<i>α</i>‐Glucosidase Inhibitors from the Stems of <i>Embelia ribes</i>

Dang, Phu Hoang; Nguyen, Hai Xuan; Nguyen, Nhan Trung; Le, Hanh Ngoc Thi; Nguyen, Mai Thanh

doi:10.1002/ptr.5175

Cited by 40 publications

(16 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The methylene proton at δ H 2.67 (H-4) showed HMBC correlations with the δ C 78.4 (C-2), 65.2 (C-3), 156.2 (8a), and 99.0 (5a) in agreement with the substitution pattern in ring C. The HMBC correlations between the proton at δ H 6.88 (H-6′) and δ H 6.67 (H-5′) with that of δ C 78.4 (C-2) and two oxygenated sp 2 vicinal quaternary carbons at δ C 144.6 (C-4′) and 144.7 (C-3′) further support the ABX multiplicity pattern of ring B confirming the exact location of the two hydroxyl groups to be at C-3′ and 4′ positions. Thus, based on the above spectral data the structure of the compound was found to be 3,5,7,3′,4′-pentahydroxyflavan ( 1 ) similar to the previously identified compound epicatechin ( 1 ) with various pharmacological activity [ 11 , 12 ].…”

Section: Resultssupporting

confidence: 68%

Antibacterial Activity of Two Flavans from the Stem Bark of Embelia schimperi

Guyasa

Melaku

Endale

2018

Advances in Pharmacological Sciences

View full text Add to dashboard Cite

Embelia schemperi Vatke is one of the medicinal plants used traditionally for treatment of intestinal tape worm, dysmenorrheal, bacterial, and fungal infections. Phytochemical screening test of the dichloromethane/methanol (1 : 1) and methanol extracts revealed the presence of phenols, alkaloids, tannins, and flavonoids whereas terpenoids, glycoside, and phytosterols were absent. Silica gel column chromatographic separation of the methanol extract afforded 3,5,7,3′,4′-pentahydroxyflavan, named epicatechin (1), along with a close flavan derivative (2). Structures of the compounds were elucidated by spectroscopic techniques (1D and 2D NMR, FTIR, and UV-Vis). The crude extracts and isolated compounds were screened for in vitro antibacterial activity against strains of Klebsiella pneumoniae, Escherichia coli, Cryptococcus neoformans, Shigella dysentriae, and Staphylococcus aureus. Epicatechin (1) exhibited comparable antibacterial activity against S. aureus and E. coli (15 and 12 mm zone of inhibition, resp.) to that of the control antibiotic gentamicin, with zone of inhibition of 15 and 12 mm, respectively, at a concentration of 20 µg/mL.

show abstract

Section: Resultssupporting

confidence: 68%

Antibacterial Activity of Two Flavans from the Stem Bark of Embelia schimperi

Guyasa

Melaku

Endale

2018

Advances in Pharmacological Sciences

View full text Add to dashboard Cite

show abstract

“…Compared with those on ingredients 11 , 16 , and 18 , few findings on the antioxidant and anti-inflammatory effects of MPP have been published. It has been reported that MPP displayed inhibitions against 5-lipoxygenase [ 41 ], α -glucosidase [ 42 ], and Mycobacterium tuberculosis H37Rv in vitro [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Ingredients from Litsea garrettii as Potential Preventive Agents against Oxidative Insult and Inflammatory Response

Sun

et al. 2018

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Oxidative stress and inflammation undoubtedly contribute to the pathogenesis of many human diseases. The nuclear transcription factor erythroid 2-related factor (Nrf2) and the nuclear factor κB (NF-κB) play central roles in regulation of oxidative stress and inflammation and thus are targets for developing agents against oxidative stress- and inflammation-related diseases. Our previous study indicated that the EtOH extract of Litsea garrettii protected human bronchial epithelial cells against oxidative insult via the activation of Nrf2. In the present study, a systemic phytochemical investigation of L. garrettii led to the isolation of twenty-one chemical ingredients, which were further evaluated for their inhibitions on oxidative stress and inflammation using NAD(P)H:quinone reductase (QR) assay and nitric oxide (NO) production assay. Of these ingredients, 3-methoxy-5-pentyl-phenol (MPP, 5) was identified as an Nrf2 activator and an NF-κB inhibitor. Further studies demonstrated the following: (i) MPP upregulated the protein levels of Nrf2, NAD(P)H:quinone oxidoreductase 1 (NQO1), and glutamate-cysteine ligase regulatory subunit (GCLM); enhanced the nuclear translocation and stabilization of Nrf2; and inhibited arsenic [As(III)]-induced oxidative insult in normal human lung epithelial Beas-2B cells. And (ii) MPP suppressed the nuclear translocation of NF-κB p65 subunit; inhibited the lipopolysaccharide- (LPS-) stimulated increases of NF-κB p65 subunit, COX-2, iNOS, TNF-α, and IL-1β; and blocked the LPS-induced biodegrade of IκB-α in RAW 264.7 murine macrophages. Taken together, MPP displayed potential preventive effects against inflammation- and oxidative stress-related diseases.

show abstract

“…17 Alkenylresorcinol, embeliphenol-A has been isolated from ethyl acetate extract of the stems of Embelia Ribes that possess significant α-glucosidase inhibitory activity in a concentrationdependent manner. 18 Embelin, isolated from Embelia Ribes fruits, regulated insulin mediated glucose uptake in epididymal adipose tissue through translocation and activation of GLUT4. 19 Histopathological observations in streptozotocin induced diabetic rats have shown the rejuvenation of β-cells destroyed by following embelin treatment, which indicates the insulinmimicking effect of embelin by regenerating insulin producing cells.…”

Section: Effects Of Embelia Ribes On Elevated Blood Sugarmentioning

confidence: 99%

A Review on Therapeutic Use of Vidanga (Embelia Ribes) for Pathological Consequences Associated With Obesity as Per Ayurvedic Classics

Kundu¹,

Hazera²,

Mandal³

et al. 2019

Int. Res. J. Pharm.

View full text Add to dashboard Cite

Atisthaulya is one of the oldest documented metabolic disturbance in Ayurveda associated with obesity. In Ayurvedic literature, Ati-sthaulya has been described not as obese state only rather than a clustering of pathological events induced by obesity. The concept of Atisthoulya bear a resemblance with metabolic syndrome (MetS). Vidanga (Embelia Ribes) is one of the important herb that has been described in Charak Samhita to treat Atisthoulya. This reviews aims at providing scientific evidences behind such use of Vidanga (Embelia Ribes).

show abstract

α‐Glucosidase Inhibitors from the Stems of Embelia ribes

Cited by 40 publications

References 16 publications

Antibacterial Activity of Two Flavans from the Stem Bark of Embelia schimperi

Antibacterial Activity of Two Flavans from the Stem Bark of Embelia schimperi

Ingredients from Litsea garrettii as Potential Preventive Agents against Oxidative Insult and Inflammatory Response

A Review on Therapeutic Use of Vidanga (Embelia Ribes) for Pathological Consequences Associated With Obesity as Per Ayurvedic Classics

Contact Info

Product

Resources

About