<i>Strongylocentrotus</i><i>nudos</i> Egg Polysaccharide induces autophagy and apoptosis in leukaemia cells by regulating mitochondrial function

Wang, Chong; Li, Mengya; Shen, Xiaohui; Liu, Yanfang; Wang, Shujuan

doi:10.1111/jcmm.15995

Cited by 6 publications

(4 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Strongylocentrotus nudus is another kind of precious traditional Chinese medicine, which has the remarkable effect of anti-tumor ( 95 ). As a D-glucan containing an α-1, 4-linked backbone, and α-1, 3-linked branches, Strongylocentrotus nudus Egg Polysaccharide is extracted and purified from sea urchins’ eggs ( 96 ).…”

Section: Experimental and Clinical Trials On Hcc Of Tcm Polysaccharid...mentioning

confidence: 99%

See 1 more Smart Citation

Antitumor immunostimulatory activity of the traditional Chinese medicine polysaccharide on hepatocellular carcinoma

Liu,

Wu,

Hao

2024

Front. Immunol.

View full text Add to dashboard Cite

Hepatocellular carcinoma (HCC) is a prevalent malignancy, often associated with compromised immune function in affected patients. This can be attributed to the secretion of specific factors by liver cancer cells, which hinder the immune response and lead to a state of immune suppression. Polysaccharides derived from traditional Chinese medicine (TCM) are valuable constituents known for their immunomodulatory properties. This review aims to look into the immunomodulatory effects of TCM polysaccharides on HCC. The immunomodulatory effects of TCM polysaccharides are primarily manifested through the activation of effector T lymphocytes, dendritic cells, NK cells, and macrophages against hepatocellular carcinoma (HCC) both in vivo and in vitro settings. Furthermore, TCM polysaccharides have demonstrated remarkable adjuvant antitumor immunomodulatory effects on HCC in clinical settings. Therefore, the utilization of TCM polysaccharides holds promising potential for the development of novel therapeutic agents or adjuvants with advantageous immunomodulatory properties for HCC.

show abstract

Section: Experimental and Clinical Trials On Hcc Of Tcm Polysaccharid...mentioning

confidence: 99%

“…Strongylocentrotus nudus is another kind of precious traditional Chinese medicine, which has the remarkable effect of anti-tumor (95).…”

Section: Strongylocentrotus Nudus Eggs Polysaccharidementioning

confidence: 99%

Antitumor immunostimulatory activity of the traditional Chinese medicine polysaccharide on hepatocellular carcinoma

Liu,

Wu,

Hao

2024

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…Under the circumstance that cells are stimulated, the structure of mitochondria could undergo a certain degree of shift to the pathological mode due to the highest sensitivity to the injuries among all subcelluar organelles [101]. Wang et al found that the abnormal structure of mitochondria in intestinal epithelial cells of mice with ulcerative colitis can be proportionally restored with the treatment of high dose of mycelium polysaccharide and the membrane were prone to be intact and less swollen [102].…”

Section: Morphological Alterationmentioning

confidence: 99%

An overview of biological functions of natural polysaccharides: influence factors, mitochondria and signaling pathways

Guo

et al. 2023

Preprint

View full text Add to dashboard Cite

Natural polysaccharide is a type of functional carbohydrate polymer under heated investigation. The structure of natural polysaccharides is in close relationship with their actual biological functions such as antioxidant, immunoregulation and antitumor effects. Herein, we have identified numerous factors that significantly affect the biological functions of polysaccharides, including molecular weight, degree of polymerization, hydrophilicity and metabolic capability. Mitochondria, as a key polysaccharide-targeting organelle, undergo a number of alterations during the treatment, which includes morphological changes, ROS production, membrane potential and permeability, ETC activity and ATP production. Intriguingly, polysaccharides exhibit protective effects and maintain mitochondrial function on normal cells, while in cancer cells, polysaccharides tend to accelerate apoptosis and exacerbate mitochondrial dysfunction. Numerous signaling pathways, including antioxidant signaling pathway, anti-inflammatory signaling pathway and apoptotic signaling pathway are activated correspondingly. This review underlines the significance of the structural features of the polysaccharide, and thereafter indicates the modes of physiological function.

show abstract

“…Polysaccharides are natural biological macromolecules derived from fungi, marine organisms, plants, lichens, and animals (Ooi and Liu, 2000). Previous studies have shown that polysaccharides and polysaccharide-protein complexes exhibit significant anticancer activities and increase the efficacy of other small-molecule chemotherapy drugs (Zong et al, 2012;Zhang et al, 2017;Xie et al, 2019;Wang et al, 2020). Polysaccharides are superior in inhibiting tumor metastasis.…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetic study of Strongylocentrotus nudus egg polysaccharide in rats and beagles using a 3H-labeling method

Xing

Zhu²,

Liao³

et al. 2023

Front. Pharmacol.

View full text Add to dashboard Cite

Strongylocentrotus nudus egg polysaccharide (SEP) extracted from sea urchins has potential anticancer activity. However, little is known about its pharmacokinetic properties. To investigate the pharmacokinetics of SEP, it was radiolabeled with tritium. Furthermore, a sensitive, selective, and rapid liquid scintillation counter (LSC) method for quantifying 3H-SEP in biological matrix was validated. The lower quantification limit of the method was 4 Bq. The relative standard deviations (RSDs) of the intra- and inter-day precision were <3.0% and <3.9%, respectively. 3H-SEP was successfully applied to investigate the pharmacokinetics of SEP after intravenous administration of 20, 40, and 80 mg/kg (40 μCi/kg) in rats and 5, 10, and 20 mg/kg (6 μCi/kg) in beagles. The AUC(0-t) of SEP at three different doses was 487.81 ± 39.99 mg/L*h, 1,003.10 ± 95.94 mg/L*h, and 2,188.84 ± 137.73 mg/L*h in rats and 144.12 ± 3.78 mg/L*h, 322.62 ± 28.03 mg/L*h, and 754.17 ± 37.79 mg/L*h in beagles. The terminal elimination half-life (t1/2) of SEP was longer in beagles (204.29 ± 139.34 h) than in rats (35.48 ± 6.04 h). The concentration of SEP in plasma declined rapidly in both rats and beagles. All the study results provide detailed pharmacokinetic profiles of SEP in two kinds of animals, which will be helpful for further development.

show abstract

Strongylocentrotusnudos Egg Polysaccharide induces autophagy and apoptosis in leukaemia cells by regulating mitochondrial function

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 6 publications

References 43 publications

Antitumor immunostimulatory activity of the traditional Chinese medicine polysaccharide on hepatocellular carcinoma

Antitumor immunostimulatory activity of the traditional Chinese medicine polysaccharide on hepatocellular carcinoma

An overview of biological functions of natural polysaccharides: influence factors, mitochondria and signaling pathways

Pharmacokinetic study of Strongylocentrotus nudus egg polysaccharide in rats and beagles using a 3H-labeling method

Contact Info

Product

Resources

About