<i>Tanreqing</i>Injection Combined with Conventional Western Medicine for Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Systematic Review

Zhong, Yunqing; Mao, Bing; Wang, Gang; Fan, Tao; Liu, Xuemei; Diao, Xiang; Fu, Juan

doi:10.1089/acm.2009.0686

Cited by 30 publications

(25 citation statements)

References 9 publications

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“…Findings from this review are comparable with previous systematic reviews that evaluated Chinese herbal medicine combined with RP for AECOPD [5, 34]. These reviews also evaluated lung function, arterial blood gases, and clinical effective rate and the study participants were diagnosed with the Chinese medicine syndrome, phlegm-heat obstructing the Lung.…”

Section: Discussionsupporting

confidence: 77%

“…One review used Tan re qing injection and included 14 trials involving 954 participants. Tan re qing injection combined with pharmacotherapy improved lung function, clinical efficacy, and arterial blood gas and shortened the length of hospital stay compared with pharmacotherapy [5]. In the other review 16 studies used Da cheng qi decoction combined with pharmacotherapy and all outcomes were improved (lung function, clinical efficacy, and arterial blood gas) [34].…”

Section: Discussionmentioning

confidence: 99%

“…Chinese herbal medicine (CHM) showed potential beneficial effect for AECOPD in a recent systematic review; lung function, arterial blood gases, and clinical effective rate were improved by a Chinese herbal formula Tan re qing [5]. Despite Tan re qing's positive effects this formula is not commonly used outside of China and is given intravenously, which is not the traditional delivery method of CHM.…”

Section: Introductionmentioning

confidence: 99%

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Chinese Herbal Medicine (Weijing Decoction) Combined with Pharmacotherapy for the Treatment of Acute Exacerbations of Chronic Obstructive Pulmonary Disease

Liu

Shergis

Chen

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Objective. To evaluate the efficacy and safety of Weijing decoction combined with routine pharmacotherapy (RP) for the treatment of acute exacerbations of chronic obstructive pulmonary disease (AECOPD). Methods. Randomized controlled trials (RCT) evaluating Weijing decoction for AECOPD were included. English, Chinese, and Japanese databases were searched from their respective inceptions to June 2013. The methodological quality was assessed according to the Cochrane Collaboration's risk of bias tool. All data were analyzed and synthesized using RevMan 5.2 software. Results. Fifteen (15) studies involving 986 participants were included. Participants were diagnosed with COPD in the acute exacerbation stage. In addition, most of studies reported that they included participants with the Chinese medicine syndrome, phlegm-heat obstructing the Lung. Weijing decoction combined with RP improved lung function (forced expiratory volume in one second; FEV1), arterial blood gases (PaO2 and PaCO2), clinical effective rate, and reduced inflammatory biomarkers (TNF-α and IL-8) when compared with RP alone. No severe adverse events were reported in these studies. Conclusions. Weijing decoction appeared to be beneficial for AECOPD and well-tolerated when taken concurrently with RP, such as antibiotics, bronchodilators (oral and inhaled), and mucolytics.

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Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Chinese Herbal Medicine (Weijing Decoction) Combined with Pharmacotherapy for the Treatment of Acute Exacerbations of Chronic Obstructive Pulmonary Disease

Liu

Shergis

Chen

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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“…It is often complicated with exacerbations and hospitalizations [2], which increased mortality and reduced life-expectancy [3]. At present, western medicine treatment of COPD, especially treatment of the stable stage, mainly focuses on symptomatic treatment [4], and drug treatment mostly focuses on improving symptoms and (or) reducing complications [5]. Using Chinese medicines or integrated Chinese and Western medicines to treat stable COPD has significant efficacy [6], improving pulmonary function and increasing diaphragm muscular tension [7].…”

Section: Introductionmentioning

confidence: 99%

Effect of Radix Stemonae concentrated decoction on the lung tissue pathology and inflammatory mediators in COPD rats

