Ibuprofen nanoparticles-loaded sodium alginate/psyllium seed mucilage beads: evaluation the effect of different parameters on release and swelling rate

Yari, Kasra; Akbari, Iman; Baniasadi, Hossein

doi:10.1007/s00289-022-04186-2

Cited by 5 publications

(3 citation statements)

References 38 publications

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“…This elevated GDL content would lower the pH of the hydrogel, causing the gel network to shrink. [ 31 ] As a result, the swelling ratio of the hydrogel increased at a slower rate. With the decrease in GDL content, CaCO 3 within this system could not fully take part in the cross‐linking reaction, resulting in uneven pores of the gel (Figure S2d,e, Supporting Information).…”

Section: Resultsmentioning

confidence: 99%

“…By calculating the model index using Equation (), the drug release mechanism could be determined. [ 31 ]

\begin{equation}{M}_t/\ {M}_\infty = \ k{t}^n\end{equation}

where t is the drug release time, M t (mg) is the cumulative release at time t , M ∞ (mg) is the maximum cumulative release during release, and k and n are the release constant and release index, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…By calculating the model index using Equation ( 5), the drug release mechanism could be determined. [31] M…”

Section: Release Kinetics Of Ibumentioning

confidence: 99%

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Sodium Alginate Hydrogel Carrier with Calcium Carbonate as Calcium Source for Ibuprofen Release

Lin,

Shi,

Meng

et al. 2023

Macro Chemistry & Physics

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Sodium alginate (SA) hydrogels crosslinked by calcium carbonate (CaCO3) and gluconolactone (GDL) were prepared, and were characterized by X‐ray diffraction (XRD) analysis and Fourier transform infrared (FTIR) spectrometer. The morphologies of the gel were observed with scanning electron microscopy (SEM). The SA hydrogels were used as carrier of the anti‐inflammatory drug IBU. The effects of GDL content, pH value and temperature on IBU release behavior were investigated and associated kinetic analysis was performed. The results showed that the cumulative release of IBU showed a trend of increasing and then decreasing with GDL content increased. The maximum cumulative release was observed when the molar ratio of Ca2+ in CaCO3 to GDL was 0.6. The release behavior of IBU was observed to have been influenced by pH levels, and it exhibited an optimal release trend at a pH value of 7.4. The impact of temperature on the release behavior of IBU was relatively insignificant compared to other factors. The Korsmeyer‐Peppas release kinetic model was well fitted, and suitable to explain the release behavior of IBU from the sodium alginate hydrogel.This article is protected by copyright. All rights reserved

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Section: Resultsmentioning

confidence: 99%

“…By calculating the model index using Equation (), the drug release mechanism could be determined. [ 31 ]