2003
DOI: 10.1046/j.1365-2990.2003.00435.x
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Tau phosphorylation and kinase activation in familial tauopathy linked to deln296 mutation

Abstract: Tau phosphorylation has been examined by immunohistochemistry in the brain of a patient affected with familial tauopathy with progressive supranuclear palsy-like phenotype linked to the delN296 mutation in the tau gene. Phospho-specific tau antibodies Thr181, Ser202, Ser214, Ser396 and Ser422, and antibodies to glycogen synthase kinase-3alpha/beta (GSK-3alpha/beta) and to phosphorylated (P) mitogen-activated protein kinase/extracellular signal-regulated kinases (MAPK/ERK), stress-activated protein kinase/c-Jun… Show more

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Cited by 46 publications
(31 citation statements)
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“…Astrocytes containing hyper-phosphorylated tau inclusions co-express phosphorylated tau kinases: mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK), p-38 kinase, stress-activated kinase/c-Jun N-terminal kinase (SAPK/JNK) and glycogen synthase kinase-3 [14,82,[96][97][98][99][100]. Co-expression in astrocytes suggests active phosphorylation of tau by specific kinases; such co-localization also occurs in neurons with pre-tangles and tangles in the same tauopathies.…”
Section: Post-translational Tau Modifications and Tau Kinases In Tau-mentioning
confidence: 99%
See 1 more Smart Citation
“…Astrocytes containing hyper-phosphorylated tau inclusions co-express phosphorylated tau kinases: mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK), p-38 kinase, stress-activated kinase/c-Jun N-terminal kinase (SAPK/JNK) and glycogen synthase kinase-3 [14,82,[96][97][98][99][100]. Co-expression in astrocytes suggests active phosphorylation of tau by specific kinases; such co-localization also occurs in neurons with pre-tangles and tangles in the same tauopathies.…”
Section: Post-translational Tau Modifications and Tau Kinases In Tau-mentioning
confidence: 99%
“…Various types of astrocytic inclusions are generated in familial FTLD-tau linked to mutations in exons 1 and 10 and in introns following exons 9 and 10, the morphology of which largely depends on the MAPT mutation. Intracytoplasmic tau-immunoreactive inclusions in FTLD-tau are represented by tufted-like astrocytes, astrocytic plaques, ramified astrocytes, TSAs, astrocytes with globular inclusions and other types with no specific names [17,33,34,36,37,66,[77][78][79][80][81][82][83][84][85][86]. Tufted astrocytes and astrocytic plaques practically do not co-exist in PSP and CBD [57], but these lesions appear in combination in FTLD-tau [29] (Figure 4).…”
Section: Introductionmentioning
confidence: 99%
“…Finally, genetic studies have revealed that pathologically confirmed cases of PSP, CBD, and FTLD share mutations from a single gene (MAPT) [6,10,21,29,30,36]. Therefore, to encompass the whole spectrum of these disorders, an umbrella term called "Pick complex" has been proposed [17,20,26].…”
Section: Introductionmentioning
confidence: 99%
“…30 The proposal that the FTLDs, CBD, and PSP may represent different points on a single disease spectrum is furthermore substantiated by genetic studies that have revealed pathologically confirmed cases of PSP, CBD, and FTLD with mutations from a single gene (MAPT). 7,[31][32][33][34][35] Therefore, the concept of Pick's complex 1 to encompass the clinicopathologic spectrum of these diseases may be useful.…”
Section: Figure 1 Pick Complex Can Be Divided Into Clinical Syndromementioning
confidence: 99%