Icariin exerts an antidepressant effect in an unpredictable chronic mild stress model of depression in rats and is associated with the regulation of hippocampal neuroinflammation

Liu, Baojun; Xu, Changqing; Wu, Xiao; Liu, F; Du, Yong; Sun, Jing; Jiang, Tao; Dong, Jingcheng

doi:10.1016/j.neuroscience.2015.02.053

Cited by 171 publications

(113 citation statements)

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“…However, it is important to note that the correlative nature of these findings precludes definitive conclusions regarding a causal role for the NLRP3 inflammasome in CUS-induced depressive-like behaviors as well as neuroinflammatory processes. In addition, much the same changes have been reported in the hippocampus (Deng et al, 2015a;Liu et al, 2015) and PFC (Deng et al, 2015a). Of note, CUS exposure also was found to increase protein levels of the NLRP3 adaptor protein ASC (Deng et al, 2015a, b;Li et al, 2015).…”

Section: Animal Models Of Depression: Role Of Inflammasomesmentioning

confidence: 56%

Danger Signals and Inflammasomes: Stress-Evoked Sterile Inflammation in Mood Disorders

Fleshner

Frank

Maier

2016

Neuropsychopharmacol

183

125

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Major depressive disorder (MDD) and other mood disorders remain difficult to effectively treat, and innovative interventions and therapeutic targets are needed. Psychological stressors and inappropriate inflammation increase the risk and severity of mood disorders; however, only recently have the importance of sterile inflammatory processes in this effect been revealed. This review will introduce the reader to pathogen vs sterile inflammation, inflammatory receptor-ligand interactions, microbialassociated molecular patterns (MAMPs), pathogen-associated molecular patterns (PAMPs), danger-associated molecular patterns (DAMPs), and the more recent discovery of the role of the inflammasome in peripheral and central nervous system cytokine/chemokine inflammatory responses. The review will focus on current preclinical and clinical evidence that sterile inflammation and inflammasome-dependent signaling may contribute to mood disorders. By understanding these inflammatory signaling processes, new approaches for quieting chronic or inappropriate inflammatory states may be revealed and this could serve as novel pharmacological targets for the treatment of mood disorders.

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Section: Animal Models Of Depression: Role Of Inflammasomesmentioning

confidence: 56%

Danger Signals and Inflammasomes: Stress-Evoked Sterile Inflammation in Mood Disorders

Fleshner

Frank

Maier

2016

Neuropsychopharmacol

183

125

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“…Treatment with 20-40 mg/kg icarine caused decrease in oxidative stress markers and inflammatory mediators in the brain and significantly decreased depression symptoms in mice (Liu et al, 2015).…”

Section: Epimedium Brevicornummentioning

confidence: 91%

“…Evidence indicates that certain inflammatory mediators such as tumor necrosis factor (TNF)-and interleukin (IL)-1 are involved in the development of depression in both affected people and animal models (Liu et al, 2015). In a study, administration with IL-6, IL-1 , TNF-, and lipopolysaccharides caused induction of depression-and anxiety-associated behaviors (Sukoff Rizzo et al, 2012).…”

Section: Biomarkers To Study Depressionmentioning

confidence: 99%

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A review on antidepressant effect of medicinal plants

Rabiei

2017

Bangladesh J Pharmacol

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<p class="Abstract">Depression is a life-threatening, debilitating, and common disease affecting different segments of community. Chemical and synthetic drugs available to treat this disease cause many adverse effects and may lead to complete recovery in only 50% of patients. At the same time, medicinal plants have been reported to exert optimal pharmacological effects in treating depression in different models. In this review, the relevant articles indexed in the reliable databases PubMed, PubMed central, Scopus and Web of Science were review-ed. The review indicated that most medicinal plants exerted antidepressant effects through synaptic regulation of serotonin, noradrenaline, and dopamine, regulating activity of hypothalamic-pituitary-adrenal axis, reinfor-cing anti-oxidant defense system, and decreasing inflammatory mediators. The medicinal plants and their active compounds can relieve depression through different pathways and hence are considered a new source to produce antidepressants.</p>

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“…Previous studies have reported that icariin suppressed inflammatory response by attenuating various intracellular signaling pathways including Nlrp3 and NF‐κB signaling 15, 16. Furthermore, recent work showed that icariin could ameliorate the cisplatin‐induced nephrotoxicity via reducing NF‐κB activation and inflammation 15.…”

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confidence: 99%

Icariin ameliorates IgA nephropathy by inhibition of nuclear factor kappa b/Nlrp3 pathway

Zhang

Wang

et al. 2016

FEBS Open Bio

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Immunoglobulin A nephropathy (IgAN) is the most frequent form of glomerulonephritis, which is characterized by glomerular proliferation and renal inflammation. Icariin is a flavonoid from the Chinese herb Epimedium, and its anti‐inflammatory effect has been reported. This study aimed to investigate the effects of icariin on the renal damage in IgAN rats and the mechanisms behind these effects. IgAN model was established in Sprague–Dawley rats by oral and intravenous immunization with bovine gamma‐globulin for 12 weeks, and rats were treated with icariin from 12 to 18 weeks. At the end of experimental period, kidneys, urine, and blood samples were collected for further analysis. Our results showed that icariin ameliorated the increase in the levels of proteinuria, serum creatinine, and urea nitrogen without severe side effects. IgAN rats exhibited significantly increased IgA deposition, mesangial matrix expansion, and glomerular fibrosis, while icariin treatment markedly attenuated these alterations. Moreover, treatment with icariin also dramatically blocked nuclear factor kappa b (NF‐κB) nuclear translocation and Nlrp3 inflammasome activation in IgAN rats, leading to reduced downstream proinflammatory cytokines production. Mechanistically, we found that icariin treatment inhibited IKKβ and IκBα phosphorylation and IκBα degradation in IgAN rats. Our data demonstrate that icariin ameliorates renal damage in IgAN rats via inhibition of NF‐κB‐mediated Nlrp3 inflammasome activation. These findings provide insight into an application of icariin for the treatment of IgAN disease, and represent a novel mechanism behind these effects.

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Icariin exerts an antidepressant effect in an unpredictable chronic mild stress model of depression in rats and is associated with the regulation of hippocampal neuroinflammation

Cited by 171 publications

References 50 publications

Danger Signals and Inflammasomes: Stress-Evoked Sterile Inflammation in Mood Disorders

Danger Signals and Inflammasomes: Stress-Evoked Sterile Inflammation in Mood Disorders

A review on antidepressant effect of medicinal plants

Icariin ameliorates IgA nephropathy by inhibition of nuclear factor kappa b/Nlrp3 pathway

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