t-3-Methyl-1-nitroso-r-2,c-6-diphenylpiperidin-4-one oxime monohydrate

Abstract

In the title compound, C18H19N3O2·H2O, the piperidine ring adopts a distorted boat conformation. In the solid state, the mol­ecules are linked by inter­molecular O—H⋯O and O—H⋯N hydrogen bonds involving water mol­ecules.

(8R,9S,13S,14S)-17-Butyl-3-methoxy-17-aza-D-homoestra-1,3,5(10)-triene-16,17a-dione

“…1. The bond lengths and bond angles in (I) are comparable with those in the structures of (II) and the related 17-butyl-and 17-allyl-16,17a-dioxo-17-aza-D-homoestra-1,3,5(10)-trien-3-yl acetate derivatives, (III) and (IV), respectively (Hema et al, 2004(Hema et al, , 2005a. In (I), the cyclohexene ring, B, adjacent to the aromatic ring adopts a 7,8-half-chair conformation [puckering parameters (Cremer & Pople, 1975) Q = 0.4825 (18) Å , = 44.6 (2) , ' = 145.5 (3) ] as a result of the fusion with the planar aromatic ring A.…”

“…deviation of the butyl group atoms N17, C19, C20, C21 and C22 from their mean plane is 0.044 Å , and the dihedral angle between the plane of the butyl group and the least-squares plane through ring D is 82.52 (10) . The corresponding values observed in (II), (III) and (IV) are 89.91 (16), 82.1 (2) and 84.5 (5) , respectively (Hema et al, 2004(Hema et al, , 2005a. Ring D in (I) adopts a flattened 14-sofa conformation [Q = 0.5189 (18) Å , = 61.1 (2) , ' = 199.8 (2) ] and the flattening of the ring is indicated by the torsion angles C13-C17a-N17-C16 [À1.1 (2) ] and C17a-N17-C16-C15 [14.4 (2) ].…”

“…The activities of certain estrogenic and androgenic steroids are significantly altered by methylation of the C3 hydroxy group (Duax et al, 1979). As a continuation of our previous studies on D-homoestra-1,3,5(10)-triene derivatives (Hema et al, 2004(Hema et al, , 2005a, the X-ray crystal structure determination of the title compound, (I), has been undertaken in order to better understand the influence of structural modifications upon overall molecular geometry and conformation. Compound (I) possesses a bulky substituent at the N atom of the heterocyclic ring, and has a methoxy substituent at C3 of the aromatic ring.…”

“…Compound (I) possesses a bulky substituent at the N atom of the heterocyclic ring, and has a methoxy substituent at C3 of the aromatic ring. The structure of the analogous 17-butyl-16,17a-dioxo-17-aza-D-homoestra-1,3,5(10)-trien-3ol, (II), was presented in the preceding paper (Hema et al, 2005b).…”

Conformational Studies of Some N-Acyl-3- Ethylpiperidin-4-Ones

“…The conformational studies of various 2,6-dimethyl, 2.6-diethyl and 2,6-diphenylpiperidone derivatives [1][2][3][4][5][6][7][8][9] exhibited normal chair conformation. The same type of compounds i.e., 3-isopropylpiperidin-4-one derivatives are prepared and also done conformational studies (Manimekali et al 10) .…”