Iatrogenic Cushing’S Syndrome as a Consequence of Nasal Use of Betamethasone Spray During Pregnancy

Scutelnicu, Ana Maria; Panaitescu, Anca Maria; Ciobanu, Anca Marina; Gică, Nicolae; Botezatu, Radu; Peltecu, Gheorghe; Gheorghiu, Monica Livia

doi:10.4183/aeb.2020.511

Cited by 2 publications

(1 citation statement)

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“…In practice however, studies have repeatedly shown that FS are not efficacious in preventing CHB or evolution to complete AV block [21,22]. Moreover, their use is associated with important adverse effects both for the woman and the baby including impaired kidney function with reduced amniotic fluid volume, impaired thyroid function in the fetus, low birth weight, maternal glucose intolerance, anxiety [23,24] and possible negative effects on brain development of the child [24]. In our case, obviously, we cannot tell whether FS added from the moment we discovered the recurrent CHB had any effect.…”

Section: Discussionmentioning

confidence: 99%

Recurrent Congenital Heart Block Due to Maternal Anti-Ro Antibodies: Successful Prevention of Poor Pregnancy Outcome with Hydroxychloroquine and Added Dexamethasone

et al. 2022

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Autoimmune Congenital Heart Block (CHB) is an immune-mediated disease caused by transplacental passage of maternal circulating anti-Ro/SSA and anti-La/SSB antibodies which can bind to fetal cardiac tissue, damaging conduction tissues by inflammation and fibrosis. Approximately 2% of pregnancies with positive anti-Ro antibodies will be complicated by fetal atrioventricular block and the risk of recurrence in subsequent pregnancies is 10 times higher. We report a case of a clinically asymptomatic patient diagnosed with anti-Ro antibodies who had two pregnancies complicated by CHB with different outcomes. Despite preventive treatment with hydroxychloroquine (HCQ) from 6 weeks of pregnancy onward, the fetus developed second to third degree CHB. Dexamethasone was added. The pregnancy evolved to near-term with persistent intermittent CHB. It is not clear how pregnancies with recurrent fetal CHB despite prophylaxis with HCQ should be managed and there is a need for controlled studies to answer the remaining questions in relation to this subject.

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Section: Discussionmentioning

confidence: 99%