ICTV Virus Taxonomy Profile: Papillomaviridae

Doorslaer, Koenraad Van; Chen, Zigui; Bernard, Hans Ulrich; Chan, Paul K.S.; DeSalle, Rob; Dillner, Joakim; Forslund, Ola; Haga, Takeshi; McBride, Alison A.; Villa, Luisa L.; Burk, Robert D.

doi:10.1099/jgv.0.001105

Cited by 166 publications

(189 citation statements)

References 7 publications

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“…1b). The suggested ICTV criteria for naming a new genera require an L1 nucleotide identity of approximately < 60% [33][34][35]. A distribution of pair-wise distances shows that L1 sequences classified with the same species generally showed identity of 70-100% [33,34].…”

Section: Taupapillomavirus Genomesmentioning

confidence: 99%

Nasal virome of dogs with respiratory infection signs include novel taupapillomaviruses

et al. 2019

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Using viral metagenomics, we characterized the mammalian virome of nasal swabs from 57 dogs with unexplained signs of respiratory infection showing mostly negative results using the IDEXX Canine Respiratory Disease RealPCR™ Panel. We identified canine parainfluenza virus 5, canine respiratory coronavirus, carnivore bocaparvovirus 3, canine circovirus and canine papillomavirus 9. Novel canine taupapillomaviruses (CPV21-23) were also identified in 3 dogs and their complete genome sequenced showing L1 nucleotide identity ranging from 68.4 to 70.3% to their closest taupapillomavirus relative. Taupapillomavirus were the only mammalian viral nucleic acids detected in two affected dogs, while a third dog was coinfected with low levels of canine parainfluenza 5. A role for these taupapillomavirues in canine respiratory disease remains to be determined.Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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Section: Taupapillomavirus Genomesmentioning

confidence: 99%

Nasal virome of dogs with respiratory infection signs include novel taupapillomaviruses

et al. 2019

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“…According to the most recent ICTV classification, the PV family includes two subfamilies Firstpapillomavirinae with 52 genera and Secondpapillomavirinae with one genus and one species (Van Doorslaer et al 2018). Genera are named according to the Greek alphabet from alpha to omega, and following exhaustion of the alphabet the term dyo and treis (Greek for second time and third, respectively) coined to accommodate the extra genera e.g.…”

Section: Electronic Supplementary Materialsmentioning

confidence: 99%

Recombination Between High-Risk Human Papillomaviruses and Non-Human Primate Papillomaviruses: Evidence of Ancient Host Switching Among Alphapapillomaviruses

2020

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We use all the currently known 405 Papillomavirus (PV) sequences, 343 curated PV sequences from both humans and animals from the PAVE data base, to analyse the recombination dynamics of these viruses at the whole genome levels. After showing some evidence of human and non-human primate PV recombination, we report a comprehensive recombination analysis of all currently known 82 Alphapapillomaviruses (Alpha-PVs). We carried out an exploratory study and found novel recombination events between High-Risk HPV Types and Macaca fascicularis PV1 (MfPV1), Macaca Fuscata PV2 (MfuPV2) and Pan Paniscus PV1 (PpPV1) Papillomaviruses. This is the first evidence of interactions between PVs from different hosts and hence postulates the likelihood of ancient host switching among Alpha-PVs. Notwithstanding these results should be interpreted with caution because the major and minor parents indicated by RDP4 program are simply the sequences in the alignment that most closely resemble the actual parents. We found statistically significant differences between the phylogenies of the PV sequences with recombination regions and PV sequences without recombination regions using the Shimodaira-Hasegawa phylogenetic incongruence testing. We show that not more than 76MYA Alpha-PVs were in the same biological niche, a pre-requisite for recombination, and as the hosts evolved and diversified, the viruses adapted to specific host niches which eventually led to coevolution with specific hosts before speciation of primate species. Thus providing evidence that in ancient times no earlier than the Cretaceous period of the Mesozoic age, Alpha-PVs recombined and switched hosts, but whether this host switching is occurring currently is unknown. However, a clearer picture of the PVs evolutionary landscape can only be achieved with the incremental discovery of PV sequences, especially from the animal kingdom.

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“…Human papillomavirus (HPV) is a double-stranded DNA virus of the Papillomaviridae family [1]. There are more than 200 genotypes of HPV that have been identified, among which 15 (16,18,31,33,35,39,45,51,52,56,58,59, 68, 73, and 82) are highly associated with cervical cancer [2,3].…”

Section: Introductionmentioning

confidence: 99%

Application of the Cobas 4800 System for the Detection of High-Risk Human Papillomavirus in 5650 Asymptomatic Women

Wang

Meng

et al. 2020

BioMed Research International

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High-risk papillomavirus (HR-HPV) testing combined with cytology improves the detection of cervical lesions and increases length of screening intervals. For a population-based HR-HPV survey, testing automation is in great need. The Cobas 4800 HPV Test System is a fully automated assay that can simultaneously detect HPV16, HPV18, and other 12 pooled HR-HPV genotypes. This system has been employed for HR-HPV screening in a number of countries; however, such application in a large population in China has not been documented. In this study, we employed the Cobas 4800 HPV Test System to detect HR-HPV in cervical cytology specimens collected from a total of 5650 asymptomatic women from a region of South China. We reported the following: (1) the prevalence of the 14 genotypes of HR-HPV was 12.96%; (2) for those with HR-HPV infection, 2.25% were positive for HPV16, 0.50% for HPV18, 9.15% for pooled 12 HPV types, and 1.06% for multiple HPV infection; and (3) there was no significant difference in the HR-HPV prevalence among different age groups. HPV16 and HPV18 have been shown to be the predominant HPV types found in cervical cancer patients in some regions in China, indicating that a fully automated assay like the Cobas 4800 HPV Test System is especially valuable for population-based HR-HPV screening in these regions as this assay can concurrently detect HPV16 and HPV18.

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ICTV Virus Taxonomy Profile: Papillomaviridae

Cited by 166 publications

References 7 publications

Nasal virome of dogs with respiratory infection signs include novel taupapillomaviruses

Nasal virome of dogs with respiratory infection signs include novel taupapillomaviruses

Recombination Between High-Risk Human Papillomaviruses and Non-Human Primate Papillomaviruses: Evidence of Ancient Host Switching Among Alphapapillomaviruses

Application of the Cobas 4800 System for the Detection of High-Risk Human Papillomavirus in 5650 Asymptomatic Women

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