We consider astrophysics of large black holes localized on the brane in the infinite RandallSundrum model. Using their description in terms of a conformal field theory (CFT) coupled to gravity, deduced in Ref.[1], we show that they undergo a period of rapid decay via Hawking radiation of CFT modes. For example, a black hole of mass few × M ⊙ would shed most of its mass in ∼ 10 4 − 10 5 years if the AdS radius is L ∼ 10 −1 mm, currently the upper bound from table-top experiments. Since this is within the mass range of X-ray binary systems containing a black hole, the evaporation enhanced by the hidden sector CFT modes could cause the disappearance of X-ray sources on the sky. This would be a striking signature of RS2 with a large AdS radius. Alternatively, for shorter AdS radii, the evaporation would be slower. In such cases, the persistence of X-ray binaries with black holes already implies an upper bound on the AdS radius of L < ∼ 10 −2 mm, an order of magnitude better than the bounds from table-top experiments. The observation of primordial black holes with a mass in the MACHO range M ∼ 0.1 − 0.5 M ⊙ and an age comparable to the age of the universe would further strengthen the bound on the AdS radius to L < ∼ few × 10 −6 mm. 1 roberto.emparan@cern.ch 2