<i>XPG</i> Gene Polymorphisms and the Risk of Gastric Cardia Adenocarcinoma

Zhou, Rong‐Miao; Niu, Chaoxu; Wang, Na; Liu, Liang; Huang, Xi; Chen, Zhifeng; Huo, Xiangran; Hao, Yali; Li, Yan

doi:10.1089/gtmb.2015.0333

Cited by 10 publications

(10 citation statements)

References 33 publications

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“…The final meta-analysis included 47 articles. There were 22 articles with 12,833 cases and 151,86 controls for rs1047768 T>C [7–9, 12, 14–31], 14 studies with 11,327 cases and 12,684 controls for rs2296147 T>C [9–11, 13, 18, 24, 26–28, 32–37], 11 studies with 5,898 cases and 7,448 controls for rs2227869 G>C [8, 9, 14, 17, 18, 20, 22, 25, 38–40], 17 studies with 9,826 cases and 10,552 controls for rs2094258 C>T [10, 11, 18, 24, 26–28, 34–37, 41–46], 21 studies with 10,369 cases and 11,207 controls for rs751402 C>T [10, 13, 24, 26–29, 31, 32, 36, 37, 42–45, 47–52], and 14 studies with 10,873 cases and 12,535 controls for rs873601 G>A [9–11, 18, 24, 26–28, 32, 34, 36, 52–54]. A flow chart summarizing the process of relevant study identification is shown in Figure 1, and the study characteristics are shown in Table 1.…”

Section: Resultsmentioning

confidence: 99%

XPGgene polymorphisms and cancer susceptibility: evidence from 47 studies

et al. 2017

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Xeroderma pigmentosum group G (XPG) is a single-strand-specific DNA endonuclease that functions in the nucleotide excision repair pathway. Genetic variations in XPG gene can alter the DNA repair capacity of this enzyme. We evaluated the associations between six single nucleotide polymorphisms (SNPs) in XPG (rs1047768 T>C, rs2296147 T>C, rs2227869 G>C, rs2094258 C>T, rs751402 C>T, and rs873601 G>A) and cancer risk. Forty-seven studies were identified in searches of the PubMed, Scopus, Web of Science, China National Knowledge Infrastructure, and WanFang databases. Crude odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using a fixed or random effects model. We found that rs873601 G>A was associated with an increased overall cancer risk (AA vs. GG: OR = 1.14, 95% CI = 1.06–1.24; GA/AA vs. GG: OR = 1.08, 95% CI = 1.02–1.15; A vs. G: OR = 1.06, 95% CI = 1.02–1.10). In a stratified analysis, rs1047768 T>C was associated with an increased risk of lung cancer, rs2227869 G>C was associated with a decreased risk of cancer in population-based studies, and rs751402 C>T and rs873601 G>A were associated with the risk of gastric cancer. Our data indicate that rs873601 G>A is associated with cancer susceptibility.

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Section: Resultsmentioning

confidence: 99%

XPGgene polymorphisms and cancer susceptibility: evidence from 47 studies

et al. 2017

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“…The association with gastric cancer risk was based on 6 case–control studies, and our results were in accordance with Duan et al [ 27 ] However, the results were inconsistent with other studies, which failed to find significant association between rs751402 polymorphisms and gastric cancer. [ 28 – 30 ] Zhou et al found that TT genotype was associated with an increasing risk of gastric cardia adenocarcinoma. [ 30 ] The controversial results might be partially due to the variations in the sample sizes and the control group sampling methods.…”

Section: Discussionmentioning

confidence: 99%

“…[ 28 – 30 ] Zhou et al found that TT genotype was associated with an increasing risk of gastric cardia adenocarcinoma. [ 30 ] The controversial results might be partially due to the variations in the sample sizes and the control group sampling methods. In Duan et al’ studies, the sample size was relatively small, and the healthy controls were patients with mild superficial gastritis receiving endoscopic examination.…”

