2021
DOI: 10.1021/acs.molpharmaceut.0c00937
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ICG/l-Arginine Encapsulated PLGA Nanoparticle-Thermosensitive Hydrogel Hybrid Delivery System for Cascade Cancer Photodynamic-NO Therapy with Promoted Collagen Depletion in Tumor Tissues

Abstract: Photodynamic therapy (PDT) is promising for clinical cancer therapy; however, the efficacy was limited as an individual treatment regimen. Here, an approach synergistically combining PDT and nitric oxide (NO) gas therapy along with destruction of the tumor extracellular matrix (ECM) was presented to eliminate cancer. Specifically, the NO donor L-arginine (L-Arg) and the photosensitizer indocyanine green (ICG) were co-encapsulated in poly(lactic-glycolic acid) (PLGA) nanoparticles and then loaded into the poly(… Show more

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Cited by 50 publications
(36 citation statements)
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“…Therefore, the RNS generated by ROS and NO could activate MMPs in tumor cells which could further degrade the collagen in the extracellular matrix, which modulated the TME, leading to the improved drug sensitivity and immunotherapy. In animal experiments, the bioluminescent imaging signal intensity in mice treated with this method showed a significant increase in the efficiency of tumor growth inhibition of up to 60% (Figure 4D) [86]. In addition to PTT, PDT is also an effective approach to trigger the release of NO [143].…”
Section: Nir Photodynamic Triggered No Nanomedicinesmentioning
confidence: 94%
See 1 more Smart Citation
“…Therefore, the RNS generated by ROS and NO could activate MMPs in tumor cells which could further degrade the collagen in the extracellular matrix, which modulated the TME, leading to the improved drug sensitivity and immunotherapy. In animal experiments, the bioluminescent imaging signal intensity in mice treated with this method showed a significant increase in the efficiency of tumor growth inhibition of up to 60% (Figure 4D) [86]. In addition to PTT, PDT is also an effective approach to trigger the release of NO [143].…”
Section: Nir Photodynamic Triggered No Nanomedicinesmentioning
confidence: 94%
“…The breaking of bonds NO therapy [82] L-Arg@PCN@Mem L-Arg Oxidation-reduction reaction NO therapy-PDT [83] Arg-ZnPc L-Arg Oxidation-reduction reaction NO therapy-PDT [84] ADLAu@CuS YSNPs L-Arg Oxidation-reduction reaction NO therapy-PDT-chemotherapy [85] PLGA@ICG@L-Arg L-Arg Oxidation-reduction reaction NO therapy-PDT [86] Lyso-Ru-NO@FA@C-TiO 2 Ru-NO The breaking of bonds NO therapy-PDT [87] US BNN6-SPION@hMSN BNN6…”
Section: Go-bnn6 Bnn6mentioning
confidence: 99%
“…Depending on the polymers employed in their production, hydrogels can be biocompatible, biodegradable, and present minimal toxicity. They can encapsulate molecules in an effective amount, protecting and releasing them over time while increasing their local concentration and reducing their toxicity in the remaining tissues [ 28 ]. Moreover, hydrogels kinetics can respond to biological, chemical, or physical external stimuli.…”
Section: Nps-loaded Hydrogel Systemmentioning
confidence: 99%
“…Subcutaneous applications of these NLH systems have also been widely explored for other biomedical applications by increasing drugs' bioavailability and improving therapies, such as in the case of cancer treatments, as proposed by Sun et al (2021) [28]. The authors developed an injectable thermosensitive hydrogel containing poly(lactic-glycolic acid) (PLGA) NPs as a synergic approach to destroy the tumor's extracellular matrix.…”
Section: Routes Of Drugs Administrationmentioning
confidence: 99%
“…Combination treatment with an activator is partly owing to the combination of a promising potential anticancer drugs. The dosage proportion of two drugs, as well as the potential competitive molecules, decide the composition of an effective antitumor drug delivery system (Liang & Kiick, 2016 ; Brus et al, 2017 ; Sun et al, 2021 ; Wolfe et al, 2021 ). As a result, the prominence of maintaining a beneficial association in order to continue compatibility between the various components by biodegradable nanoparticle delivery cannot be overstated.…”
Section: Introductionmentioning
confidence: 99%