<i>Toxocara </i>seropositivity in Sri Lankan children with asthma

Fernando, Deepika; Wickramasinghe, Pujitha; Kapilananda, G. M. G.; Dewasurendra, Rajika; Amarasooriya, Melanie; Dayaratne, and Asangi

doi:10.1111/j.1442-200x.2008.02687.x

Cited by 30 publications

(43 citation statements)

References 19 publications

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“…; ADAMI, C.; FALAVIGNA-GUILHERME, G.; RUBINSKY-ELEFANT, G. & FALAVIGNA-GUILHERME, A.L. reported in toxocariasis by many authors 3,8,25 . In this study six patients had increased levels of IgE, and in five out of seven cases breathlessness was reported as the main complaint.…”

Section: Discussionmentioning

confidence: 95%

Toxocariasis in children attending a Public Health Service Pneumology Unit in Paraná State, Brazil

Guilherme¹,

Marchioro

Araújo³

et al. 2013

Rev. Inst. Med. trop. S. Paulo

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SUMMARYThe enzyme-linked immunosorbent assay (ELISA) is the most widely used tool to detect anti-Toxocara IgG antibodies for both serodiagnostic and seroepidemiological surveys on human toxocariasis. In the last eight years a high prevalence of toxocariasis (32.2-56.0%) has been reported in children attending public health units from municipalities in the state of Paraná, Brazil. Therefore, the aim of this work was to compare the frequency found among the general child population with that of children attending a public pneumology service in Maringá, Paraná, Brazil and describe the laboratorial, clinical and epidemiological findings. The research was conducted at the Consórcio Público Intermunicipal de Saúde do Setentrião Paranaense (CISAMUSEP) from July 2009 to July 2010 among children aged between one and 15 years. From a total of 167 children studied, only 4.2% (7/167) tested positive for anti-Toxocara spp. IgG antibodies and presented mild eosinophilia (2/7), increased serum IgE levels (6/7) and a positive allergy test for mites (5/7). The presence of pets (dogs or cats) at home did not correlate with the seroprevalence. In conclusion, cases of toxocariasis involving the respiratory tract are rare in children attending a public health pneumology unit in the northwestern region of Paraná State, despite the high prevalence of this type of toxocariasis among the infantile population attending Basic Health Units in the same geographical area.

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Section: Discussionmentioning

confidence: 95%

Toxocariasis in children attending a Public Health Service Pneumology Unit in Paraná State, Brazil

Guilherme¹,

Marchioro

Araújo³

et al. 2013

Rev. Inst. Med. trop. S. Paulo

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“…Whether indeed there is cross-reactivity between Toxocara and mite antigens, remains to be investigated. Recently, Fernando et al carried out a study with Sri Lankan children on the association between Toxocara seropositivity and asthma [7]. The studied population consisted of 196 children aged 5 -12 years that were taken to the hospital.…”

Section: Epidemiological Studies On the Inter-action Between Toxocaramentioning

confidence: 99%

“…shares in addition common clinical features with allergic asthma such as wheezing, coughs, mucus hyper-secretion and bronchial hyper-reactivity. Although few epidemiological studies have suggested no association between Toxocara infections and asthma [7][8][9] no studies so far have reported on an inverse association. The hygiene hypothesis proposes that infections with different pathogens including helminths, confer protection against allergies [10,11].…”

Section: Introductionmentioning

confidence: 98%

Toxocara infection and its Association with Allergic Manifestations

Pinelli¹,

Aranzamendi

2012

EMIDDT

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Toxocara canis and Toxocara cati are roundworms of dogs and cats that can also infect humans worldwide. Although these parasites do not reach the adult stage in the human host the larvae migrate to different organs and can persist for many years. Migration of larvae through the lungs may result in respiratory distress such as wheezing, coughs, mucous production and hyper-reactivity of the airways. Epidemiological and experimental studies suggest that infection with this helminth contributes to the development of allergic manifestations, including asthma. These findings are however conflicting since in others studies no association between these two immunopathologies has been found. This article reviews information on Toxocara spp. and findings from epidemiological and experimental studies on the association between Toxocara infection and allergic manifestations. In addition, the immunological mechanisms and the factors involved in the helminth allergy-association are discussed.

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“…Both allergic diseases and helminth infections have common parameters, such as induction of Th2-polarized immune responses with high levels of IgE, up-regulation of cytokines IL-4, IL-5, IL-13, eosinophilia, as well as 1 3 alized countries and occurs mainly in young children [38,108]. In Austria, epidemiological studies reported a seroprevalence of 3.7 % among the normal population and up to 44 % among people at risk, such as farmers or hunters [29].…”

Section: Th2-driven Paradoxmentioning

confidence: 99%

“…Tissue-dwelling larvae can survive in humans for many years, migrating through different organs including lungs. This might cause damage leading to pulmonary inflammation, eosinophilia or airway hyperactivity [5,38,79]. Two consecutive cross-sectional surveys in the Netherlands have shown that T. canis seropositive school children had higher serum IgE levels and higher prevalence of allergic sensitization than T. canis seronegative individuals [16,17].…”

Section: Th2-driven Paradoxmentioning

confidence: 99%

Allergie und Würmer: Sollen wir uns gute alte Freunde zurückholen?

Schabussova

Wiedermann

2014

Wien Med Wochenschr

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During the past 10 years, many exciting and important studies have found that certain helminth infections protect against the development of allergic diseases. Not surprisingly, several clinical trials investigated the effects of deliberate exposure to parasites like porcine whipworm (Trichuris suis) or hookworm (Necator americanus) to develop "helminth therapies". Although they proved to be a safe option to control aberrant inflammation, the final goal is to identify the parasite-derived immunnomodulatory molecules responsible for protective effects.

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Toxocara seropositivity in Sri Lankan children with asthma

Abstract: The analysis confirmed previously identified risk factors for asthma but there was no association between the helminth parasitic infection, toxocariasis and bronchial asthma in children.

Cited by 30 publications

References 19 publications

Toxocariasis in children attending a Public Health Service Pneumology Unit in Paraná State, Brazil

Toxocariasis in children attending a Public Health Service Pneumology Unit in Paraná State, Brazil

Toxocara infection and its Association with Allergic Manifestations

Allergie und Würmer: Sollen wir uns gute alte Freunde zurückholen?

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