<i>Trichuris muris</i> as a tool for holistic discovery research: from translational research to environmental bio-tagging

Mair, Iris; Else, Kathryn J.; Forman, Ruth

doi:10.1017/s003118202100069x

Cited by 7 publications

(7 citation statements)

References 135 publications

(163 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Concerning helminth species present in the helminth community of M. lusitanicus , Deter et al [ 88 , 89 ] demonstrated that T. arvicolae affects the fecundity of its host, and proposed that this intestinal nematode could control population growth in several rodent species, representing an in-built pest control [ 90 ]. Likewise, it has been demonstrated that rodents infected with H. taeniaeformis have lower levels of leptin and higher levels of neuropeptide-Y in plasma than uninfected ones [ 91 ].…”

Section: Discussionmentioning

confidence: 99%

Ecological Analysis of the Helminth Community of Microtus lusitanicus (Gerbe, 1879) (Rodentia) in Asturias (NW Spain)

Adalid

Feliu

Somoano

et al. 2021

Animals

View full text Add to dashboard Cite

The Lusitanian pine vole, Microtus lusitanicus, an endemic fossorial rodent of the Iberian Peninsula, has a burrowing behaviour and prefers to live underground. It feeds on bark and roots causing severe damage to trees. In Asturias (NW Spain), where M. lusitanicus is considered a pest in several orchards, a faunistic-ecological study was carried out to describe the helminth community of this species and the main factors that could influence its helminth component species. For this purpose, our own collection of 710 voles from several orchards of various locations in Asturias was used. Eight helminth species, four cestodes and four nematodes, were found. Statistical non-parametric tests were used to analyse the effects of extrinsic and intrinsic factors on the diversity of the helminth community and species prevalence and abundance. The results show the influence of climate variables, the year and season of capture, as well as host age, on the diversity of the helminth community and the infection parameters of some helminth species, underlining the importance of their life cycles. In addition to shedding light on the helminth community of this rodent in Asturias, the results obtained could be used to improve the biological methods applied to fight the M. lusitanicus pest.

show abstract

Section: Discussionmentioning

confidence: 99%

Ecological Analysis of the Helminth Community of Microtus lusitanicus (Gerbe, 1879) (Rodentia) in Asturias (NW Spain)

Adalid

Feliu

Somoano

et al. 2021

Animals

View full text Add to dashboard Cite

show abstract

“…While these are general features of type 2 responses to intestinal helminths, the different experimental models-Nippostronyglus brasilensis, Heligmosomoides polygyrus bakeri and Trichuris muris, have different lifecycles, reside in different parts of the intestine, hence function as models of different human helminth parasite with different pathogenicity and chronicity pattern 19 . The complex array of immune, epithelial, neuronal, and stromal changes has been previously reviewed 4,[19][20][21][22][23][24][25] . Notably, there are also important immunometabolic consequences of helminth infections 26,27 .…”

Section: Mucosal Responses To Intestinal Helminth Infection In Micementioning

confidence: 99%

Effects of helminths on the human immune response and the microbiome

2022

View full text Add to dashboard Cite

Helminths have evolved sophisticated immune regulating mechanisms to prevent rejection by their mammalian host. Our understanding of how the human immune system responds to these parasites remains poor compared to mouse models of infection and this limits our ability to develop vaccines as well as harness their unique properties as therapeutic strategies against inflammatory disorders. Here, we review how recent studies on human challenge infections, self-infected individuals, travelers, and endemic populations have improved our understanding of human type 2 immunity and its effects on the microbiome. The heterogeneity of responses between individuals and the limited access to tissue samples beyond the peripheral blood are challenges that limit human studies on helminths, but also provide opportunities to transform our understanding of human immunology. Organoids and single-cell sequencing are exciting new tools for immunological analysis that may aid this pursuit. Learning about the genetic and immunological basis of resistance, tolerance, and pathogenesis to helminth infections may thus uncover mechanisms that can be utilized for therapeutic purposes.

show abstract

“…Intestinal whipworms also inhabit this microbial-dense niche, and it is highly likely that these worms and the surrounding microbiota interact with each other (either directly or indirectly), as well as their mammalian host. An overview of how Trichuris interacts with the mammalian host, in particular the host immune system during acute and/or chronic infection, and the details of the T r ichuris life cycle is presented in this special issue by Mair et al ( 2021 ).…”

Section: Helminth-microbe Interactionsmentioning

confidence: 99%