Ibuprofen at environmentally relevant concentrations alters embryonic development, induces teratogenesis and oxidative stress in Cyprinus carpio

Gutiérrez-Noya, Verónica Margarita; Gómez-Oliván, Leobardo Manuel; Ramírez-Montero, María del Carmen; Islas-Flores, Hariz; Galár-Martínez, Marcela; Dublán‐García, Octavio; Romero, Rubı́

doi:10.1016/j.scitotenv.2019.136327

Cited by 41 publications

(15 citation statements)

References 71 publications

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“…For example, salicylic acid was recently found to be present in all the water samples (hospital effluent, wastewater treatment plant influent and effluent, and seawater) in several countries [8,[11][12][13][14][15][16]. Ibuprofen was also detected in the same type of water samples and in a river grab sample [12][13][14][15]17] and has been highlighted to be the most consumed medicine all over the world [18,19]. Therefore, there is general consensus about the fact that WWTPs are potential sources of pharmaceuticals, including these NSAIDs, for the aquatic environment [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Green Microalgae Scenedesmus Obliquus Utilization for the Adsorptive Removal of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) from Water Samples

Silva

Coimbra

Escapa

et al. 2020

IJERPH

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In view of the valorisation of the green microalga Scenedesmus obliquus biomass, it was used for the biosorption of two nonsteroidal anti-inflammatory drugs, namely salicylic acid and ibuprofen, from water. Microalgae biomass was characterized, namely by the determination of the point of zero charge (pHPZC), by Fourier transform infrared (FT-IR) analysis, simultaneous thermal analysis (STA) and scanning electron microscopy with energy dispersive spectroscopy (SEM/EDS). Kinetic and equilibrium batch experiments were carried out and results were found to fit the pseudo-second order equation and the Langmuir isotherm model, respectively. The Langmuir maximum capacity determined for salicylic acid (63 mg g−1) was larger than for ibuprofen (12 mg g−1), which was also verified for a commercial activated carbon used as reference (with capacities of 250 and 147 mg g−1, respectively). For both pharmaceuticals, the determination of thermodynamic parameters allowed us to infer that adsorption onto microalgae biomass was spontaneous, favourable and exothermic. Furthermore, based on the biomass characterization after adsorption and energy associated with the process, it was deduced that the removal of salicylic acid and ibuprofen by Scenedesmus obliquus biomass occurred by physical interaction.

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Section: Introductionmentioning

confidence: 99%

Green Microalgae Scenedesmus Obliquus Utilization for the Adsorptive Removal of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) from Water Samples

Silva

Coimbra

Escapa

et al. 2020

IJERPH

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“…Synthetic chemicals, which are components in many of today's essential products, such as pharmaceuticals, food and cosmetics as well as industrial and household chemicals, are produced and consumed in significant amounts. For example, the worldwide consumption of the non‐steroidal antirheumatic Diclofenac (DCF) was estimated to be greater than 1400 tons per year (Acuña et al, 2015), while the production of Ibuprofen (IBP) used to treat fever, pain, and inflammation reaches millions of tons every year (Gutiérrez‐Noya et al, 2020). After their application, organic micropollutants can enter the environment in various ways like industry, agriculture, households (Burkhardt‐Holm, 2011), or stormwater runoff (Markiewicz et al, 2020), with Water Resource Recovery Facilities (WRRF) being one of the most important continuous input paths into water bodies (Bartelt‐Hunt et al, 2009; Clara et al, 2005; da Silva et al, 2011; Göbel et al, 2007; Luo et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Fate of selected organic micropollutants during anaerobic sludge digestion

