IBSP, a potential recurrence biomarker, promotes the progression of colorectal cancer via Fyn/β‐catenin signaling pathway

Yan, Cheng; Qin, Ying; Dai, Mengmeng; Liu, Liping; Ni, Yicheng; Sun, Qiao; Li, Lulu; Zhou, Yaoyao; Qiu, Cheng; Jiang, Yuyang

doi:10.1002/cam4.3959

Cited by 14 publications

(10 citation statements)

References 42 publications

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“…Ampelopsins A and C induce cell metastasis by downregulating FYN expression in breast cancer cells [ 129 ]. IBSP promotes the growth and invasiveness of colorectal cancer (CRC) by a potential mechanism of activating the FYN/β-catenin signaling pathway [ 130 ]. FYN expression is elevated in melanoma cells, and knockdown of FYN significantly inhibits the proliferation and migration of melanoma cells by downregulating CD147 phosphorylation [ 92 ].…”

Section: The Downstream Substrates Regulated By Fyn In Tumors and Its...mentioning

confidence: 99%

FYN: emerging biological roles and potential therapeutic targets in cancer

Peng

2023

J Transl Med

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Src family protein kinases (SFKs) play a key role in cell adhesion, invasion, proliferation, survival, apoptosis, and angiogenesis during tumor development. In humans, SFKs consists of eight family members with similar structure and function. There is a high level of overexpression or hyperactivity of SFKs in tumor, and they play an important role in multiple signaling pathways involved in tumorigenesis. FYN is a member of the SFKs that regulate normal cellular processes. Additionally, FYN is highly expressed in many cancers and promotes cancer growth and metastasis through diverse biological functions such as cell growth, apoptosis, and motility migration, as well as the development of drug resistance in many tumors. Moreover, FYN is involved in the regulation of multiple cancer-related signaling pathways, including interactions with ERK, COX-2, STAT5, MET and AKT. FYN is therefore an attractive therapeutic target for various tumor types, and suppressing FYN can improve the prognosis and prolong the life of patients. The purpose of this review is to provide an overview of FYN’s structure, expression, upstream regulators, downstream substrate molecules, and biological functions in tumors.

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Section: The Downstream Substrates Regulated By Fyn In Tumors and Its...mentioning

confidence: 99%

FYN: emerging biological roles and potential therapeutic targets in cancer

Peng

2023

J Transl Med

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“…In a number of studies [ 23 , 26 ], Wnt signaling has been linked to GBM development, invasion, and treatment resistance. IBSP is a focal adhesion protein that aids in cell adhesion and migration on the cell surface [ 37 ]. In gliomas, the clinical importance of IBSP is unclear.…”

Section: Discussionmentioning

confidence: 99%

“…According to studies, IBSP can form a trimolecular complex with integrins and MMP2, speeding up local matrix breakdown and cancer cell invasion [ 11 ]. As a result, from an indirect consideration of molecular function, DKK1 and IBSP may be involved in degrading the extracellular matrix, thereby providing space for GPTBE [ 37 , 38 ]. All these differentially expressed genes were identified in previous GPTBE research, demonstrating that GPTBE is caused by multifactorial, multidimensional changes in the tumor microenvironment.…”

Section: Discussionmentioning

confidence: 99%

Identifying the Hub Genes of Glioma Peritumoral Brain Edema Using Bioinformatical Methods

Peng

Wang

et al. 2022

Brain Sciences

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Glioma peritumoral brain edema (GPTBE) is a frequent complication in patients with glioma. The severity of peritumoral edema endangers patients’ life and prognosis. However, there are still questions concerning the process of GPTBE formation and evolution. In this study, the patients were split into two groups based on edema scoring findings in the cancer imaging archive (TCIA) comprising 186 TCGA-LGG patients. Using mRNA sequencing data, differential gene (DEG) expression analysis was performed, comparing the two groups to find the key genes affecting GPTBE. A functional enrichment analysis of differentially expressed genes was performed. Then, a protein–protein interaction (PPI) network was established, and important genes were screened. Gene set variation analysis (GSVA) scores were calculated for major gene sets and comparatively correlated with immune cell infiltration. Overall survival (OS) was analyzed using the Kaplan–Meier curve. A total of 59 DEGs were found, with 10 of them appearing as important genes. DEGs were shown to be closely linked to inflammatory reactions. According to the network score, IL10 was in the middle of the network. The presence of the IL10 protein in glioma tissues was verified using the human protein atlas (HPA). Furthermore, the gene sets’ GSVA scores were favorably linked with immune infiltration, particularly, with macrophages. The high-edema group had higher GSVA scores than the low-edema group. Finally, Kaplan–Meier analysis revealed no differences in OS between the two groups, and eight genes were found to be related to prognosis, whereas two genes were not. GPTBE is linked to the expression of inflammatory genes.

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“…This brief synopsis, demonstrating the varied mechanistic aspects of RGD-integrin mediated cell behavior, sets the stage for the discussion below, to consider how specific proteins and linked integrins, may influence metabolic activity, both locally and at distant sites. Below we consider six RGD containing proteins and their known and proposed functions in modulating metabolic activity, summarized in Table 1 (8,9,14,19).…”

Section: Known and Proposed Functions Of The Rgd Region In Proteinsmentioning

confidence: 99%

Does the RGD region of certain proteins affect metabolic activity?

et al. 2022

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A better understanding of the role of mineralized tissues and their associated factors in governing whole-body metabolism should be of value toward informing clinical strategies to treat mineralized tissue and metabolic disorders, such as diabetes and obesity. This perspective provides evidence suggesting a role for the arginine-glycine-aspartic acid (RGD) region, a sequence identified in several proteins secreted by bone cells, as well as other cells, in modulating systemic metabolic activity. We focus on (a) two of the SIBLING (small integrin-binding ligand, N-linked glycoprotein) family genes/proteins, bone sialoprotein (BSP) and osteopontin (OPN), (b) insulin-like growth factor-binding protein-1 & 2 (IGFBP-1, IGFBP-2) and (c) developmental endothelial locus 1 (DEL1) and milk fat globule–EGF factor-8 (MFG-E8). In addition, for our readers to appreciate the mounting evidence that a multitude of bone secreted factors affect the activity of other tissues, we provide a brief overview of other proteins, to include fibroblast growth factor 23 (FGF23), phosphatase orphan 1 (PHOSPHO1), osteocalcin (OCN/BGLAP), tissue non-specific alkaline phosphatase (TNAP) and acidic serine aspartic-rich MEPE-associated motif (ASARM), along with known/suggested functions of these factors in influencing energy metabolism.

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IBSP, a potential recurrence biomarker, promotes the progression of colorectal cancer via Fyn/β‐catenin signaling pathway

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 14 publications

References 42 publications

FYN: emerging biological roles and potential therapeutic targets in cancer

FYN: emerging biological roles and potential therapeutic targets in cancer

Identifying the Hub Genes of Glioma Peritumoral Brain Edema Using Bioinformatical Methods

Does the RGD region of certain proteins affect metabolic activity?

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