Zingiber officinale: A Potential Plant against Rheumatoid Arthritis

Abstract

Rheumatoid arthritis (RA) is an autoimmune disease particularly affecting elderly people which leads to massive bone destruction with consequent inflammation, pain, and debility. Allopathic medicine can provide only symptomatic relief. However, Zingiber officinale is a plant belonging to the Zingiberaceae family, which has traditionally been used for treatment of RA in alternative medicines of many countries. Many of the phytochemical constituents of the rhizomes of this plant have therapeutic benefits including amelioration of RA. This review attempts to list those phytochemical constituents with their reported mechanisms of action. It is concluded that these phytochemicals can form the basis of discovery of new drugs, which not only can provide symptomatic relief but also may provide total relief from RA by stopping RA-induced bone destruction. As the development of RA is a complex process, further research should be continued towards elucidating the molecular details leading to RA and drugs that can stop or reverse these processes by phytoconstituents of ginger.

99Tc-MDP treatment for the therapy of rheumatoid arthritis, choroidal neovascularisation and Graves' ophthalmopathy

“…Although it can affect numerous tissues and organs, it primarily involves flexible joints (6) resulting in synovitis, pannus formation (7) and massive bone destruction with consequent inflammation, pain and disability (8), associated with higher mortality as compared to the general population (9,10 Similarly, Gong et al (13) reported that 0.01 µg/ml 99 Tc-MDP significantly inhibited RANKL-induced osteoclastogenesis with no cytotoxicity, and significantly abolished the appearance of multinucleated osteoclasts, inhibited the expression of the transcription factors c-Fos, nuclear factor of activated T cells and inflammatory factors, such as IL-6, TNF-α and IL-1β. Thus, 99 Tc-MDP has anti-osteoclastogenic activity on RANKL-induced osteoclast formation.…”

Phytotherapie in Vietnam

“…Kiện Khớp Tiêu Thống (KKTT) ist eine Teemischung, die oral gegen Beschwerden bei Arthritis und Arthrose eingesetzt wird. KKTT enthält Rhizoma Drynariae (Drynaria fortunei (Kunze) (antiosteoporotisch) [16], Cortex Acanthopanicis (Acanthopanax gracilistylus) (antiosteoporotisch) [17], Concha Ostreae (Austernschalen), Rhizoma Zingiberis (Zingiber officinale) (antiinflammatorisch) [18], Herba Siegesbeckiae orientalis (Siegesbeckia orientalis L.) (antiinflammatorisch) [19], Rhizoma Cibotii (Cibotium barometz (L.) J. Sm.)…”

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“…[55] The antiarthritic activity of shagoal is due to suppression of IL-1 β, IL-6, TNF-α, and INF-γ. [56,57] The efficacy and tolerability of ginger in management of arthritis has been tested in patients with knee joint pain. Ginger powder exhibited significant reduction in arthritis index and visual analog scale scores and it is attributed to reduced production of NO and CRP.…”