Iatrogenic metastasis of a benign meningioma to the periosteum at the site of previous craniotomy: a case report

Abstract

Metastasis formation after resection of meningiomas is a rare event, predominantly occurring with malignant phenotypes. As far as we know, the presented case is the first report in the literature of iatrogenic seeding of a benign meningioma to the scalp following surgery. A 37-year-old woman was admitted because of a relapsing meningioma in the frontal lobe. In 1997, she had undergone complete excision of an atypical meningioma in same location. At follow-up, three new masses were found: a bifrontal meningioma on the edge of the falx, a smaller one in the falx just under the saggital sinus and a small mass, believed to be ectopic, in the periosteum at the site of the previous craniotomy. Surgical therapy was indicated. Histologically, the ectopic tumor was an atypical meningioma, similar to the one excised 10 years previously, with no relation to the other two intracranial masses. Because of the histological similarity and the location in the old craniotomy, the ectopic tumor was believed to have developed from an implantation metastasis as a consequence of the first surgery. The authors suggest that strict adherence to oncological principles should be applied in the case of benign neoplasms in order to prevent contamination of wounds with tumor cells and potential recurrence.

Metastasis of an occult pulmonary carcinoma into meningioma: a case report

“…Surgical excision is the principal form of treatment of patients with a history of extracranial cancer although stereotactic radiosurgery is becoming a desirable alternative therapeutic option, especially in eloquent areas of the brain [ 13 – 15 ]. A concomitant solitary intracranial mass must be preceded by radiographical determination of the extent of the primary lesion and possible metastatic deposits [ 13 ]. In order to diagnose these tumours, various imaging modalities may be employed, including computer tomography (CT) and magnetic resonance imaging (MRI) [ 8 ].…”

Brain meningioma invading and destructing the skull bone: replacement of the missing bone in vivo

“…It was suggested that strict adherence to oncological principles should be applied also in the case of benign neoplasms in order to prevent contamination of wounds with tumour cells and potential recurrence 20. Often, a radical resection may be attained with low morbidity in operated patients, providing a significantly better long-term clinical outcome 10.…”

A menigothelial meningioma (WHO grade I) with malignant progression and cutaneous, pulmonary and bone metastases: a case report

“…Yang et al [2] described that 1.8% of 1098 examined patients showed malignant progression. Extracranial metastases are very rare and often spread to the lungs and the scalp [5][6][7][8]. We present the case report of a 50-year-old man suff ering from a frontal meningothelial meningioma (WHO grade I) with malignant progression and metastases in the lung, scalp, skin and bone.…”