Icariin enhances the healing of rapid palatal expansion induced root resorption in rats

Wang, Feng; Liu, Zhifeng; Su, Lin; Lu, Huai-Xiu; Xu, Juan

doi:10.1016/j.phymed.2012.06.001

Cited by 32 publications

(14 citation statements)

References 14 publications

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“…However, when the mice were treated with icariin for 2 weeks, the expression level of OPG was significantly increased. In addition, icariin suppressed RANKL mRNA expression and decreased protein secretion of RANKL in the presence of Ti particles, which is consistent with the findings of previous studies [21,23]. In addition, icariin treatment decreased the RANKL/OPG ratio and was accompanied by a decreased number and activity of osteoclasts.…”

Section: Discussionsupporting

confidence: 91%

Icariin protects against titanium particle-induced osteolysis and inflammatory response in a mouse calvarial model

et al. 2015

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Section: Discussionsupporting

confidence: 91%

Icariin protects against titanium particle-induced osteolysis and inflammatory response in a mouse calvarial model

et al. 2015

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“…In addition, the area of root resorption was evaluated by painting over the resorbed region of the root and counting the number of involved pixels, as previously described (24). Local root resorption was carefully evaluated on the lingual and labial sides, and the ratio to the area of whole root resorption was calculated.…”

Section: Discussionmentioning

confidence: 99%

Cone-beam computed tomography evaluation of the association of cortical plate proximity and apical root resorption after orthodontic treatment

2016

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“…Previous Studies showed the prevalence of OIIRR in orthodontic treated adolescents to be more than 90%, approximately 15 % exhibiting moderate to severe while 10-20 % of the patients are manifested with severe resorption more than 3 mm (5, 6). Many chemicals/pharmacological agents (fluoride (12), steroidal and nonsteroidal drugs (4,13), calcitonin (14), clodronate (16), Icariin (17), and tetracycline (5,18)) have been tested to prevent or to repair OIIRR. Although most of them were found effective, they are not clinically available due to their possible systemic or side effects on orthodontic tooth movement.…”

Section: Discussionmentioning

confidence: 99%

“…In order to minimize and/or repair the OIIRR; several chemicals and methods have been tested on human and animal study models. Some of these chemicals are fluoride (12), steroidal and nonsteroidal drugs (4,13), calcitonin (14), human growth hormone (15), clodronate (16), Icariin (17), and tetracycline (5,18). Other non-invasive and clinically suitable potential methods to prevent and repair the OIIRR are low-intensity pulsed ultrasound (LIPUS) (19) and low-level laser therapy (LLLT) (1,4,5).…”

Section: Introductionmentioning

confidence: 99%

Effect of Low-Level Laser Therapy on Orthodontic Induced Inflamatory Root Resorption in Rats

Yassin

Shehata

Al-Sawa

et al. 2020

Alexandria Dental Journal

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INTRODUCTION: Low-level laser therapy (LLLT) has been studied in many fields of dentistry due to its reparative and anti-inflammatory effect. Regarding the orthodontic tooth movement, LLLT accelerates tooth movement, reduces the pain, enhances bone remodeling and reduces the orthodontic inflammatory induced root resorption (OIIRR). OBJECTIVES: The aim of the present study was to assess histologically and histomorphometrically the effect of LLLT on OIIRR under heavy orthodontic force magnitude (50 g) in rat model. MATERIALS AND METHODS: Sixteen male Albino rats weighing from (250-300 g) were randomly assigned to two equal groups (8 rats each). Control heavy-force group (CH): the maxillary right first molars were subjected to orthodontic force of 50 g by placement of a coil spring. Laser high-force group (LH): the maxillary right first molars were subjected to orthodontic force of 50 g + LLLT at four points (two buccal and two palatal), 12 seconds per point, with a GaAlAs diode laser source irradiated with the dose of 4.8 J/cm2 (100 mW, 12 s, 0.6 J) on every other day during force application. The rats were sacrificed after 21 days of orthodontic force application. After sacrificing the rats; the maxillae were hemisected and serial sections of the area of maxillary right first molar were obtained and evaluated histologically and histomorphometrically. RESULTS: Root resorption was significantly decreased (p=0.001) in laser group (L) in comparison to the control group (C). In contrast, root resorption was the largest and deepest up to the dentin in the control group. Moreover, odontoclasts were observed especially in the C group indicating still active root resorption activities. In addition, increased blood vasculature and formation of reparative cementum layer covering the resorption lacunae were observed in the Laser group. CONCLUSIONS: LLLT seems promising in preventing or reducing orthodontic root resorption, in addition to accelerating and enhancing the healing and repair of OIIRR.

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Icariin enhances the healing of rapid palatal expansion induced root resorption in rats

Cited by 32 publications

References 14 publications

Icariin protects against titanium particle-induced osteolysis and inflammatory response in a mouse calvarial model

Icariin protects against titanium particle-induced osteolysis and inflammatory response in a mouse calvarial model

Cone-beam computed tomography evaluation of the association of cortical plate proximity and apical root resorption after orthodontic treatment

Effect of Low-Level Laser Therapy on Orthodontic Induced Inflamatory Root Resorption in Rats

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