Wang

Yang

et al. 2016

BMC Complement Altern Med

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BackgroundChronic obstructive pulmonary disease (COPD) is a common and frequently occurring respiratory disease. At present, western medicine treatment of COPD mainly focuses on symptomatic treatment. Using Chinese medicines or integrated Chinese and Western medicines to treat stable COPD has significant efficacy. In this study, we aimed to observe the effect of Radix Stemonae concentrated decoction on the lung tissue pathology and inflammatory mediators in COPD rats and explore its possible mechanism.MethodsSD rats were randomized into blank group, COPD model group and Radix Stemonae group, 10 cases in each group. Rats were fed for 112 days. Before the rats were sacrificed, lung function of the animals was tested. The right lower lung was fixed for morphologic observation. The inflammatory mediators in serum were determined using enzyme-linked immuno sorbent assay.ResultsBody weight of animals in the model group was significantly decreased compared with blank group (P < 0.05). After gavage therapy with Radix Stemonae, body weight was significantly increased (P < 0.05). Compared with the blank group, pulmonary functions of rats in the model group were significantly abnormal (P < 0.05), while in Radix Stemonae group, these indicators turned much better than model group (P < 0.05). As for pathological changes in lungs, airway inflammation in the model group was aggravated. In the Radix Stemonae group, inflammation and emphysema were much milder. The concentrations of TNF-α, IL-8 and LTB4 in both model group and Radix Stemonae group were increased significantly (P < 0.05). But the levels in Radix Stemonae group were decreased significantly than model group (P < 0.05).ConclusionRadix Stemonae concentrated decoction may mitigate and improve airway rebuilding in the lungs of COPD rats by inhibiting the release of inflammatory mediators.

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“…Recently, several systematic reviews have been conducted, indicating the potential effectiveness of Chinese herbal medicine in COPD [18–25]. However, the efficacy remains inconclusive due to low quality of studies.…”

Section: Introductionmentioning

confidence: 99%

A Systematic Review and Meta‐Analysis of Herbal Medicine on Chronic Obstructive Pulmonary Diseases

Chen

Ke-jian

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Herbal medicine (HM) as an adjunct therapy has been shown to be promising for the chronic obstructive pulmonary disease (COPD). However, the role of herbs in COPD remains largely unexplored. In this present study, we conducted the systematic review to evaluate the efficacy of herbs in COPD. 176 clinical studies with reporting pulmonary function were retrieved from English and Chinese database. Commonly used herbs for acute exacerbations stage (AECOPD) and stable COPD stage (SCOPD) were identified. A meta-analysis conducted from 15 high quality studies (18 publications) showed that HM as an adjunct therapy had no significant improvement in pulmonary function (FEV1, FEV%, FVC, and FEV1/FVC) compared to conventional medicine. The efficacy of the adjunct HM on improving the arterial blood gas (PaCO2 and PaO2) for AECOPD and SCOPD remains inconclusive due to the heterogeneity among the studies. However, HM as an adjunct therapy improved clinical symptoms and quality of life (total score, activity score, and impact score of St. George's Respiratory Questionnaire). Studies with large-scale and double-blind randomized controlled trials are required to confirm the role of the adjunct HM in the management of COPD.

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TanreqingInjection Combined with Conventional Western Medicine for Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Systematic Review

Abstract: Within the limitations of this systematic review, we can conclude that compared with therapy B, therapy A may provide more benefits for patients with acute exacerbations of COPD. Further large-scale high-quality trials are warranted.

Cited by 30 publications

References 9 publications

Chinese Herbal Medicine (Weijing Decoction) Combined with Pharmacotherapy for the Treatment of Acute Exacerbations of Chronic Obstructive Pulmonary Disease

Chinese Herbal Medicine (Weijing Decoction) Combined with Pharmacotherapy for the Treatment of Acute Exacerbations of Chronic Obstructive Pulmonary Disease

Effect of Radix Stemonae concentrated decoction on the lung tissue pathology and inflammatory mediators in COPD rats

A Systematic Review and Meta‐Analysis of Herbal Medicine on Chronic Obstructive Pulmonary Diseases

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