 4 from South Asia, 3 from the Middle East, 2 from East Asia, 1 from Southeast Asia, and 1 from South America.…”

Section: Studies Included In the Meta-analysismentioning

confidence: 99%

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Vitamin D receptor gene FokI, TaqI, BsmI, and ApaI polymorphisms and susceptibility to pulmonary tuberculosis: a meta-analysis

Lee

Song

2015

Genet. Mol. Res.

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ABSTRACT. The aim of this study was to determine whether vitamin D receptor (VDR) genetic polymorphisms are associated with the susceptibility to pulmonary tuberculosis (PTB). MEDLINE and Embase databases and manual literature searches were used. A meta-analysis was conducted on the associations between the VDR FokI, TaqI, BsmI, and ApaI polymorphisms and PTB susceptibility. A total of 16 studies comprising 3231 patients and 3670 controls met the study inclusion criteria, consisting of 14 studies on the VDR FokI polymorphism, 13 on the VDR TaqI polymorphism, 8 on the VDR BsmI polymorphism, and 5 on the VDR ApaI polymorphism. Meta-analysis of the VDR FokI polymorphism showed no association between PTB and the f allele of the VDR FokI polymorphism (long variant) in all subjects (OR = 1.070, 95%CI = 0.979-1.169, P = 0.134). In contrast, after stratification by ethnicity, meta-analysis indicated that the VDR FokI F allele (short variant) was associated with PTB risk in an East Asian population (OR = 1.507, 95%CI = 1.192-1.906, P = 0.001). Meta-analysis revealed no association between PTB susceptibility and the VDR TaqI t allele in all study subjects (OR = 0.986, 95%CI = 0.839-1.159, P = 0.866) 9119 VDR polymorphisms and tuberculosis ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (3): 9118-9129 (2015) or in individual ethnic populations. Furthermore, a risk of PTB was not associated with the BsmI and ApaI polymorphisms. This metaanalysis suggested that the VDR FokI polymorphism is associated with a susceptibility to PTB in East Asians.

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Section: Heterogeneity Subgroup Analysis and Publication Biasmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Section: Studies Included In the Meta-analysismentioning

confidence: 99%

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Vitamin D receptor gene FokI, TaqI, BsmI, and ApaI polymorphisms and susceptibility to pulmonary tuberculosis: a meta-analysis

Lee

Song

2015

Genet. Mol. Res.

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“…Also, a meta-analysis from 13 studies also confirmed the association between the ff genotype of FokI polymorphism with TB [26]. There is no correlation found between BsmI polymorphism of the VDR gene and TB in studies from Africa [19,30] and Asia including India [27] and Korea [25]. Other studies from Asia, including Iran [28] and Turki [29], and from Africa [30] showed that the bb genotype was a protective factor towards TB, while in another study, the bb genotype correlated to the susceptibility to TB in Iran [17,31].…”

Section: Discussionmentioning

confidence: 58%

Is There Any Impact of VDR Gene Polymorphism in Bataks Ethnic to Have Tuberculosis?

Siregar¹,

Sinaga²

2017

JHS

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Abstract:The active metabolite of vitamin D activates macrophages and results in the restriction of growth of Tuberculosis (TB) pathogen M. tuberculosis. The effect of vitamin D is achieved through binding to the Vitamin D Receptor (VDR), which ultimately produces the antimicrobial peptide Cathelicidin. Matched case-control study with 76 pulmonary tuberculosis Indonesian Batak ethnic patients and 76 healthy normal control were completed. Genetic polymorphisms of VDR gene were analysed using PCR and RFLP. The genotype frequencies of ApaI were AA 10.6%, Aa 44.7%, aa 44.7% for the control group and AA 10.6%, Aa 43.4%, aa 46% for the PTB patients. For the FokI genotype the frequencies were FF 39.5%, Ff 44.7%, ff 15.8% for the control group and FF 35.5%, Ff 55.3%, ff 9.2% for the PTB patients. In these two genotypes there were no significant differences found between the control group and the PTB patients (P > 0.05). Besides, there genotypic frequencies were in agreement with the Hardy-Weinberg Equilibrum (P > 0.05). However, for the BsmI genotype frequencies, BB 2.6%, Bb 23.7% and bb 73.7% for the control group and BB 0%, Bb 68.4%, bb 31.6% for the PTB patients, there was a significant association found with PTB; the bb genotype is correlated with a decreased risk for PTB (OR 0.22, 95% CI: 0.11-0.45). ApaI and FokI polymorphisms of VDR gene do not appear to be responsible for host susceptibility to pulmonary tuberculosis in the Indonesian Batak ethnic population but BsmI polymorphism had association with host resistant to PTB.

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“…Base on the inclusion criteria, 18 case-control studies with full-text were included in this meta-analysis (Wilkinson et al, 2000;Bornman et al, 2004;Liu et al, 2004;Roth et al, 2004;Lombard et al, 2006;Babb et al, 2007;Olesen et al, 2007;Soborg et al, 2007;Alagarasu et al, 2009;Merza et al, 2009;Selvaraj et al, 2003Selvaraj et al, , 2004Selvaraj et al, , 2009Zhang et al, 2010;Ates et al, 2011;Singh et al, 2011;Rathored et al, 2012;Joshi et al, 2014). These 18 case-control studies included a to tal of 3160 tuberculosis cases and 3619 healthy controls.…”

Section: Study Characteristicsmentioning

confidence: 99%

Vitamin D receptor FokI gene polymorphism and tuberculosis susceptibility: a meta-analysis

Sun¹,

Cai²

2015

Genet. Mol. Res.

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ABSTRACT. Numerous studies have evaluated the association between FokI polymorphisms in the vitamin D receptor (VDR) gene and tuberculosis risk. However, the spe cific association remains controversial. In this study, we performed a meta-analysis to assess the association between the VDR gene FokI polymorphism and tuberculosis. Published studies from the PubMed and Embase databases were retrieved. The pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using fixed-or random-effect models. Overall, a significant association was found between FokI polymorphism and tuberculosis risk when all studies were pooled (ff vs FF: OR = 1.36, 95%CI = 1.11-1.66; ff vs Ff: OR = 1.38, 95%CI = 1.14-1.67; dominant model: OR = 0.73, 95%CI = 0.61-0.88). In subgroup analysis by race, a significant association between FokI polymorphism and tuberculosis risk was observed in Asians (ff vs FF: OR = 1.71, 95%CI = 1.02-2.85; ff vs Ff: OR = 1.86, 95%CI = 1.40-2.47; dominant model: OR = 0.55, 95%CI = 0.42-0.72), and no significant association was observed among Caucasians and Africans. In conclusion, the FokI polymorphism in the VDR gene may be related to an increased risk of tuberculosis in Asians. Further large and well-designed studies are needed to confirm these conclusions.

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SLC11A1 and VDR gene variants and susceptibility to tuberculosis and disease progression in East India

Abstract: This study, the first to include evidence on 577G/A and INT4, reports a significant association between SLC11A1 gene variants and PTB with respect to susceptibility and subsequent disease progression in East India.

Cited by 35 publications

References 0 publications

Vitamin D receptor gene FokI, TaqI, BsmI, and ApaI polymorphisms and susceptibility to pulmonary tuberculosis: a meta-analysis

Vitamin D receptor gene FokI, TaqI, BsmI, and ApaI polymorphisms and susceptibility to pulmonary tuberculosis: a meta-analysis

Is There Any Impact of VDR Gene Polymorphism in Bataks Ethnic to Have Tuberculosis?

Vitamin D receptor FokI gene polymorphism and tuberculosis susceptibility: a meta-analysis

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