Strongyloides‐specific IgA, IgG and IgG immune complex profile in patients with pulmonary tuberculosis

Abstract

Aims To describe an anti‐Strongyloides IgA, IgG and IgG immune complex antibody response profile in patients with pulmonary tuberculosis. Methods and Results Saliva and serum samples were collected from 100 individuals: group I, 50 apparently healthy individuals; and group II, 50 pulmonary tuberculosis patients. The IgA, IgG and IgG immune complex detection were carried out via an ELISA immunoenzymatic test. Optical density medians in saliva samples of IgA antibody (median of 7.21) and IgG‐IC (median of 4.95) were significantly higher in tuberculosis group compared to control individuals (median IgA of 3.93 and IgG‐IC of 2.38). Conclusion This study presents antibody data to the field of pulmonary tuberculosis and strongyloidiasis coinfection, including saliva samples, and especially IgG immune complex detection.

Immune complexes as a tool for strongyloidiasis immunodiagnosis in kidney and liver transplant candidate

“…[8][9][10] In addition to the use of conventional serological methods for immunological diagnosis of strongyloidiasis, recent years have seen a gradual increase in the number of studies using immune complexes (IC) as alternative diagnoses for S. stercoralis infections. [10][11][12] Infectious diseases result not only in the production of antibodies but also in the formation of antigen-antibody complexes. These IC are important because they bind to phagocytic cells, where they are destroyed and eliminated, and can be used as biomarkers of the disease.…”