Viburnum mullaha D. DON fruit (Indian cranberry): A potential source of polyphenol with rich antioxidant, anti-elastase, anti-collagenase, and anti-tyrosinase activities

Abstract

Viburnum mullaha (Buch.-Ham. Ex D. Don), is an underexplored wild edible fruit of Indian Himalayan region, analyzed for total polyphenol contents, antioxidant, anti-elastase, anti-collagenase, and anti-tyrosinase activities using in vitro assays. High values of total phenolic contents of 1257 ± 40 mg gallic acid equivalents/ 100 g fruit weight and total flavonoid contents of 3501 ± 203 mg catechin equivalents/100 g fruit weight were observed. V. mullaha fruit extracts showed outstanding antioxidant activities (ABTS + , 1,1-diphenyl-2-picrylhydrazyl, superoxide anion, linoleate peroxyl radicals scavenging, and ferric reducing activities) and remarkable anti-elastase, anti-collagenase, and anti-tyrosinase activities. High resolution liquid chromatography-mass spectroscopy analysis revealed presence of 15 phenolic compounds, namely, chlorogenic acid, acetyl salicylic acid, dihydrorobinetin, dihydromyricetin, 2-isoprenylemodin, rutin, cosmosiin hexaacetate, pectolinarin, dihydroquercetin, eriodictyol, iriginol hexaacetate, theaflavin, epicatechin-pentaacetate, lomatin, and peucenin in fruit extracts. This study recommends utilization of V. mullaha fruit as functional food with prospective pharmaceutical, nutraceutical, and cosmeceutical properties. ARTICLE HISTORY

The influence of Viburnum opulus polyphenolic compounds on metabolic activity and migration of HeLa and MCF cells

“…CAPE is a natural phenolic compound and an ester of phenethyl alcohol in the form of caffeic acid. Its presence was also found in the fruit of Viburnum opulus [8]. These reports lead us to conclude that the Viburnum opulus preparations we examined are capable of inducing mitochondrial dysfunction.…”

“…Gallic acid was identified as the main polyphenolic compound in an amount of 8.29 g/kg fresh weight. Further compounds identified were chlorogenic acid, catechin, epicatechin, rutin, quercetin flavonoids, procyanidin B2, procyanidin trimer and proanthocyanidin dimer monoglycoside [8]. While discussing the results of the research we suggest the presence of the mentioned phytochemicals in the obtained preparations.…”

Phenolics and mineral content in bilberry and bog bilberry from Macedonia

“…They have been collected in August 2015 on Shara Mtn., Peak Popova Šapka (1780 m). Plant samples (approximately 100 mature berries of moderate size and 500 g leaf samples) of bilberry and bog bilberry were sampled according to their abundance and biomass (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) replicates from each sampling point). Plant identity (five replicates of both species) was verified by Academician Vlado Matevski 1 at the Department of botany (Institute of biology, Faculty of Natural Sciences and Mathematics, Skopje).…”

Iridoids of Chemotaxonomy Relevance, a New Antirrhinoside Ester and Other Constituents from Kickxia spuria subsp. integrifolia (Brot.) R.Fern.

“…ex D. Don of Adoxaceae . For what concerns the bioactivity context, this compound exerts good analgesic, anti‐inflammatory, hepato‐protective, and cytotoxic effects …”