<i>Staphylococcus pasteuri</i>bacteraemia in a patient with leukaemia

Savini, Vincenzo; Catavitello, Chiara; Carlino, Daniela; Bianco, Azaira; Pompilio, Arianna; Balbinot, Andrea; Piccolomini, R; Bonaventura, Giovanni Di; D’Antonio, Domenico

doi:10.1136/jcp.2009.067041

Cited by 16 publications

(16 citation statements)

References 7 publications

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“…Currently, there are 31 species recognized in the genus Staphylococcus and about half of these are indigenous to humans (Kloos and Bannerman, 1994). The role of some species, such as S. epidermidis , S. saprophyticus , S. Pasteuri and S. cohni in human disease has been well documented (Piette and Verschraegen, 2008; Savini et al, 2009). Consistent with previous studies (Aarestrup et al, 2000a; Simeoni et al, 2008), the majority of the erythromycin resistant Staphylococcus spp.…”

Section: Discussionmentioning

confidence: 99%

Effect of subtherapeutic vs. therapeutic administration of macrolides on antimicrobial resistance in Mannheimia haemolytica and enterococci isolated from beef cattle

Zaheer¹,

Cook²,

Klima³

et al. 2013

Front. Microbiol.

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Macrolides are the first-line treatment against bovine respiratory disease (BRD), and are also used to treat infections in humans. The macrolide, tylosin phosphate, is often included in the diet of cattle as a preventative for liver abscesses in many regions of the world outside of Europe. This study investigated the effects of administering macrolides to beef cattle either systemically through a single subcutaneous injection (therapeutic) or continuously in-feed (subtherapeutic), on the prevalence and antimicrobial resistance of Mannheimia haemolytica and Enterococcus spp. isolated from the nasopharynx and faeces, respectively. Nasopharyngeal and faecal samples were collected weekly over 28 days from untreated beef steers and from steers injected once with tilmicosin or tulathromycin or continuously fed tylosin phosphate at dosages recommended by manufacturers. Tilmicosin and tulathromycin were effective in lowering (P < 0.05) the prevalence of M. haemolytica, whereas subtherapeutic tylosin had no effect. M. haemolytica isolated from control- and macrolide-treated animals were susceptible to macrolides as well as to other antibiotics. Major bacteria co-isolated with M. haemolytica from the nasopharynx included Pasteurella multocida, Staphylococcus spp., Acinetobacter spp., Escherichia coli and Bacillus spp. With the exception of M. haemolytica and P. multocida, erythromycin resistance was frequently found in other isolated species. Both methods of macrolide administration increased (P < 0.05) the proportion of erythromycin resistant enterococci within the population, which was comprised almost exclusively of Enterococcus hirae. Injectable macrolides impacted both respiratory and enteric microbes, whereas orally administered macrolides only influenced enteric bacteria.

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Section: Discussionmentioning

confidence: 99%

Effect of subtherapeutic vs. therapeutic administration of macrolides on antimicrobial resistance in Mannheimia haemolytica and enterococci isolated from beef cattle

Zaheer¹,

Cook²,

Klima³

et al. 2013

Front. Microbiol.

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“…The identification results showed that these colonies belonged to S. capitis subsp. ureolyticus (similarity 0.970), strains typically found from skin from head area (Bannerman and Kloos, 1997), and S. pasteuri (0.938), a possible bacteraemia as recently reported (Savini et al, 2009). Table 1 also shows the mean count and the positive detection frequency of the bacteria determined from the air samples, which were taken on the head side of each bed in ICU I. P. aeruginosa represented the most frequently detected (39.1%, n = 46) and abundant (0.65 ± 0.97 cfu/plate, or 11.52 ± 17.16 cfu/m 3 ) species.…”

Section: Airborne and Surface-bound Bacteria Concentrations (Icu I)mentioning

confidence: 99%

Airborne and Surface-Bound Microbial Contamination in Two Intensive Care Units of a Medical Center in Central Taiwan

Huang

Shi

Chen

et al. 2013

Aerosol Air Qual. Res.

