Icariin inhibits the inflammation through down-regulating NF-κB/HIF-2α signal pathways in chondrocytes

Wang, Pengzhen; Meng, Qingqi; Wang, Wen; Zhang, Shaoheng; Xiong, Xuming; Qin, Shengnan; Zhang, Jinli; Li, Aiguo; Liu, Zhihe

doi:10.1042/bsr20203107

Cited by 47 publications

(39 citation statements)

References 35 publications

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“…A study reported that icariin can inhibit NF-κB activation and nuclear translocation triggered by TNF-α, as well as reduce chondrocyte apoptosis and inflammation ( Mi et al, 2018 ). In addition, according to the study of Pengzhen Wang et al (2020) , icariin inhibited the activation of NF-κB and HIF-2α in the chondrocytes of OA mice and attenuated the inflammatory response driven by TNF-α. In addition, the expression of MMPs was inhibited.…”

Section: Discussionmentioning

confidence: 99%

Icariin: A Potential Molecule for Treatment of Knee Osteoarthritis

et al. 2022

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Background: Knee osteoarthritis (KOA) is a degenerative disease that develops over time. Icariin (ICA) has a positive effect on KOA, although the mechanism is unknown. To investigate drug-disease connections and processes, network pharmacology is commonly used. The molecular mechanisms of ICA for the treatment of KOA were investigated using network pharmacology, molecular docking and literature research approaches in this study.Methods: We gathered KOA-related genes using the DisGeNET database, the OMIM database, and GEO microarray data. TCMSP database, Pubchem database, TTD database, SwissTargetPrediction database, and Pharmmapper database were used to gather ICA-related data. Following that, a protein-protein interaction (PPI) network was created. Using the Metascape database, we performed GO and KEGG enrichment analyses. After that, we built a targets-pathways network. Furthermore, molecular docking confirms the prediction. Finally, we looked back over the last 5 years of literature on icariin for knee osteoarthritis to see if the findings of this study were accurate.Results: core targets relevant to KOA treatment include TNF, IGF1, MMP9, PTGS2, ESR1, MMP2 and so on. The main biological process involved regulation of inflammatory response, collagen catabolic process, extracellular matrix disassembly and so on. The most likely pathways involved were the IL-17 signaling pathway, TNF signaling pathway, Estrogen signaling pathway.Conclusion: ICA may alleviate KOA by inhibiting inflammation, cartilage breakdown and extracellular matrix degradation. Our study reveals the molecular mechanism of ICA for the treatment of KOA, demonstrating its potential value for further research and as a new drug.

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Section: Discussionmentioning

confidence: 99%

Icariin: A Potential Molecule for Treatment of Knee Osteoarthritis

et al. 2022

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“…et Zucc.) Maxim., Epimedium pubescens Maxim., or Epimedium koreanum Nakai), is a typical flavonoid compound with antiinflammatory, anti-oxidative (Zuo et al, 2019), and boneprotective properties (Wang et al, 2020). ICA can treat OA through multiple pathways and targets.…”

Section: Icariinmentioning

confidence: 99%

“…ICA can treat OA through multiple pathways and targets. It increases the vitality of chondrocytes through reducing the inflammatory damage caused by NF-κB/HIF-2α signaling (Wang et al, 2020); regulates chondrocyte autophagy by mediating the PI3K/Akt/ mTOR pathway (Tang et al, 2021) and inhibiting NF-κB; alleviates OA by inhibiting inflammatory cytokines and chondrocyte apoptosis (Liu et al, 2018a;Mi et al, 2018); upregulates the proliferation, osteogenic, and chondrogenic differentiation of bone marrow-derived MSCs (BMSCs); and protects BMSCs from apoptosis through the mitogen-activated protein kinase (MAPK) signaling pathway (Liu et al, 2020a). In a study on ICA and human OA fibroblast-like synoviocytes, it was found that ICA could inhibit the expression of IL-1β, MMP4, and glucose-regulated protein 78 (GRP78), which further reduces the inflammatory response (Pan et al, 2017).…”

Section: Icariinmentioning

confidence: 99%

Botanical Drug Extracts Combined With Biomaterial Carriers for Osteoarthritis Cartilage Degeneration Treatment: A Review of 10 Years of Research

Feng

et al. 2022

Front. Pharmacol.

