Vitamin D receptor gene FokI, TaqI, BsmI, and ApaI polymorphisms and susceptibility to pulmonary tuberculosis: a meta-analysis

Abstract

ABSTRACT. The aim of this study was to determine whether vitamin D receptor (VDR) genetic polymorphisms are associated with the susceptibility to pulmonary tuberculosis (PTB). MEDLINE and Embase databases and manual literature searches were used. A meta-analysis was conducted on the associations between the VDR FokI, TaqI, BsmI, and ApaI polymorphisms and PTB susceptibility. A total of 16 studies comprising 3231 patients and 3670 controls met the study inclusion criteria, consisting of 14 studies on the VDR FokI polymorphism, 13 on the VDR TaqI polymorphism, 8 on the VDR BsmI polymorphism, and 5 on the VDR ApaI polymorphism. Meta-analysis of the VDR FokI polymorphism showed no association between PTB and the f allele of the VDR FokI polymorphism (long variant) in all subjects (OR = 1.070, 95%CI = 0.979-1.169, P = 0.134). In contrast, after stratification by ethnicity, meta-analysis indicated that the VDR FokI F allele (short variant) was associated with PTB risk in an East Asian population (OR = 1.507, 95%CI = 1.192-1.906, P = 0.001). Meta-analysis revealed no association between PTB susceptibility and the VDR TaqI t allele in all study subjects (OR = 0.986, 95%CI = 0.839-1.159, P = 0.866) 9119 VDR polymorphisms and tuberculosis ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (3): 9118-9129 (2015) or in individual ethnic populations. Furthermore, a risk of PTB was not associated with the BsmI and ApaI polymorphisms. This metaanalysis suggested that the VDR FokI polymorphism is associated with a susceptibility to PTB in East Asians.

Influence of Apa1 (rs7975232), Taq1 (rs731236) and Bsm1 (rs154410) polymorphisms of vitamin D receptor on preterm birth risk in the Polish population

“…Vitamin D is involved in cell-mediated immunity where it is thought to reduce the production of inflammatory cytokines such as IL-1, IL-6, and TNF-α that are involved in the spontaneous preterm birth [14,15]. Polymorphisms in the VDR gene have been associated with autoimmune and infectious diseases such as tuberculosis, Crohn's disease, asthma or diabetes [16][17][18][19]. Maintenance of a normal pregnancy requires efficient coordination of antimicrobial and anti-inflammatory responses within the feto-placental unit.…”

Nuclear receptor gene polymorphisms and warfarin dose requirements in the Quebec Warfarin Cohort

“…Molecular-based epidemiological studies have identified several functional polymorphisms in the VDR [21] and have demonstrated that the variants can affect the function of the receptor by altering its affinity to vitamin D [28,29]. VDR genetic variants have previously been associated with a number of diseases including pulmonary tuberculosis, diabetes, osteoporosis, asthma, ulcerative colitis, breast and female reproductive cancers, melanoma, systemic lupus erythematous and rheumatoid arthritis, Parkinson's disease, and coronary artery disease [30][31][32][33][34][35][36][37][38][39]. Pharmacogenetic studies have shown that VDR polymorphisms can modulate the response to a number of drugs including anti-tubercular and anti-psoriatic medications, anti-osteoporotic agents in postmenopausal women, interferon and ribavirin in patients with hepatitis C, vitamin D supplementation, and calcitriol [40][41][42][43][44][45][46], as well as with statin-induced myopathy [47].…”

A reappraised meta-analysis of the genetic association between vitamin D receptor BsmI (rs1544410) polymorphism and pulmonary tuberculosis risk

“…Also, all the included studies were of good to modest quality fulfilling the preset needful criteria as tested by NOS quality assessment scale. Although, plenty of meta–analyses have been performed in the past considering various case–control studies analyzing this relationship selected from various databases and concluded accordingly [47–49]. For example, a recent pooled study by Lee and Song [49], based on eight studies reported that Bsm I polymorphism is not associated with risk of PTB.…”