I.V. Flunitrazepam and I.V. Diazepam in Conservative Dentistry

Abstract

In a randomized cross-over trial in 82 outpatients aged 15-45 yr undergoing conservative dentistry, a solution of flunitrazepam 0.25 mg ml-1 i.v. (average dose 0.014 mg kg-1) was compared with a solution of diazepam 5 mg ml-1 i.v. (0.29 mg kg-1). Cardiovascular changes, operating conditions and side-effects were similar. Forty minutes after the start of injection, about 85% of all patients could not remember the local anaesthetic injection. Thirty minutes after the end of treatment, only 25% of all patients had recovered. One week later, most patients receiving each drug had only vague memories of their treatment; they had felt more relaxed immediately after the i.v. injection than before. Drowsiness was equally common after flunitrazepam and diazepam. Ataxia was more prolonged with flunitrazepam but arm pain and venous thrombophlebitis were less frequent.

Effects of Midazolam and Flunitrazepam on the Release of Dopamine From Rat Striatum Measured by in Vivo Microdialysis

“…Flunitrazepam was more effective than midazolam in doses similar to those used clinically to produce i.v. sedation and anaesthesia [19][20][21]. Concentrations of metabolites (DOPAC and HVA) in striatal dialysates tended to decrease after flunitrazepam, but were not affected by i.v.…”