<i>Vicia plan</i>ts—A comprehensive review on chemical composition and phytopharmacology

Salehi, Bahare; Abu‐Reidah, Ibrahim M.; Sharopov, Farukh; Karazhan, Natallia; Sharifi‐Rad, Javad; Akram, Muhammad; Daniyal, Muhammad; Khan, Fahad Said; Abbaass, Wafa; Zainab, Rida; Carbone, Katya; Fahmy, Nouran M.; Al‐Sayed, Eman; El‐Shazly, Mohamed; Lucarini, Massimo; Durazzo, Alessandra; Santini, Antonello; Martorell, Miquel; Pezzani, Raffaele

doi:10.1002/ptr.6863

Cited by 30 publications

(22 citation statements)

References 122 publications

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“…Vicia faba L. (Fabaceae) also known as broad bean is a plant of the genus Vicia which members are considered to have many health benefits against PD that are attributed to several biological activities, including estrogenic, anticholinesterase, antidepressant, antioxidant, anti-inflammatory and antinociceptive, antidiabetic, anticoagulant, and antihypoxic activities ( Rabey et al, 1992 ; Apaydin et al, 2000 ; Raguthu et al, 2009 ; Ramirez-Moreno et al, 2015 ; Abdel-Sattar et al, 2021 ; Salehi et al, 2021 ).…”

Section: Estrogenic Compounds Effects On Parkinson's Diseasementioning

confidence: 99%

Estrogenic Plants: to Prevent Neurodegeneration and Memory Loss and Other Symptoms in Women After Menopause

et al. 2021

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In mammals, sexual hormones such as estrogens play an essential role in maintaining brain homeostasis and function. Estrogen deficit in the brain induces many undesirable symptoms such as learning and memory impairment, sleep and mood disorders, hot flushes, and fatigue. These symptoms are frequent in women who reached menopausal age or have had ovariectomy and in men and women subjected to anti-estrogen therapy. Hormone replacement therapy alleviates menopause symptoms; however, it can increase cardiovascular and cancer diseases. In the search for therapeutic alternatives, medicinal plants and specific synthetic and natural molecules with estrogenic effects have attracted widespread attention between the public and the scientific community. Various plants have been used for centuries to alleviate menstrual and menopause symptoms, such as Cranberry, Ginger, Hops, Milk Thistle, Red clover, Salvia officinalis, Soy, Black cohosh, Turnera diffusa, Ushuva, and Vitex. This review aims to highlight current evidence about estrogenic medicinal plants and their pharmacological effects on cognitive deficits induced by estrogen deficiency during menopause and aging.

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Section: Estrogenic Compounds Effects On Parkinson's Diseasementioning

confidence: 99%

Estrogenic Plants: to Prevent Neurodegeneration and Memory Loss and Other Symptoms in Women After Menopause

et al. 2021

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“…Natural products are claimed to have high antioxidant potential, which adds to their better tolerance and therapeutic acceptance (Salehi et al, 2020a). The tissue oxidative stress plays a ubiquitous role development and progression of the disease.…”

Section: Free Radical Scavenging and Antioxidative Activity Of A Arch...mentioning

confidence: 99%

Understanding the phytochemistry and molecular insights to the pharmacology of Angelica archangelica L. (garden angelica) and its bioactive components

Kaur

Bhatti

2021

Phytotherapy Research

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Plant-derived molecules have enduring usefulness in treating diseases, and herbal drugs have emerged as a vital component of global therapeutic demand. Angelica archangelica L. (A. archangelica), commonly known as garden angelica, is an aromatic food plant used in culinary procedures as a flavoring agent. In the traditional medicine system, it is regarded as an "Angel plant" due to its miraculous curative power. This review aims to provide a comprehensive summary of the plant's taxonomic profile, ethnopharmacology, Phytochemistry, and pharmacological activities. Various in vivo and in vitro experiments have validated that the plant possesses broad pharmacological potential. The biological activities attributed to the plant include anti-anxiety activity, anti-convulsant activity, cognition enhancer, antiviral activity, cholinesterase inhibitory potential, antiinflammatory activity, gastroprotective activity, and radioprotective activity. The beneficial effects of the plant are credited to its bioactive components, that is, coumarins and volatile oils. The review summarizes the pharmacological activities of crude extract and its bioactive fractions and has also explored their target-oriented effects. This review will be of value in undertaking further investigations on the plant with regard to exploring mechanism-based pharmacological approaches on A. archangelica.

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“…The broad bean (Vicia faba L.) belongs to the Fabaceae family of plants characterized by the production of fruits called legumes. The genus Vicia contains about 140 species, and broad beans are the oldest seeds to be domesticated and the seventh-most produced legume worldwide with a yield of more than 3 million tons per year (1,2). The nutritional value of broad beans per 100 g dry weight is composed of approximately 320 kilocalories distributed in 40% of protein, 4% lipids, and 56% carbohydrates.…”

Section: Introductionmentioning

confidence: 99%

Phytochemicals From Vicia faba Beans as Ligands of the Aryl Hydrocarbon Receptor to Regulate Autoimmune Diseases

et al. 2022

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Legumes are associated with gut health benefits, and increasing evidence indicates that their consumption reduces the risk of chronic diseases that include autoimmunity. Beans are rich sources of compounds with health-promoting effects, and recent metabolomic approaches have enabled the comprehensive characterization of the chemical composition of Vicia faba L. This article reviewed whether the phytocompounds in broad beans might modulate the aryl hydrocarbon receptor (AhR), which plays an essential role in autoantigen tolerance as a potential dietary strategy for autoimmune disease management. Therefore, thirty molecules present in Vicia faba of the chemical classes of flavonoids, chalcones, stilbenes, jasmonates, alkaloids, and amino acids, and either a human- or microbiome-derived product of biotransformation, retrieved from the literature or predicted in silico were evaluated by docking for affinity against the ligand-binding domain of AhR. Most analyzed compounds showed high affinity even after their metabolism which indicate that some AhR modulators remain active despite several steps in their biotransformation. Hence, our results suggest that in similitude with the gut metabolism of the tryptophan, phytocompounds mainly polyphenols also lead to metabolites that induce the AhR pathway. Furthermore, wyerone acid, wyerone epoxide, jasmonic acid, stizolamine, vicine, and convicine and their metabolite derivatives are reported for the first time as potential AhR ligands. Overall, chronic consumption of phytochemicals in Vicia faba L. and their gut biotransformation may protect against autoimmune disease pathogenesis by AhR modulation.

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Vicia plants—A comprehensive review on chemical composition and phytopharmacology

Cited by 30 publications

References 122 publications

Estrogenic Plants: to Prevent Neurodegeneration and Memory Loss and Other Symptoms in Women After Menopause

Estrogenic Plants: to Prevent Neurodegeneration and Memory Loss and Other Symptoms in Women After Menopause

Understanding the phytochemistry and molecular insights to the pharmacology of Angelica archangelica L. (garden angelica) and its bioactive components

Phytochemicals From Vicia faba Beans as Ligands of the Aryl Hydrocarbon Receptor to Regulate Autoimmune Diseases

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