XRCC1polymorphism and lung cancer risk

No association betweenXRCC1polymorphisms and survival in non-small-cell lung cancer patients treated with platinum-based chemotherapy

“…However, the previous studies on these nonsynonymous SNPs were mostly focused on their correlation with cancer susceptibility showing that these polymorphisms in XRCC1 altered risks of certain types of cancer including lung cancer. [12][13][14] Our previous findings also suggested that these polymorphisms might have impact in the development of esophageal cancer. 15 In view of the Arg399Gln (rs25487), were associated with survival of advanced NSCLC patients treated with platinum-based chemotherapy.…”

“…11 The choice of the three polymorphisms in the current study was driven by their functional significance and their association with increased risk of various cancer development by prior evaluation in numerous risk-association studies. 12,13,32,33 According to the hypothesis that DNA repair capacity may act as double-edged sword in lung cancer development and therapy, the polymorphisms that decrease DNA repair capacity are expected to correlate to increased risk of developing cancer but improved survival in patients treated with platinum agents. Several studies have investigated the associations between XRCC1 Arg399Gln polymorphisms and survival in patients with NSCLC, [18][19][20][21]34,35 whereas only one has been conducted regarding to the association of Arg194Trp and Arg280His polymorphisms with outcome of NSCLC with radiotherapy.…”

DNA Repair Capacity-Related to Genetic Polymorphisms of DNA Repair Genes and Aflatoxin B1-Related Hepatocellular Carcinoma Among Chinese Population

“…Three single nucleotide polymorphisms in the coding region of XRCC1 gene that lead to amino acid substitution have been described and investigated (12). Of these polymorphisms, the codon 399 polymorphism is of special concern, because this polymorphism resides in functionally significant regions (BECT II) and may be related to decreasing DNA repair capacity, increasing genes mutation, and running-up risk of cancers (12,(107)(108)(109)(110)(111)(112)(113)(114). In AFB1-exposure areas from China, a total of six molecular epidemiological studies were found in PubMed database, Wangfang Database, and Weipu database (61,62,(115)(116)(117)(118).…”

The Codon 399 Arg/Gln XRCC1 Polymorphism is Associated with Lung Cancer in Indians

“…Human XRCC1 is located on chromosome 19q13.2-13.3 (Thompson et al, 1989;Mohrenweiser and Jones 1998) and two known polymorphisms at codon 280 (exon9, base 27466 G to A, Arg to His) and codon 399 (exon10, base 28152 G to A, Arg to Gln) leads to amino acid substitution has been discussed by Shen et al (1998) 5276 and Schneider et al (2008).…”