Section: Discussionmentioning

confidence: 99%

The association between XPG polymorphisms and cancer susceptibility

et al. 2017

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Background:Exposure to environmental carcinogens can cause damages to DNA. If not properly repaired, the DNA damages may increase the risk of carcinogenesis. Xeroderma pigmentosum group G (XPG) gene is an essential gene in the nucleotide excision repair (NER) pathway. The association between XPG polymorphisms and cancer susceptibility has been the focus of attention in the molecular epidemiology of cancer. However, the conclusions have been divergent. Therefore, we conducted a comprehensive meta-analysis to precisely evaluate the association of 3 frequently investigated XPG polymorphisms (rs751402, rs873601, and rs2296147) with cancer risk.Methods:Pubmed, EMBASE, and Chinese National Knowledge Infrastructure (CNKI) were searched for relevant studies in English and Chinese. Odds ratio (OR) and 95% confidence interval (CI) were used to assess the association between XPG polymorphisms (rs751402, rs873601, and rs2296147) and cancer risk.Results:Twenty-three studies were included. Overall, there was no significant association between rs751402 polymorphism and overall cancer risk under the 5 gene models. However, we observed strong correlation between rs751402 polymorphism and gastric cancer (C vs T: OR=1.21, 95% CI = 1.00–1.26, P = .045; TC vs CC: OR = 1.12, 95% CI = 1.00–1.24, P = .041; TC/TT vs CC: OR = 1.13, 95% CI = 1.02–1.26, P = .020). There was a significant correlation between rs873601 polymorphism and cancer risk under the homozygous model (GG vs AA: OR = 1.16, 95% CI = 1.07–1.26, P = .001). Moreover, significant association with breast cancer was detected for rs873601 polymorphism under the allele contrast model (G vs A: OR = 1.10, 95% CI = 1.02–1.20, P = .021). In the subgroup of Asian, rs873601 polymorphism was related to the susceptibility to cancer (G vs A: OR = 1.07, 95% CI = 1.03–1.12, P = .010; GG vs AA: OR = 1.15, 95% CI = 1.06–1.26, P = .001; AG/AA vs GG: OR = 1.08, 95% CI = 1.01–1.15, P = .031; AA vs AG/GG: OR = 1.13, 95% CI = 1.05–1.21, P = .001). Significant association between rs2296147 polymorphism and cancer risk were observed in Asian population (CT vs TT: OR = 0.93, 95% CI = 0.87–0.99, P = .036).Conclusions:Our meta-analysis suggested that the rs873601 polymorphism was significantly associated with overall cancer risk. The moderate effects of rs751402 and rs2296147 polymorphism on cancer susceptibility might be highly dependent on cancer type and ethnicity, respectively. Large studies are needed to validate our findings, especially in Caucasian and African population.

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“…In these publications, sample sizes ranged from 96 to 1900 cases and from 101 to 1977 control subjects. Among the studies, 10 focused on gastric cancer [ 21 , 23 , 27 , 29 , 30 , 32 – 34 , 38 , 39 ], three focused on breast cancer [ 25 , 35 , 36 ], two focused on hepatocellular carcinoma [ 20 , 37 ], and one each focused on lung cancer [ 19 ], oral squamous cell carcinoma [ 22 ], salivary gland tumor [ 24 ], nasopharyngeal carcinoma [ 26 ], neuroblastoma [ 28 ], colorectal cancer [ 31 ], and prostate cancer [ 40 ]. Of the publications, 12 had quality scores higher than nine, and 10 had quality scores of no more than nine.…”

Section: Resultsmentioning

confidence: 99%

XPGgene rs751402 C>T polymorphism and cancer risk: Evidence from 22 publications

et al. 2017

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The Xeroderma pigmentosum group G (XPG) gene promotes recognition and excision of damaged DNA during the DNA repair process. We conducted a comprehensive search of the MEDLINE, EMBASE, and Chinese Biomedical databases for publications evaluating the association XPG gene rs751402 C>T polymorphism and overall cancer risk. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were adopted to assess the strength of the association. A total of 22 publications encompassing 10538 cases and 10511 control subjects were included in the final meta-analysis. We found the polymorphism to be associated with increased cancer risk (TT vs. CC: OR = 1.18, 95% CI = 1.01–1.38, P = 0.040; CT vs. CC: OR = 1.12, 95% CI = 1.01–1.24, P = 0.040; and CT/TT vs. CC: OR = 1.12, 95% CI = 1.002–1.26, P = 0.045). Stratification by cancer type indicated that this polymorphism may increase the risk of gastric cancer and hepatocellular carcinoma, which was further confirmed by a false-positive report probability analysis. Genotype-based mRNA expression provides further evidence that this polymorphism is associated with altered XPG mRNA expression. This meta-analysis suggests XPG gene rs751402 C>T polymorphism correlates with overall cancer risk, especially for gastric cancer and hepatocellular carcinoma.

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XPG Gene Polymorphisms and the Risk of Gastric Cardia Adenocarcinoma

Abstract: Our findings indicate that the rs751402 C/T SNP has potential as a predictive marker for the risk of GCA and that carriers of the T/T genotype should receive periodic upper gastrointestinal fiber tests to facilitate the early detection and early treatment of GCA.

Cited by 10 publications

References 33 publications

XPGgene polymorphisms and cancer susceptibility: evidence from 47 studies

XPGgene polymorphisms and cancer susceptibility: evidence from 47 studies

The association between XPG polymorphisms and cancer susceptibility

XPGgene rs751402 C>T polymorphism and cancer risk: Evidence from 22 publications

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