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Osteoarthritis (OA) is a long-term chronic arthrosis disease which is usually characterized by pain, swelling, joint stiffness, reduced range of motion, and other clinical manifestations and even results in disability in severe cases. The main pathological manifestation of OA is the degeneration of cartilage. However, due to the special physiological structure of the cartilage, once damaged, it is unable to repair itself, which is one of the challenges of treating OA clinically. Abundant studies have reported the application of cartilage tissue engineering in OA cartilage repair. Among them, cell combined with biological carrier implantation has unique advantages. However, cell senescence, death and dedifferentiation are some problems when cultured in vitro. Botanical drug remedies for OA have a long history in many countries in Asia. In fact, botanical drug extracts (BDEs) have great potential in anti-inflammatory, antioxidant, antiaging, and other properties, and many studies have confirmed their effects. BDEs combined with cartilage tissue engineering has attracted increasing attention in recent years. In this review, we will explain in detail how cartilage tissue engineering materials and BDEs play a role in cartilage repair, as well as the current research status.

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“…By the analysis of cultured HIF-2α-deficient ECs Skuli et al did, the mechanism of HIF-2α regulating the process of pathological angiogenesis and revascularization may be related to HIF-2α-dependent expression of specific angiogenic factors, which involve angiopoietin 2, a Notch ligand and delta-like ligand 4 (Dll4) (15). HIF-2α directly or indirectly regulates the expression of many genes, the induced genes involving angiogenesis are upregulated, such as basic fibroblast growth factor (bFGF) (16), vascular endothelial growth factor A (VEGF-A) (17), and tumor necrosis factor alpha (TNF-α), platelet-derived growth factor (PDGF) (18), extracellular matrix (ECM) also plays a certain role in angiogenesis, and MMPs is one of the main proteases involved in ECM degradation, HIF-2α can also promote angiogenesis by regulating the expression of MMPS (19).…”

Section: Hif-2α and Angiogenesismentioning

confidence: 99%

A narrative review of research progress on the relationship between hypoxia-inducible factor-2α and wound angiogenesis

Xu¹,

Zhang²,

Guo³

et al. 2021

Ann Palliat Med

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Objective: This article aims to pay attention to the latest research on the expression, activation and function of hypoxia-inducible factor-2α (HIF-2α) under hypoxia and non-hypoxia conditions, and summarizes the current knowledge about the interaction between hypoxia-inducible factor-2 and angiogenesis, hoping to understand its actions in physiology and disease, with the goal of providing a new strategy for the diagnosis and treatment of wounds.Background: Wound healing is a complex and continuous process, involving coagulation, inflammation, angiogenesis, new tissue formation and extracellular matrix remodeling. Of these, angiogenesis is an essential step. One of the main reasons for non-healing or delayed healing of wounds in peripheral vascular diseases and diabetes is the reduced ability to regenerate microvessels through the process of angiogenesis, which has become the focus of new methods for treating chronic wounds. HIF-2α regulates many aspects of angiogenesis, including vascular maturation, cell migration, proliferation and metastasis.Methods: Throughout extensive search of PubMed, summarize the medical research on HIF-2α to 2020.Conclusions: HIF-2α is necessary for normal embryonic development by stimulating the expression of angiogenic factors, such as vascular endothelial growth factor (VEGF). It is essential for the formation of new blood vessels in physiological and pathophysiological environments. Targeting HIF-2α in wound healing has much clinical significance for tissue repair.

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Icariin inhibits the inflammation through down-regulating NF-κB/HIF-2α signal pathways in chondrocytes

Cited by 47 publications

References 35 publications

Icariin: A Potential Molecule for Treatment of Knee Osteoarthritis

Icariin: A Potential Molecule for Treatment of Knee Osteoarthritis

Botanical Drug Extracts Combined With Biomaterial Carriers for Osteoarthritis Cartilage Degeneration Treatment: A Review of 10 Years of Research

A narrative review of research progress on the relationship between hypoxia-inducible factor-2α and wound angiogenesis

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