<i>Trichosporon</i>: another yeast‐like organism responsible for immune reconstitution inflammatory syndrome in patients with hematological malignancy

Alby-Laurent, Fanny; Dollfus, Catherine; Ait‐Oufella, Hafid; Rambaud, Jérôme; Legrand, Ollivier; Tabone, Marie‐Dominique; Hennequin, Christophe

doi:10.1002/hon.2309

Cited by 7 publications

(4 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Outside of the potentially important roles of fungi in WWTPs, many fungi occurring in activated sludge are potential pathogens of environment and humans (Alby-Laurent et al 2016). For example, some species of Cryptococcus are capable of causing meningitis in people (Huang et al 2012).…”

Section: Resultsmentioning

confidence: 99%

Ignored fungal community in activated sludge wastewater treatment plants: diversity and altitudinal characteristics

Niu

Xu³

et al. 2016

Environ Sci Pollut Res

View full text Add to dashboard Cite

Fungi are important contributors to the various functions of activated sludge wastewater treatment plants (WWTPs); however, the diversity and geographic characteristics of fungal populations have remained vastly unexplored. Here, quantitative polymerase chain reaction and 454 pyrosequencing were combined to investigate the abundance and diversity of the activated sludge fungal communities from 18 full-scale municipal WWTPs in China. Phylogenetic taxonomy revealed that the members of the fungal communities were assigned to 7 phyla and 195 genera. Ascomycota and Basidiomycota were the most abundant phyla, dominated by Pluteus, Wickerhamiella, and Penicillium. Twenty-three fungal genera, accounting for 50.1 % of the total reads, were shared by 18 WWTPs and constituted a core fungal community. The fungal communities presented similar community diversity but different community structures across the WWTPs. Significant distance decay relationships were observed for the dissimilarity in fungal community structure and altitudinal distance between WWTPs. Additionally, the community evenness increased from 0.25 to 0.7 as the altitude increased. Dissolved oxygen and the C/N ratio were determined to be the most dominant contributors to the variation in fungal community structure via redundancy analysis. The observed data demonstrated the diverse occurrence of fungal species and gave a marked view of fungal community characteristics based on the previously unexplored fungal communities in activated sludge WWTPs.

show abstract

Section: Resultsmentioning

confidence: 99%

Ignored fungal community in activated sludge wastewater treatment plants: diversity and altitudinal characteristics

Niu

Xu³

et al. 2016

Environ Sci Pollut Res

View full text Add to dashboard Cite

show abstract

“…Fungemia (often CVC‐related fungemia) and disseminated IFDs in immunocompromised patients have been mostly reported due to Trichosporon sasahii , but invasive IFDs due to Trichosporon mucoides or Trichosporon asteroides have all been reported 252,254‐256 . Following infections with Trichosporon spp., appearance of hepatic and splenic lesions with the recovery from granulocytopenia has been described similar to IRIS in disseminated candidosis 257 . Treatment of invasive trichosporonosis remains a challenge, and no data from prospective trials are available.…”

Section: Resultsmentioning

confidence: 98%

Treatment of invasive fungal diseases in cancer patients—Revised 2019 Recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO)

Ruhnke

Cornely

Schmidt‐Hieber

et al. 2020

Mycoses

View full text Add to dashboard Cite

Summary Background Invasive fungal diseases remain a major cause of morbidity and mortality in cancer patients undergoing intensive cytotoxic therapy. The choice of the most appropriate antifungal treatment (AFT) depends on the fungal species suspected or identified, the patient's risk factors (eg length and depth of granulocytopenia) and the expected side effects. Objectives Since the last edition of recommendations for ‘Treatment of invasive fungal infections in cancer patients’ of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO) in 2013, treatment strategies were gradually moving away from solely empirical therapy of presumed or possible invasive fungal diseases (IFDs) towards pre‐emptive therapy of probable IFD. Methods The guideline was prepared by German clinical experts for infections in cancer patients in a stepwise consensus process. MEDLINE was systematically searched for English‐language publications from January 1975 up to September 2019 using the key terms such as ‘invasive fungal infection’ and/or ‘invasive fungal disease’ and at least one of the following: antifungal agents, cancer, haematological malignancy, antifungal therapy, neutropenia, granulocytopenia, mycoses, aspergillosis, candidosis and mucormycosis. Results AFT of IFDs in cancer patients may include not only antifungal agents but also non‐pharmacologic treatment. In addition, the armamentarium of antifungals for treatment of IFDs has been broadened (eg licensing of isavuconazole). Additional antifungals are currently under investigation or in clinical trials. Conclusions Here, updated recommendations for the treatment of proven or probable IFDs are given. All recommendations including the levels of evidence are summarised in tables to give the reader rapid access to key information.

show abstract

“…An inflammatory imbalance tipping toward an increase in proinflammatory cytokines like interleukin-6 as in our patient is seen in IRIS. IRIS in ALL has been reported commonly with CDC but can be with other fungal infections like Saccharomyces and Trichosporon as well 6,7…”

Section: Discussionmentioning

confidence: 99%

“…IRIS in ALL has been reported commonly with CDC but can be with other fungal infections like Saccharomyces and Trichosporon as well. 6,7 CDC is a form of candida infection that can occur in children undergoing chemotherapy with prolonged neutropenia. The occurrence of CDC involves 2 phases.…”

Section: Discussionmentioning

confidence: 99%

Subcutaneous Microabscesses and Myositis as Part of Immune Reconstitution Inflammatory Syndrome due to Chronic Disseminated Candidiasis in a Child With Acute Lymphoblastic Leukemia

Reddy¹,

Addala

Shyam

et al. 2023

Journal of Pediatric Hematology/Oncology

View full text Add to dashboard Cite

Background: Immune reconstitution inflammatory syndrome (IRIS) occurs when there is immune recovery after a prolonged period of leucopenia as a response to an underlying latent or chronic infection due to a proinflammatory cascade. It can occur in a child on chemotherapy for acute lymphoblastic leukemia (ALL) with underlying chronic disseminated candidiasis (CDC).Observation: We present a 7-year-old girl with pre-B ALL on chemotherapy who had prolonged febrile neutropenia and CDC with microabscesses in the liver, spleen, and kidney and a prolonged intensive care unit stay. Upon neutrophil recovery, she continued to have high-grade fever (blood and urine cultures negative). She also presented severe myositis of bilateral thigh muscles and developed unusual granulomas in the subcutaneous region of the lower back and right thigh. Although IRIS was suspected, she could not be initiated on steroids due to right upper lobe collapse consolidation due to multidrug-resistant Acinetobacter baumanni, which was treated with sensitive antibiotics. Treatment with steroids resolved her fever and normalized inflammatory markers. She is currently well on maintenance chemotherapy.Conclusions: IRIS can complicate the treatment of ALL in children. Diagnosing it while having a concurrent bacterial infection is challenging. Rarely CDC can present with subcutaneous granulomas. Treatment with steroids at the right time is very crucial.

show abstract

Trichosporon: another yeast‐like organism responsible for immune reconstitution inflammatory syndrome in patients with hematological malignancy

Cited by 7 publications

References 17 publications

Ignored fungal community in activated sludge wastewater treatment plants: diversity and altitudinal characteristics

Ignored fungal community in activated sludge wastewater treatment plants: diversity and altitudinal characteristics

Treatment of invasive fungal diseases in cancer patients—Revised 2019 Recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO)

Subcutaneous Microabscesses and Myositis as Part of Immune Reconstitution Inflammatory Syndrome due to Chronic Disseminated Candidiasis in a Child With Acute Lymphoblastic Leukemia

Contact Info

Product

Resources

About