Ibuprofen

GLC Determination of Ibuprofen [dl-2-(p-Isobutylphenyl)propionic Acid] Enantiomers in Biological Specimens

“…The extensive toxicological and biochemical studies (3-5) in animals and humans (6) have been comprehensively reviewed (7).…”

Preparation of Controlled-Release Microspheres of Ibuprofen With Acrylic Polymers by a Novel Quasi-Emulsion Solvent Diffusion Method

“…In the present process, ibuprofen was used as a model drug because i t is widely prescribed as an anti-inflammatory, antipyretic, a n d analgesic drug, a n d since well-controlled release dosage forms have been designed to reduce its side action (i.e., ulceration of the GI tract7) a n d to improve the bioavailability. 8 The factors determining the size and the d r u g release rate of the resultant microspheres were investigated. A quasi-emulsion solvent diffusion model w a s proposed t o explain the mechanism of formation of the microsphere.…”

Multicenter study of the effectiveness of postoperative pain relief in Ukraine using paracetаmol in surgical hospitals – “ROZUM”

“…Ще через 10 років стало очевидним, що існує по крайній мірі дві ізоформи ЦОГ, відповідно названі ЦОГ-1 та ЦОГ-2 [8]. Більшість відомих на сьогодні НПЗП одночасно блокують ЦОГ-1 та ЦОГ-2 [9]. Існує точка зору, яка підтримує наявність селективності препаратів у відношенні цих ферментів.…”