Abstract-A 2-day forum was convened to discuss the current status and future implications of reducing trans fatty acids without increasing saturated fats in the food supply while maintaining functionality and consumer acceptance of packaged, processed, and prepared foods. Attendees represented the agriculture and oilseed industry and oil processing, food manufacturing, food service, government, food technology, and health and nutrition disciplines. Presentations included food science behind fatty acid technology, the health science of dietary fatty acids, alternatives to trans fatty acids, and the use of alternatives in food manufacturing and food service. The reduction of trans fatty acids in the food supply is a complex issue involving interdependent and interrelated stakeholders. Actions to reduce trans fatty acids need to carefully consider both intended and unintended consequences related to nutrition and public health. The unintended consequence of greatest concern is that fats and oils high in saturated fats, instead of the healthier unsaturated fats, might be used to replace fats and oils with trans fatty acids. Many different options of alternative oils and fats to replace trans fatty acids are available or in development. Decisions on the use of these alternatives need to consider availability, health effects, research and development investments, reformulated food quality and taste, supply-chain management, operational modifications, consumer acceptance, and cost. The conference demonstrated the value of collaboration between the food industry and health and nutrition professionals, and this conference model should be used to address other food development, processing, and/or technology issues. Key Words: AHA Conference Proceedings Ⅲ diet Ⅲ fatty acids Ⅲ nutrition Ⅲ trans fat Ⅲ trans fatty acids I n recent years, scientific studies, public and regulatory policy activity, and media coverage have focused extensively on issues related to trans fatty acid reduction in the American diet and potential benefits with respect to health outcomes. To discuss and address trans fatty acid reduction in the food supply with input from the agricultural and oilseed industry and oil processing and manufacturing, food manufacturing, food service, government, food technology, and *The American Heart Association Trans Fat Conference Planning Group was composed of Robert H. Eckel, MD, FAHA, Immediate Past President of the AHA; Susan Borra, RD, Co-Chair; Alice H. Lichtenstein, DSc, FAHA, Co-Chair; Shelley Goldberg, MPH, RD; Bill Layden; Rose Marie Robertson, MD, FAHA; Brigid McHugh Sanner; Kimberly F. Stitzel, MS, RD; and Shirley Y. Yin-Piazza, MS, MBA. This article represents a summary of a conference sponsored by the American Heart Association. The opinions expressed in this article are those of the authors and do not necessarily represent those of the editor or the American Heart Association. The publication of these proceedings was approved by the American Heart Association Science Advisory and Coordinating Committee...