<i>Verbascum speciosum</i>Methanolic Extract: Phytochemical Components and Antibacterial Properties

Nofouzi, Katayoon; Mahmudi, Razzagh; Tahapour, Keyvan; Amini, Ebrahim; Yousefi, Kamyar

doi:10.1080/0972060x.2014.901625

Cited by 11 publications

(4 citation statements)

References 7 publications

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“…Similar results were found by Marian et al [41]. Contrary results were obtained by the authors of this work showing that Verbascum L. extracts exhibited good antibacterial activity against S. aureus, S. epidermidis, E. faecalis [42], L. monocytogenes, B. anthracis, B. cereus, S. Typhimurium [16], S. pyogenes, and E. coli [43]. The results of this research showed that Astragalus extracts had moderate antibacterial activity.…”

Section: Discussionsupporting

confidence: 86%

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Mixtures of Scutellaria baicalensis and Glycyrrhiza L. Extracts as Antibacterial and Antiviral Agents in Active Coatings

et al. 2021

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The aim of this study was to develop active packaging materials covered in active coatings (offering antibacterial and antiviral properties) that contain selected plant extracts. In addition, the synergistic effect of the active substances in these extracts was also analysed. The results of the study demonstrated that Scutellaria baicalensis and Glycyrrhiza L. extracts (two of six analysed plant extracts) were the most active agents against selected Gram-positive and Gram-negative bacterial strains. Additionally, the synergistic effect of S. baicalensis and Glycyrrhiza L. extracts was noted, meaning that the effect of these two plant extract mixtures on Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas syringae growth was higher than the activity of individual pure extracts. Mixtures of the extracts were introduced into the coating carrier. A polyethylene (PE) foil was then coated with active layers containing mixtures of S. baicalensis and Glycyrrhiza L. extracts as antimicrobial agents. The results of this research showed that all of the active coatings had a bacteriolytic effect on B. subtilis and a bacteriostatic effect on S. aureus cells. The coatings were found to be inactive against E. coli and P. syringae cells. This means that the coatings could be used as internal coatings to preserve food products against Gram-positive bacteria that may be responsible for food spoilage. The results of this study also demonstrated that the coatings were highly active against phage phi 6 phage particles, used as SARS-CoV-2 surrogate. This means that the coatings could be used as external coatings to limit the spread of SARS-CoV-2 and pathogenic Gram-positive bacteria via human hands.

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Section: Discussionsupporting

confidence: 86%

“…This extract was found to contain boric acid and phenol as major compounds. Both of these compounds have antibacterial activity [16]. These extracts also contain iso-verbascoside, verbascoside, martynoside and leucosceptoside, as well as samioside, leucosceptoside B and alyssonoside [15].…”

Section: Introductionmentioning

confidence: 99%

Mixtures of Scutellaria baicalensis and Glycyrrhiza L. Extracts as Antibacterial and Antiviral Agents in Active Coatings

et al. 2021

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“…Verbascum species have been shown to possess different biological activities, such as antihelmintic (Kozan et al, 2011), anti‐carcinogen (Tatlı & Akdemir, 2004; Zhao et al, 2011), wound healing (Demirci et al, 2014; Kayır et al, 2018; Süntar et al, 2010), anti‐inflammatory (Akdemir et al, 2011; Speranza et al, 2010; Tatli et al, 2008), anxiolytic, preanestetic, sedative (Rezaie et al, 2012), antifungal and antioxidant (Karamian & Ghasemlou, 2013; Nofouzi, 2015; Saltan et al, 2011) effects were studied and possible mechanisms of action were defined. Especially well‐known species that are V. thapsus , V. phlomoides , V. lychnitis and V. nigrum are well‐studied due to their widespread use in traditional medicine (Robbers & Tyler, 1999).…”

Section: Introductionmentioning

confidence: 99%

Isolation, characterization and anticancer activity of secondary metabolites from Verbascum speciosum

et al. 2023

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Herein, two iridoid glucosides aucubin (1) and ajugol (2), and two phenyl ethanoids, verbascoside (3) and poliumoside (4) were isolated from the methanol extract of the aerial parts of Verbascum speciosum and used to study about their anticancer activity for the first time. The structures of all compounds were elucidated using spectroscopic data (IR, 1D and 2D NMR, LC‐TOF/MS). Antiproliferative activities of Aucubun (1) and Verbascoside (3) were tested against A‐549 (human colon cancer), MDA‐MD‐453 (human breast cancer) and 3T3‐L1 (mouse fibroblast)cell lines by XTT assay. In addition, the anticarcer mechanism of action of aucubin (1) was investigated on MDA‐MB‐453 cells for the first time. XTT result showed that both applied compounds exhibited antiproliferative effect at different dose ranges depending on the cancer type, as well as selectivity between cancer and healty cell lines. Flow cytometry analyzes revealed that aucubin (1) exerts its cytotoxic effect in MDA‐MB‐453 cells by directing cells to early apoptosis and inhibiting the P13K/AKT signaling pathway.

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“…Plant phytochemicals vary across different matrices and exhibit a myriad of biological activities [ 17 , 18 ]. The phytochemical investigation of Cyperus esculentus L. revealed the presence of flavonoids, sterols, alkaloids, tannins and saponins [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

The Potential Neuroprotective Effect of Cyperus esculentus L. Extract in Scopolamine-Induced Cognitive Impairment in Rats: Extensive Biological and Metabolomics Approaches

et al. 2022

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The aim of the present study is to investigate the phytochemical composition of tiger nut (TN) (Cyperus esculentus L.) and its neuroprotective potential in scopolamine (Scop)-induced cognitive impairment in rats. The UHPLC-ESI-QTOF-MS analysis enabled the putative annotation of 88 metabolites, such as saccharides, amino acids, organic acids, fatty acids, phenolic compounds and flavonoids. Treatment with TN extract restored Scop-induced learning and memory impairments. In parallel, TN extract succeeded in lowering amyloid beta, β-secretase protein expression and acetylcholine esterase (AChE) activity in the hippocampus of rats. TN extract decreased malondialdehyde levels, restored antioxidant levels and reduced proinflammatory cytokines as well as the Bax/Bcl2 ratio. Histopathological analysis demonstrated marked neuroprotection in TN-treated groups. In conclusion, the present study reveals that TN extract attenuates Scop-induced memory impairments by diminishing amyloid beta aggregates, as well as its anti-inflammatory, antioxidant, anti-apoptotic and anti-AChE activities.

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Verbascum speciosumMethanolic Extract: Phytochemical Components and Antibacterial Properties

Cited by 11 publications

References 7 publications

Mixtures of Scutellaria baicalensis and Glycyrrhiza L. Extracts as Antibacterial and Antiviral Agents in Active Coatings

Mixtures of Scutellaria baicalensis and Glycyrrhiza L. Extracts as Antibacterial and Antiviral Agents in Active Coatings

Isolation, characterization and anticancer activity of secondary metabolites from Verbascum speciosum

The Potential Neuroprotective Effect of Cyperus esculentus L. Extract in Scopolamine-Induced Cognitive Impairment in Rats: Extensive Biological and Metabolomics Approaches

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