<i>Timeless</i>
            genes and
            <i>jetlag</i>

Gelder, Russell N. Van

doi:10.1073/pnas.0608751103

Cited by 4 publications

(3 citation statements)

References 11 publications

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“…Recently, researchers have found that the FBP JETLAG (JET) mediates the ubiquitination of TIM upon photo-activation. When the flies perceive light, CRY binds to TIM, leading to the subsequent ubiquitination and degradation of TIM [192,193]. Mutant jet flies are rhythmically insensitive in constant light and the abnormal rhythmic behaviors can be rescued by expression of JET in clock-specific neurons.…”

Section: Jet-regulated Tim Degradation Is Light Dependentmentioning

confidence: 98%

The utility F-box for protein destruction

Chan

et al. 2008

Cell. Mol. Life Sci.

115

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A signature feature of all living organisms is their utilization of proteins to construct molecular machineries that undertake the complex network of cellular activities. The abundance of a protein element is temporally and spatially regulated in two opposing aspects: de novo synthesis to manufacture the required amount of the protein, and destruction of the protein when it is in excess or no longer needed. One major route of protein destruction is coordinated by a set of conserved molecules, the F-box proteins, which promote ubiquitination in the ubiquitin-proteasome pathway. Here we discuss the functions of F-box proteins in several cellular scenarios including cell cycle progression, synapse formation, plant hormone responses, and the circadian clock. We particularly emphasize the mechanisms whereby F-box proteins recruit specific substrates and regulate their abundance in the context of SCF E3 ligases. For some exceptions, we also review how F-box proteins function through non-SCF mechanisms.

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Section: Jet-regulated Tim Degradation Is Light Dependentmentioning

confidence: 98%

The utility F-box for protein destruction

Chan

et al. 2008

Cell. Mol. Life Sci.

115

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“…The clock is no exception to this, and ubiquitin tags can, in some cases, modulate subcellular localizations of clock proteins, as a way to modulate interactions within the clock machinery. One example relates to the TIM nuclear localization in Drosophila : CRY binds to and causes TIM to translocate into the nucleus, in response to light (Dissel et al., 2004), but the presence of E3 ligase JET prevents this translocation and rather targets TIM for degradation (Koh et al., 2006; Van‐Gelder, 2006).…”

Section: A Diversity Of Roles For Ubiquitination In Circadian Clocksmentioning

confidence: 99%

To Ub or not to Ub: Regulation of circadian clocks by ubiquitination and deubiquitination

Srikanta

Cermakian

2020

Journal of Neurochemistry

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Circadian clocks are internal timing systems that enable organisms to adjust their behavioral and physiological rhythms to the daily changes of their environment. These clocks generate self‐sustained oscillations at the cellular, tissue, and behavioral level. The rhythm‐generating mechanism is based on a gene expression network with a delayed negative feedback loop that causes the transcripts to oscillate with a period of approximately 24 hr. This oscillatory nature of the proteins involved in this network necessitates that they are intrinsically unstable, with a short half‐life. Hence, post‐translational modifications (PTMs) are important to precisely time the presence, absence, and interactions of these proteins at appropriate times of the day. Ubiquitination and deubiquitination are counter‐balancing PTMs which play a key role in this regulatory process. In this review, we take a comprehensive look at the roles played by the processes of ubiquitination and deubiquitination in the clock machinery of the most commonly studied eukaryotic models of the circadian clock: plants, fungi, fruit flies, and mammals. We present the effects exerted by ubiquitinating and deubiquitinating enzymes on the stability, but also the activity, localization, and interactions of clock proteins. Overall, these PTMs have key roles in regulating not only the pace of the circadian clocks but also their response to external cues and their control of cellular functions.

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“…Therefore, molecular rhythms in clock cells can be entrained independent of the rest of the circuits through cry, and certainly that is the case for many peripheral oscillators (Stanewsky et al, 1998). CRY interacts with TIM in a light-dependent manner and modifies it, enabling another protein JETLAG (JET) to ubiquitinate TIM thus facilitating its degradation via proteosomal pathways (Koh et al, 2006;Peschel et al, 2006;Van Gelder, 2006). However, locomotor activity rhythms of flies can be entrained without cry (Stanewsky et al, 1998).…”

Section: Inputs Into Core Pacemaker Neuronsmentioning

confidence: 99%

TheDrosophilaCircadian Pacemaker Circuit: Pas de Deux or Tarantella?

Sheeba

Kaneko

Sharma

et al. 2008

Critical Reviews in Biochemistry and Molecular Biology

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Molecular genetic analysis of the fruit fly Drosophila melanogaster has revolutionized our understanding of the transcription/translation loop mechanisms underlying the circadian molecular oscillator. More recently, Drosophila has been used to understand how different neuronal groups within the circadian pacemaker circuit interact to regulate the overall behavior of the fly in response to daily cyclic environmental cues as well as seasonal changes. Our present understanding of circadian timekeeping at the molecular and circuit level is discussed with a critical evaluation of the strengths and weaknesses of present models. Two models for circadian neural circuits are compared: one that posits that two anatomically distinct oscillators control the synchronization to the two major daily morning and evening transitions, versus a distributed network model that posits that many cellautonomous oscillators are coordinated in a complex fashion and respond via plastic mechanisms to changes in environmental cues.

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Timeless genes and jetlag

Cited by 4 publications

References 11 publications

The utility F-box for protein destruction

The utility F-box for protein destruction

To Ub or not to Ub: Regulation of circadian clocks by ubiquitination and deubiquitination

TheDrosophilaCircadian Pacemaker Circuit: Pas de Deux or Tarantella?

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