Ibogaine in Acute Opioid Withdrawal: An Open Label Case Series

Alper, Kenneth; Lotsof, Howard S.; Frenken, Geerte M. N.; Luciano, Daniel; J, Bastiaans

doi:10.1111/j.1749-6632.2000.tb06687.x

Cited by 20 publications

(22 citation statements)

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“…In another study, it failed to attenuate morphine‐induced CPP in mice (Luxton et al ., ). In a study on heroin‐dependent humans, drug‐seeking behavior and withdrawal complaints were diminished in 76% (25) of the subjects after a single‐dose treatment with ibogaine (Alper et al ., ). There are many studies in the literature about the effects of iboga alkaloids, some with conflicting results (Popik et al ., ).…”

Section: Plant Bioactive Componentsmentioning

confidence: 97%

Phytotherapy of Opioid Dependence and Withdrawal Syndrome: A Review

Tabatabai

Dashti

Doosti

et al. 2013

Phytotherapy Research

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Development of tolerance and dependence is a major problem associated with opioid treatment. Withdrawal syndrome is common between medical and illicit users of these agents. Phytomedicine has shown promise in the treatment of this complicated psychosomatic condition. In this study, the effects of plant extracts and active components on morphine dependence and withdrawal syndrome are discussed. Proper keywords were used to search through PubMed, Google Scholar, and SciVerse, as well as two local scientific databases, www.iranmedex.com and www.SID.com. All relevant results (original articles, meeting abstracts, patents, etc.) published from 2000 to 2013 were chosen for final review. A total of 35 plant species were studied on this subject. Plants from Lamiaceae, Ranunculaceae, and Apiaceae families were especially effective. A few studies were carried out on human subjects and the rest in animal models. Opioid dependence and withdrawal syndrome remain an intimidating challenge. Nonetheless, plants and their derivatives are suitable sources for their treatment. Although there are several plants shown to be effective in animal models, few clinical studies are available.

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Section: Plant Bioactive Componentsmentioning

confidence: 97%

Phytotherapy of Opioid Dependence and Withdrawal Syndrome: A Review

Tabatabai

Dashti

Doosti

et al. 2013

Phytotherapy Research

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“…The forms of CHM included in this meta-analysis included both SFDAapproved and non-approved herbs. Traditional herbal medicine is also being systematically tested for addiction treatment in India, Thailand, Iran, and elsewhere (Alper et al 1999(Alper et al , 2000Akhondzadeh et al 2001).…”

Section: Discussionmentioning

confidence: 99%

A Meta-Analysis of Chinese Herbal Medicine in Treatment of Managed Withdrawal from Heroin

et al. 2008

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Chinese herbal medicine has shown promise for heroin detoxification. This review extends a prior meta-analysis of Chinese herbal medicine for heroin detoxification, with particular attention to the time course of symptoms. Both English and Chinese databases were searched for randomized trials comparing Chinese herbal medicine to either alpha2-adrenergic agonists or opioid agonists for heroin detoxification. The methodological quality of each study was assessed with Jadad's scale (1-2 = low; 3-5 = high). Meta-analysis was performed with fixed- or random-effect models in RevMan software; outcome measures assessed were withdrawal-symptoms score, anxiety, and adverse effects of treatment. Twenty-one studies (2,949 participants) were included. For withdrawal-symptoms score relieving during the 10-day observation, Chinese herbal medicine was superior to alpha2-adrenergic agonists in relieving opioid-withdrawal symptoms during 4-10 days (except D8) and no difference was found within the first 3 days. Compared with opioid agonists, Chinese herbal medicine was inferior during the first 3 days, but the difference became non-significant during days 4-9. Chinese herbal medicine has better effect on anxiety relieving at late stage of intervention than alpha2-adrenergic agonists, and no difference with opioid agonists. The incidence of some adverse effects (fatigue, dizziness) was significantly lower for Chinese herbal medicine than for alpha2-adrenergic agonists (sufficient data for comparison with opioid agonists were not available). Findings were robust to file-drawer effects. Our meta-analysis suggests that Chinese herbal medicine is an effective and safety treatment for heroin detoxification. And more work is needed to determine the specific effects of specific forms of Chinese herbal medicine.

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“…These medications can provide an alternative for individuals who may not be interested in attending public treatment programs provided by the government, or who have not been successful in public treatment programs. These medications include ibogaine, baclofen, and modafinil singularly, or the combination of clonidine, lorazepam, trazodone and a stimulant in combination [40][41][42][43]. These medications have shown efficacy only in clinical trials.…”

Section: Additional Pharmacotherapies and Treatment Paradigmsmentioning

confidence: 99%

International Expansion of the Use of Pharmacotherapies for the Treatment of Opioid Dependence

Kresina¹

2012

Clinic Experiment Pharmacol

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Until recently, the global availability and consumption of opioid agonists and psychotropic medications have been below the levels needed for research to demonstrate local efficacy and to develop local evidence-based best medical practices. In addition, the global availability and use of opioid agonists and psychotropic medications have not been sufficient to implement the well documented efficacy shown for the treatment of opioid dependence that has been developed by research over the last 40 years. This strong research base has resulted in the development of evidencebased medical practices, such as Medication Assisted Treatment (MAT) for opioid dependence. The recognition of MAT as an effective medical treatment for opioid abuse and dependence has resulted in a substantial global increase in the medical use of opioid agonists and psychotropic medications to address opioid dependence. This increase is particularly evident in the initiation of new MAT programs in regions of Europe, North America, Africa, Asia and Oceania. While in other regions of the world, the medical use of opioid agonists and psychotropic medications have not substantially increased, the implementation of MAT programs have begun as part of the global effort to reduce HIV/AIDS. These HIV prevention programs have utilized MAT as an element of programs that target injection drug users to reduce their risk of both acquiring and transmitting HIV infection. Thus, this article documents the recent international expansion of the use of MAT for opioid dependence as a result of efforts to increase access and availability of evidence based treatments for opioid dependence as well as efforts to reduce the spread of infectious diseases, such as HIV/AIDS.

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Ibogaine in Acute Opioid Withdrawal: An Open Label Case Series

Cited by 20 publications

References 0 publications

Phytotherapy of Opioid Dependence and Withdrawal Syndrome: A Review

Phytotherapy of Opioid Dependence and Withdrawal Syndrome: A Review

A Meta-Analysis of Chinese Herbal Medicine in Treatment of Managed Withdrawal from Heroin

International Expansion of the Use of Pharmacotherapies for the Treatment of Opioid Dependence

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