<i>Swertia</i> (Gentianaceae): Chemical and Pharmacological Aspects

Brahmachari, Goutam; Mondal, Sudip; Gangopadhyay, Arindam; Gorai, Dilip; Mukhopadhyay, B.; Saha, Shamal; Brahmachari, A. K.

doi:10.1002/cbdv.200490123

Cited by 108 publications

(62 citation statements)

References 84 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…But metabolites such as flavonoids, iridoid glycosides and terpenoids are also other active constituents. 8 In the present paper, we report a comparative study of antioxidant, acetylcholinesterase, α-amylase and α-glucosidase inhibitory properties of leafy shoots of three Indian species of Swertia e.g. S. bimaculata, S. chirata and S. decussata.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant, anti-acetylcholinesterase and anti-glycosidase properties of three species of Swertia, their xanthones and amarogentin: A comparative study

Nag

Das²,

Das³

et al. 2015

Phcog J

View full text Add to dashboard Cite

Aim:The aim of the study was to analyze the antioxidant, anti-amylase, anti-glucosidase and antiacetylcholinesterase (anti-AChE) properties of the leafy shoots of three Indian species of Swertia e.g. Swertia chirata and its substitutes Swertia bimaculata, and Swertia decussata, their xanthones and amarogentin. Methods: Antioxidant activity of the methanolic extracts of leafy shoots was measured in terms of DPPH, superoxide and nitric oxide radical scavenging activities as well as metal chelating properties. Enzyme inhibitory properties were measured using AChE, α-amylase and α-glucosidase respectively. Five xanthones bellidifolin (1), swerchirin (2), decussatin (3), mangiferin (4) and 1-hydroxy-3,5,8-trimethoxy xanthone (6) and one iridoid, amarogentin (5) were isolated from Swertia chirata. The activities of the isolated components were compared. Results: Swertia chirata exhibited best antioxidant and antiAChE properties than the other two species. The plants also possessed α-glucosidase inhibitory properties but weak α-amylase inhibitory activity. Highest activities were observed in Swertia chirata. We report here, for the first time, the antioxidant, anti-AChE and anti-glycosidase activity of 1-hydroxy-3,5,8-trimethoxy xanthone. This xanthone had strongest DPPH radical scavenging activity and anti-AChE property. Conclusion: The results suggest the beneficial effects of the xanthones of Swertia chirata. But further study should be carried out to prove the efficacy in vivo.

show abstract

Section: Introductionmentioning

confidence: 99%

Antioxidant, anti-acetylcholinesterase and anti-glycosidase properties of three species of Swertia, their xanthones and amarogentin: A comparative study

Nag

Das²,

Das³

et al. 2015

Phcog J

View full text Add to dashboard Cite

show abstract

“…S. mussotii are collected and used mostly for their medicinal effects. Its major active compounds have been shown to be swertiamarin, mangiferin and gentiopicroside, which possess unique medicinal properties against rheumatism, osteoarthritis, hepatitis, gastritis and cholecystitis [2]. A medicine has been produced from this plant and sold as capsules for the treatment of these diseases [1].…”

Section: Introductionmentioning

confidence: 99%

An Efficient Method for Plant Regeneration from Calli of <i>Swertia mussotii</i>, an Endangered Medicinal Herb

He¹,

Xu²,

Yang³

et al. 2012

AJPS

View full text Add to dashboard Cite

Swertia mussotii Franch is an endangered medicinal plant in the Qinghai-Tibet Plateau. Its regeneration from callus culture is very difficult. In this study, an efficient method for plant regeneration was developed from its calli. The calli derived from young stem explants of S. mussotii were cultured at two types of temperature treatments to test their efficiency of shoot regeneration. When the calli were cultured at variable temperature (VT, 20˚C during the day and 10˚C at night) treatment, the adventitious shoots were formed at each combination tested. However, that did not occur when the calli were cultured at constant temperature (CT, 25˚C) treatment. The best response (53.7%) of plantlet regeneration was obtained on Murashige and Skoog (MS) medium containing 3 mg·l −1 6-benzylaminopurine with 0.5 mg·l −1 α-naphthaleneacetic acid in the VT treatment. The regenerated plantlets were rooted on half-strength MS medium without growth regulators. They flowered in the following subculture. The results indicate that the treatment of day-night temperature difference is a critical factor to callus differentiation in S. mussotii. This protocol can be used for conservation as well as mass propagation of this medicinal plant.

