Icariin-Mediated Inhibition of NF-κB Activity Enhances the In Vitro and In Vivo Antitumour Effect of 5-Fluorouracil in Colorectal Cancer

Shi, De Bing; Li, Xin Xiang; Zheng, Hong; Li, Da Wei; Cai, Guo-Jun; Peng, Jun; Gu, Wei; Guan, Zu Qing; Xu, Ye; Cai, San Jun

doi:10.1007/s12013-014-9827-5

Cited by 34 publications

(19 citation statements)

References 46 publications

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“…In contrast, icariin was able to abrogate the effects of LPS on neuroinflammation, lung inflammation, osteoclast differentiation and bone resorption via decreasing NF-κB activity (23,49,54,55). It has also been reported that icariin inhibits NF-κB activity in a wide range of cancerous cells (56)(57)(58)(59). The results of the present study demonstrated that icariin suppresses the cytokine-induced activation of NF-κB in rat pancreatic β cells.…”

Section: Discussionsupporting

confidence: 41%

Icariin prevents cytokine‑induced β‑cell death by inhibiting NF‑κB signaling

Zhong

2018

Exp Ther Med

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Abstract. The loss of insulin secretion in type I diabetes mellitus (T1DM) is caused by autoimmune-mediated destruction of insulin-producing pancreatic β-cells. Inflammatory cytokines and immune cell infiltration activate oxidative and endoplasmic reticulum (ER) stress, resulting in reduced β-cell viability. The current pharmacological agents used to control blood glucose have a limited effective duration and are accompanied by strong side effects. Blocking the inflammatory and immune responses that cause the β-cell damage has been investigated as a novel therapeutic approach to control T1DM. Icariin is a flavonoid component of Chinese medicinal herbs that has anti-inflammatory effects in vitro and in vivo. The results of the present study revealed that icariin abrogates the pro-apoptotic effect of inflammatory cytokines and significantly suppresses the activation of nuclear factor (NF)-κB in rat pancreatic β-cell lines. The present study may provide a basis for the potential use of icariin as a therapeutic agent for T1DM.

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Section: Discussionsupporting

confidence: 41%

Icariin prevents cytokine‑induced β‑cell death by inhibiting NF‑κB signaling

Zhong

2018

Exp Ther Med

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“…A previous research disclosed that the drug target of ICA might be related to the increase of cAMP/cGMP ratio (ZHU and LOU, 2006). The related researches uncovered that ICA exerted the antitumor functions mainly in inducing apoptosis and differentiation, prohibiting invasion and metastasis, restraining angiogenesis, and reducing toxicity of radiotherapy and chemotherapy (Yang et al, 2015;Gui et al, 2018;Shi et al, 2014). Among these, the mechanism of SPARC involved in tumorigenesis includes inducing differentiation, inhibiting invasion and metastasis, and restraining angiogenesis of cancer cells (Chen et al, 2012;Ma et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Retracted: Icariin inhibits proliferation, migration, and invasion of medulloblastoma DAOY cells by regulation of SPARC

Yang

2020

Phytotherapy Research

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Icariin (ICA) is obtained from Epimedium brevicornu maxim and exploited to remedy miscellaneous cancers. But the role of ICA in medulloblastoma remains hazy. The research delved into the antitumor activity of ICA in medulloblastoma DAOY cells. ICA with diverse concentrations was utilized to stimulate DAOY cells, and the biological functions of ICA in medulloblastoma DAOY cells were examined. Then, the relative SPARC expression was determined in ICA‐managed DAOY cells, and the pc‐SPARC vector was transfected into DAOY cells to further probe the influence of SPARC and JAK1/STAT3 and PI3K/AKT pathways in ICA‐managed DAOY cells. A xenograft model was established to investigate the function of ICA in vivo. ICA restrained cell viability, expedited apoptosis, prohibited cell migration and invasion, and meanwhile affected the associative factors expression in DAOY cells. Additionally, SPARC expression was declined in ICA‐stimulated DAOY cells. Overexpressed SPARC reversed the functions of ICA in above‐involved cell behaviors of DAYO cells and the correlative protein levels. Besides, ICA notably frustrated JAK1/STAT3 and PI3K/AKT activations in DAOY cells. Beyond that, ICA prohibited tumor formation in vivo. The results concluded that ICA exhibited the antitumor activity in DAOY cells via decreasing SPARC and inactivating JAK1/STAT3 and PI3K/AKT pathways.

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“…Icariin has also been reported to exhibit anticancer activity against various cancer cell lines. It mainly induced apoptosis via ROS generation and inhibiting NF-КB translocation into nucleus 53 , 54 . Chemical profile of Icariin treated animals demonstrated that Icariside II is the major pharmacological active form of Icariin in vivo 50 , 52 , 55 .…”

Section: Natural Sourcesmentioning

confidence: 99%

Targeting Apoptosis and Multiple Signaling Pathways with Icariside II in Cancer Cells

Khan¹,

Maryam²,

Qazi³

et al. 2015

Int. J. Biol. Sci.

123

119

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Cancer is the second leading cause of deaths worldwide. Despite concerted efforts to improve the current therapies, the prognosis of cancer remains dismal. Highly selective or specific blocking of only one of the signaling pathways has been associated with limited or sporadic responses. Using targeted agents to inhibit multiple signaling pathways has emerged as a new paradigm for anticancer treatment. Icariside II, a flavonol glycoside, is one of the major components of Traditional Chinese Medicine Herba epimedii and possesses multiple biological and pharmacological properties including anti-inflammatory, anti-osteoporosis, anti-oxidant, anti-aging, and anticancer activities. Recently, the anticancer activity of Icariside II has been extensively investigated. Here, in this review, our aim is to give our perspective on the current status of Icariside II, and discuss its natural sources, anticancer activity, molecular targets and the mechanisms of action with specific emphasis on apoptosis pathways which may help the further design and conduct of preclinical and clinical trials.Icariside II has been found to induce apoptosis in various human cancer cell lines of different origin by targeting multiple signaling pathways including STAT3, PI3K/AKT, MAPK/ERK, COX-2/PGE2 and β-Catenin which are frequently deregulated in cancers, suggesting that this collective activity rather than just a single effect may play an important role in developing Icariside II into a potential lead compound for anticancer therapy. This review suggests that Icariside II provides a novel opportunity for treatment of cancers, but additional investigations and clinical trials are still required to fully understand the mechanism of therapeutic effects to further validate it in anti-tumor therapy.

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Icariin-Mediated Inhibition of NF-κB Activity Enhances the In Vitro and In Vivo Antitumour Effect of 5-Fluorouracil in Colorectal Cancer

Cited by 34 publications

References 46 publications

Icariin prevents cytokine‑induced β‑cell death by inhibiting NF‑κB signaling

Icariin prevents cytokine‑induced β‑cell death by inhibiting NF‑κB signaling

Retracted: Icariin inhibits proliferation, migration, and invasion of medulloblastoma DAOY cells by regulation of SPARC

Targeting Apoptosis and Multiple Signaling Pathways with Icariside II in Cancer Cells

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