<i>Streptococcus cristatus</i> attenuates <i>Fusobacterium nucleatum</i>‐induced interleukin‐8 expression in oral epithelial cells

Zhang, G.; Chen, R.; Rudney, Joel D.

doi:10.1111/j.1600-0765.2007.01057.x

Cited by 40 publications

(50 citation statements)

References 30 publications

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“…F. nucleatum can also associate with Streptococcus cristatus , and transports noninvasive S. cristatus into oral epithelial cells (Edwards et al , 2006). Conversely, S. cristatus attenuates F. nucleatum –induced cytokine expression in oral epithelial cells (Zhang et al , 2008). The relationship between the two bacterial species can be antagonistic or synergistic, depending perhaps on the composition of the remaining species in the biofilm or other environmental conditions.…”

Section: Characterizing Interactions Between Oral Microorganismsmentioning

confidence: 99%

The Oral Microbiota: Living with a Permanent Guest

Avila

Ojcius

Yılmaz

2009

DNA and Cell Biology

379

317

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The oral cavity of healthy individuals contains hundreds of different bacterial, viral, and fungal species. Many of these can associate to form biofilms, which are resistant to mechanical stress or antibiotic treatment. Most are also commensal species, but they can become pathogenic in responses to changes in the environment or other triggers in the oral cavity, including the quality of an individual’s personal hygiene. The complexity of the oral microbiome is being characterized through the newly developed tools of metagenomics. How the microbiome of the oral cavity contributes to health and disease is attracting the interest of a growing number of cell biologists, microbiologists, and immunologists.

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Section: Characterizing Interactions Between Oral Microorganismsmentioning

confidence: 99%

The Oral Microbiota: Living with a Permanent Guest

Avila

Ojcius

Yılmaz

2009

DNA and Cell Biology

379

317

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“…Intriguingly, these include an uncommon Campylobacter species, C.showae , a CRC- associated isolate of which was demonstrated to aggregate with F.nucleatum in vitro , and to have a genome sequence containing genes homologous to known virulence determinants, including components of the vir operon of Helicobacter pylori [90]. Since it is known that F.nucleatum can specifically associate with, and promote invasion of, other microbes, as has clearly been demonstrated for Streptococcus cristatus [91], and that such associations can modify the host response to infection [92,93], it is imperative to broaden our view of infection in CRC to consider more than one microbe at a time. The influence of the surrounding gut microbiota on E.coli pathogenesis, as for F.nulceatum , is likely important in CRC pathogenesis.…”

Section: Conclusion/perspectivementioning

confidence: 99%

Fusobacterium and Enterobacteriaceae: Important players for CRC?

2014

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The gut microbiota plays an essential role in regulating intestinal homeostasis through its capacity to modulate various biological activities ranging from barrier, immunity and metabolic function. Not surprisingly, microbial dysbiosis is associated with numerous intestinal disorders including inflammatory bowel diseases (IBD) and colorectal cancer (CRC). In this piece, we will review recent evidence that gut microbial dysbiosis can influence intestinal disease, including colitis and CRC. We will discuss the biological events implicated in the development of microbial dysbiosis and the emergence of CRC-associated microorganisms, focusing on E.coli and F. nucleatum. Finally, the mechanisms by which E.coli and F. nucleatum exert potentially carcinogenic effects on the host will be reviewed.

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“…In contrast, S. gordonii was found to inhibit the release of IL-6 and IL-8 from epithelial cells (222), a phenomenon that may contribute to the ability of this organism to persist in the oral cavity as a commensal. Interestingly, S. gordonii and other oral streptococci were also shown to suppress the IL-8 release normally induced by the opportunistic periodontopathogen Fusobacterium nucleatum (664), providing insight into how the presence of such commensals might promote a "healthy" oral environment (273). Aside from proinflammatory effects, cytokine release may also influence mechanisms such as streptococcal invasion, as described above.…”

Section: Host Cell Modulationmentioning

confidence: 99%

StreptococcusAdherence and Colonization

Nobbs

Lamont

Jenkinson

2009

Microbiol Mol Biol Rev

552

569

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SUMMARY Streptococci readily colonize mucosal tissues in the nasopharynx; the respiratory, gastrointestinal, and genitourinary tracts; and the skin. Each ecological niche presents a series of challenges to successful colonization with which streptococci have to contend. Some species exist in equilibrium with their host, neither stimulating nor submitting to immune defenses mounted against them. Most are either opportunistic or true pathogens responsible for diseases such as pharyngitis, tooth decay, necrotizing fasciitis, infective endocarditis, and meningitis. Part of the success of streptococci as colonizers is attributable to the spectrum of proteins expressed on their surfaces. Adhesins enable interactions with salivary, serum, and extracellular matrix components; host cells; and other microbes. This is the essential first step to colonization, the development of complex communities, and possible invasion of host tissues. The majority of streptococcal adhesins are anchored to the cell wall via a C-terminal LPxTz motif. Other proteins may be surface anchored through N-terminal lipid modifications, while the mechanism of cell wall associations for others remains unclear. Collectively, these surface-bound proteins provide Streptococcus species with a “coat of many colors,” enabling multiple intimate contacts and interplays between the bacterial cell and the host. In vitro and in vivo studies have demonstrated direct roles for many streptococcal adhesins as colonization or virulence factors, making them attractive targets for therapeutic and preventive strategies against streptococcal infections. There is, therefore, much focus on applying increasingly advanced molecular techniques to determine the precise structures and functions of these proteins, and their regulatory pathways, so that more targeted approaches can be developed.

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Streptococcus cristatus attenuates Fusobacterium nucleatum‐induced interleukin‐8 expression in oral epithelial cells

Abstract: Our data suggest that S. cristatus may exert immunomodulatory effects on the interleukin-8 response of oral epithelial cells to F. nucleatum challenge.

Cited by 40 publications

References 30 publications

The Oral Microbiota: Living with a Permanent Guest

The Oral Microbiota: Living with a Permanent Guest

Fusobacterium and Enterobacteriaceae: Important players for CRC?

StreptococcusAdherence and Colonization

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