Visions of future advances in science and and technology (S&T) inevitably bring with them wideranging common visions on how cities as social fabrics will evolve in the future as well as on the immense opportunities and potential risks this future will bring. Situated within what is described as science of science, this study analyzes the nature, practice, and impact of ICT of the new wave of computing for urban sustainability as a form of S&T. Specifically, it probes the ways in which this form has emerged from a variety of perspectives, and why it has become institutionalized and interwoven with politics and policy-urban dissemination-within the defining context of smart sustainable cities. Also, it addresses the risks this form poses to environmental sustainability in the context thereof. To achieve these aims, an analytical and philosophical framework of Science and Technology Studies (STS) is adopted, which supports analyses and evaluations whose approaches are drawn from a variety of disciplinary and theoretical perspectives. The study shows that smart sustainable cities are produced by the socially constructed understandings and socially anchored and institutionalized practices pertaining to ICT of the new wave of computing for urban sustainability and thus medicated by ecologically and technologically advanced societies. Accordingly, these cities as a manifestation of scientific knowledge and technological innovation are shaped by and also shape techno-scientific, socio-cultural, and politico-institutional structures. Moreover, the study demonstrates that the success and expansion of ICT of the new wave of computing for urban sustainability and thus smart sustainable cities stem from the morphing power, knowledge/power relation, productive and constitutive force, and legitimation capacity underlying computing and ICT as science and science-based technology. These are, however, shown to pose risks to environmental sustainability. Hence, they need to be reoriented in a more environmentally sustainable direction, as they can not, as currently practiced, solve the environmental problems placed in the agenda of smart and sustainable cities as a holistic approach to sustainable urban development.