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Samples of airborne and surface-bound microbial contamination were taken in two intensive care units of a large-scale medical center. Microbial analyses included total bacterial and fungal loads, as well as the four bacterial species of Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Acinetobacter baumannii. Among the 114 surface samples taken from seven designated surface locations of room and equipment for each patient, P. aeruginosa was the most frequently detected (19.3%) and most abundant (mean count: 4.18 cfu/plate) bacterium, whereas the respirator represented the most heavily contaminated surface location in both total pathogenic bacteria colony counts (272 cfu) and frequency of positive detection (38.2%). P. aeruginosa also represented the most frequently detected (39.1%, n = 46) and abundant (11.52 ± 17.16 cfu/m 3 ) bacterium in the air samples (n = 46), and was the only bacterium exhibiting a positive correlation of the mean counts between air and surface samples. The data analysis results further suggested a higher value of relative risk among the infected patients in the presence of the pathogens as compared to those in the absence of them, although the evidence of a of correlation for the individual bacterial species between the environmental samples and infected patients was inconclusive. This study also found that the mean airborne counts and the detection frequencies of these bacteria after patient visitation periods were higher than those before visitation, and that the installation of local air ionizers did not lead to any discernible differences in total bacterial and fungal concentrations.

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“…All isolates were identified as S. pasteuri except SPv17 which was found to be Bacillus licheniformis, one of the most important bacteria in industrial enzyme production of serine protease and is commonly found in the soil and on ground dwelling bird feathers and some aquatic species (23). S. pasteuri is a coagulase-negative, Gram positive organism which is emerging as an agent of nosocomial infections and a blood derivatives contaminant.…”

Section: Discussionmentioning

confidence: 99%

“…All Spv isolates used in this study showed resistance to gentamicin, as evidenced by the zone of inhibition, except isolate # H18 which was identified as B. licheniformis. Interestingly, gentamicin is an aminoglycosides which has been reported in clinical isolates of Staphylococcus aureus (21) and in S pasteuri (22) suggesting that Spvs found at the CE plaque may also be clinically relevant. At least 3 isolates were completely resistant to tetracycline and 1 isolate was resistant to streptomycin while susceptibility to ampicillin, penicillin G, streptomycin and tetracycline was observed at varying range ( Fig 6B).…”

Section: Antibiotic Resistance (Ar) Is Prevalent In All Spvsmentioning

confidence: 99%

Staphylococcus pasteuri isolates (Spvs) from human atherosclerotic plaques mediate virulence, intracellular resistance and transendothelial invasion of macrophages: A mechanistic paradigm for microbial pathogenicity in atherosclerosis

Haque

Modi

Haque

et al. 2019

Preprint

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Atherosclerotic cardiovascular disease, a chronic inflammatory condition of multifactorial etiology, is the leading cause of death worldwide. The concept of 'bacterial persistence' has been proposed as one of several contributing factors to this disease. We hypothesized that the infectious agent(s) found at the site of the atheroma may be dormant but perpetuate virulence in response to host defense and other physiological triggers. In this study, we sought to identify the source of persistent infection in human atherosclerotic plaque and define how pathogen virulence and host defenses mediate plaque vulnerability. Whole genome sequencing (WGS) was used to identify bacteria from pure cultures obtained from atherosclerotic tissues of living subjects diagnosed with more than 70% occlusion of the carotid artery undergoing carotid endarterectomy (CE). WGS identified the predominant species as S. pasteuri (Spv) in all CE isolates grown in pure culture except one isolate which was identified as B. licheniformis. All S. pasteuri isolates (Spvs) were found to contain genes for widespread virulence, invasion, and intracellular resistance. As macrophages (Mφs) play a decisive role at all stages of this disease we treated mouse Mφs (RAW 264.7) with Spvs. While all Spvs tested demonstrated their ability to survive phagocytosis, the highly virulent Spvs also activated Mφs and induced trans-endothelial cell migration of these cells which was mediated via the CC chemokine CCL1 and its receptor CCR8. In conclusion, we show that Spvs are found in CE plaques, have the capacity to survive phagocytosis and induce the transmigration of Mφs across an endothelial barrier in a CCL1-CCR8 dependent process. These findings highlight the significance of carotid vessels as a reservoir for S. pasteuri, a pathogen found in products used routinely in human consumption; this may explain how microbial pathogenicity modulates plaque vulnerability in atherosclerosis.

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Staphylococcus pasteuribacteraemia in a patient with leukaemia

Cited by 16 publications

References 7 publications

Effect of subtherapeutic vs. therapeutic administration of macrolides on antimicrobial resistance in Mannheimia haemolytica and enterococci isolated from beef cattle

Effect of subtherapeutic vs. therapeutic administration of macrolides on antimicrobial resistance in Mannheimia haemolytica and enterococci isolated from beef cattle

Airborne and Surface-Bound Microbial Contamination in Two Intensive Care Units of a Medical Center in Central Taiwan

Staphylococcus pasteuri isolates (Spvs) from human atherosclerotic plaques mediate virulence, intracellular resistance and transendothelial invasion of macrophages: A mechanistic paradigm for microbial pathogenicity in atherosclerosis

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