show abstract

“…The genus Swertia (family Gentianaceae), founded by Linnaeus in 1753 in honor of Emanuele Sweert, an eminent Dutch gardener, comprises about 170 known species that are mainly native to temperate regions of the northern hemisphere (Brahmachari et al, 2004). About 40 species of Swertia are found in India, mainly at high altitude (1200-3000 m) in the temperate Himalayan region ranging from Kashmir to Bhutan, and also in the Khasia and Western Ghats hills (Chopra et al, 1956;Anonymous, 1982;Scartezzini and Speroni, 2000).…”

Section: Introductionmentioning

confidence: 99%

“…Although plants belonging to various Swertia species have been described in different traditional medicine systems for use as crude drugs for the treatment of various ailments, Swertia chirayita occupies the most prominent position as regards its medicinal and therapeutic capabilities. It is traditionally used as a bitter tonic in stimulating appetite, as a febrifuge and for treating asthma and liver disorders (Brahmachari et al, 2004). Its medicinal potential is vividly described in various traditional medicine systems such as Ayurveda and Unani and in the American and British pharmacopoeias.…”

Section: Introductionmentioning

confidence: 99%

AFLP markers for identification of Swertia species (Gentianaceae)

Misra¹,

Shasany²,

Shukla³

et al. 2010

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. The genus Swertia is well known for its medicinal properties, as described in the Indian pharmacopoeia. Different members of this genus, although somewhat similar in morphology, differ widely in their pharmacological and therapeutic properties. The most important species of this genus, with maximal therapeutic properties, is S. chirayita, which is often adulterated with other lesspotent Swertia spp. There is an existing demand in the herbal drug industry for an authentication system for Swertia spp, in order to enable their commercial use as genuine phytoceuticals. To this end, we used amplified fragment length polymorphism (AFLP) to produce DNA fingerprints for six Swertia species. Nineteen accessions (2 of S. chirayita, 3 of S. angustifolia, 2 of S. bimaculata, 5 of S. ciliata, 5 of S. cordata, and 2 of S. alata) were used in the study, which employed 64 AFLP selective primer pairs. Only 46 selective primer pairs were found to be useful for all the accessions. A total of 5312 fragments were produced by these 46 primer pairs. Species-specific markers were identified for all six Swertia species (131 for S. chirayita, 19 for S. angustifolia, 181 for S. bimaculata, 47 for S. ciliata, 94 for S. cordata, and 272 for S. alata). These AFLP fingerprints of the Swertia species could be used to authenticate drugs made with Swertia spp and to resolve adulteration-related problems faced by the commercial users of these herbs.

show abstract

Swertia (Gentianaceae): Chemical and Pharmacological Aspects

Cited by 108 publications

References 84 publications

Antioxidant, anti-acetylcholinesterase and anti-glycosidase properties of three species of Swertia, their xanthones and amarogentin: A comparative study

Antioxidant, anti-acetylcholinesterase and anti-glycosidase properties of three species of Swertia, their xanthones and amarogentin: A comparative study

An Efficient Method for Plant Regeneration from Calli of <i>Swertia mussotii</i>, an Endangered Medicinal Herb

AFLP markers for identification of Swertia species (Gentianaceae)

Contact Info

Product

Resources

About

Swertia (Gentianaceae): Chemical and Pharmacological Aspects

Cited by 108 publications

References 84 publications

Antioxidant, anti-acetylcholinesterase and anti-glycosidase properties of three species of Swertia, their xanthones and amarogentin: A comparative study

Antioxidant, anti-acetylcholinesterase and anti-glycosidase properties of three species of Swertia, their xanthones and amarogentin: A comparative study

An Efficient Method for Plant Regeneration from Calli of &lt;i&gt;Swertia mussotii&lt;/i&gt;, an Endangered Medicinal Herb

AFLP markers for identification of Swertia species (Gentianaceae)

Contact Info

Product

Resources

About

An Efficient Method for Plant Regeneration from Calli of <i>Swertia mussotii</i>, an Endangered Medicinal Herb