Hammer

Palmowski

2021

Water Environment Research

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Organic micropollutants are incompletely removed from wastewater in Water Resource Recovery Facilities using conventional methods and can therefore enter the anaerobic sludge treatment together with primary and secondary sludge. This review compiles literature data on the fate of selected micropollutants (Carbamazepine [CBZ], Diclofenac [DCF], Ibuprofen [IBP], Sulfamethoxazole [SMX], and Triclosan [TCS]) during anaerobic sludge treatment and how the fate is affected by chemical properties, phase distribution and operating conditions. CBZ was found to be persistent to anaerobic degradation in most studies, with some exceptions reporting a degradation efficiency of 60%. Removal efficiencies for DCF, IBP, and TCS varied widely (from no to [very] high removal). For SMX, most studies reported a removal above 80%. A correlation was found between the fate during anaerobic digestion and physicochemical properties (hydrophobicity and molecular structure). Sorption to sludge, affected in some cases by pH changes during digestion, is suggested to reduce bioavailability. IBP and TCS were mainly present in the liquid phase or solid phase, respectively, CBZ and DCF were present in similar proportions in both phases, while statements were contradictory for SMX. Parameters such as temperature and sludge age did not significantly influence the fate of investigated micropollutants during anaerobic digestion. Practitioner points Most studies report no significant removal of CBZ during anaerobic sludge digestion. Removal efficiencies of DCF, IBP, and TCS vary from study to study between no removal and high or very high removal. Considering such heterogeneous removal efficiencies, it is recommended to conduct digestion trials to find out in which range the values will be for a specific sludge. SMX is very highly removed during anaerobic digestion in most studies. Parameters such as temperature and SRT do not significantly influence the fate of the five investigated micropollutants. Hydrophobicity, which has some effect on the liquid/solid phase distribution of micropollutants, and molecular structure influence the removal efficiencies.

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“…Several studies have detected concentrations of ibuprofen in tributaries and e uents of wastewater treatment plants, surface waters, drinking water, sludge, and hospital e uents. Ibuprofen concentrations have been reported around the world in the range of 0.001 and 75.8 µg / L. (Gutiérrez-Noya et al 2020). Ibuprofen may be present in the Magdalena river basin, causing alterations in the cat sh that inhabit these areas and possibly being one of the causes of their decrease in the basin.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of mitochondrial membrane potential and DNA integrity in Catfish Pseudoplatystoma magdaleniatum, when exposed for prolonged times to different concentrations of ibuprofen.

Ríos¹,

Peñuela²

2021

Preprint

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There are few studies to date that determine the effects of ibuprofen on mitochondrial membrane potential (ΔΨM) and DNA integrity in neotropical fish. The objective of this study is to determine if four months’ exposure to ibuprofen in different concentrations (25 and 50 µg/L) produces effects on ΔΨM and alters the integrity of DNA in striped catfish Pseudoplatystoma magdaleniatum. For this study, the fish were placed in tanks with water at constant concentrations of 0 (control), 25, and 50 µg/L of ibuprofen for four months. Subsequently, blood samples were taken for analysis of ΔΨM and DNA integrity, using a flow cytometer LSRFortessa BD Biosciences. After four months of exposure to ibuprofen at different concentrations, the results showed no increase in Low ΔΨM, indicating that there are no alterations in the mitochondrial membrane potential. On the other hand, the percentages of DNA damage were below 0.39, which indicates that there were no alterations in DNA integrity. It is possible that under the conditions in which this study was conducted (ibuprofen levels, exposure time), they are not sufficient to demonstrate the effects caused by this drug. Higher ibuprofen levels and/or longer exposures may be required to determine alteration in ΔΨM and DNA integrity. Flow cytometric analysis for these types of samples is a fast, specific, and reliable technique, compared to traditional methods.

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Ibuprofen at environmentally relevant concentrations alters embryonic development, induces teratogenesis and oxidative stress in Cyprinus carpio

Cited by 41 publications

References 71 publications

Green Microalgae Scenedesmus Obliquus Utilization for the Adsorptive Removal of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) from Water Samples

Green Microalgae Scenedesmus Obliquus Utilization for the Adsorptive Removal of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) from Water Samples

Fate of selected organic micropollutants during anaerobic sludge digestion

Evaluation of mitochondrial membrane potential and DNA integrity in Catfish Pseudoplatystoma magdaleniatum, when exposed for prolonged times to different concentrations of ibuprofen.

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