I. The Diffusible Calcium and the Proteins of the Blood Serum in Jaundice

Diffusible Calcium of the Blood Stream

“…The increase in both fractions of the calcium after the injection of parathyroid extract-Collip agrees with the findings of Chart 11.-A, changes in the calcium fractions and inorganic serum phosphate after the injection of 100 units of parathyroid extract-Collip (dog 3, weighing 15 Kg. When the blood calcium level is increased by an injection of parathyroid extract, the increase is reflected in both the diffusible and the nondiffusible fractions, while, as shown, when the increase is produced by a calcium-containing compound, the increase takes place only in the diffusible calcium.…”

“…When this is high, as in experiment 15 or may even be absent. When an increase in blood calcium was produced by the administration of a calcium salt, there was found a concomitant increase in inorganic serum phosphate which persisted even longer than the increased calcium level.…”

“…The published figures for the diffusible calcium in jaundice by us 15 change on a bile-free diet during a period of forty-five days. Osnato, Killian, Garcia and Mattice,10 in summarizing the work done by means of ultrafiltration and compensation dialysis, pointed out that a wide variation in values has been obtained, ranging from 39 to 75 per cent of the total calcium.…”

“….-A short fasting period in a dog (dog 8, weighing15 Kg.) produces a small drop in calcium from the initial value with erratic changes in the inorganic serum phosphate.…”