Nasal virome of dogs with respiratory infection signs include novel taupapillomaviruses

Altan, Eda; Seguin, M. Alexis; Leutenegger, Christian M.; Phan, Tung Gia; Deng, Xutao; Delwart, Eric

doi:10.1007/s11262-019-01634-6

Cited by 18 publications

(14 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to the literature, CPV 9 and CPV 15 have only been reported in benign lesions [20,52]. In the present study, CPV 9 was identified in a dog with multiple cutaneous neoplasms, including multiple skin papillomas, cutaneous horn, and SCCs (case no.…”

Section: Discussionsupporting

confidence: 49%

The Detection and Association of Canine Papillomavirus with Benign and Malignant Skin Lesions in Dogs

Chang

Chen

Haga

et al. 2020

Viruses

View full text Add to dashboard Cite

Papillomavirus (PV) mainly infects the squamous epithelium and may potentially lead to benign or even malignant cutaneous lesions. However, the malignant transforming ability has been identified in several types of PVs. In humans, papillomavirus (HPV) type 16 and 18 are the most prevalent causative agents of cervical cancer. Therefore, vaccines are being developed to protect against these types. For dogs, there have been limited investigations into the association of different canine papillomavirus (CPV) genotypes with malignant lesions. Understanding the high-risk CPV genotype(s) responsible for these malignant lesions would contribute to the development of interventions for preventing CPV-induced carcinomas. In the present study, a retrospective cohort of 102 pathologically confirmed papillomas and 212 squamous cell carcinomas (SCCs) were included. The viral genome and antigens in the formalin-fixed paraffin-embedded (FFPE) tissues were detected using PCR targeting pan PV E1 and COPV L1 genes and by immunohistochemistry staining (IHC), respectively. PVs were successfully detected from 11 FFPE cutaneous tissues and four oral tissues using pan PV E1- and COPV L1-based PCR, respectively. After sequencing, CPV 1, CPV 2, and CPV 6 were detected in the benign lesions using PCR and were confirmed through IHC. While CPV 9 and CPV 15 were first detected in the SCCs of dogs, CPV 16 was most often detected in SCC specimens. The association and confirmative demonstration of viral genes and intralesional antigens of CPV 9, CPV 15, and CPV 16 in SCCs highlight the potential risk of these genotypes of CPVs in malignant transformation.

show abstract

Section: Discussionsupporting

confidence: 49%

The Detection and Association of Canine Papillomavirus with Benign and Malignant Skin Lesions in Dogs

Chang

Chen

Haga

et al. 2020

Viruses

View full text Add to dashboard Cite

show abstract

“…Carnivora host-associated papillomaviruses belong to the genera Chi -, Lambda -, Tau -, Omega -, Treiseta -, Dyotheta - and Dyonupapillomavirus . The most studied PVs of Carnivora hosts are from domestic dogs (types CPV1—CPV23), belonging to the genera Chi -, Lambda - and Taupapillomavirus [ 8 , 13 , 26 ]. Within the mustelids, PVs have only been reported in southern sea otters infected with Enhydra lutris papillomavirus 1 (ElPV1), which causes oral papillomatosis [ 56 ], and in fecal material from a ferret infected with Mustela putorius papillomavirus 1 (MpPV1) [ 57 ].…”

Section: Discussionmentioning

confidence: 99%

“…PVs have been found not only in mammals, but also in fish [ 19 ], birds [ 20 , 21 , 22 ] and reptiles [ 23 , 24 ]. The most studied PVs in animals are from domestic hosts, including cattle [ 7 , 8 , 25 ], dogs [ 8 , 26 ], cats [ 8 , 27 , 28 ], horses [ 29 , 30 ], and sheep [ 31 , 32 ]. In addition to domestic animals, PVs have also been studied in various wildlife hosts, such as the ocelot [ 33 ], bottlenose dolphin [ 34 ], gray wolf [ 35 ], red fox [ 36 ], European badger [ 37 ], tree shrew [ 38 ], giant panda [ 39 ], roe and red deer [ 40 , 41 , 42 , 43 , 44 , 45 ], etc.…”

Section: Introductionmentioning

confidence: 99%

Identification of a Novel Papillomavirus Type (MfoiPV1) Associated with Acrochordon in a Stone Marten (Martes foina)

et al. 2021

View full text Add to dashboard Cite

Papillomaviruses (PVs) are an extremely large group of viruses that cause skin and mucosal infections in humans and various domestic and wild animals. Nevertheless, there is limited knowledge about PVs in wildlife hosts, including mustelid species. This study describes a case in stone marten (Martes foina) with a clinical manifestation of skin tumor, which is rather atypical for infections with PVs. The result of the papillomavirus PCR performed on the skin tumor sample was positive, and the complete PV genome was determined in the studied sample using next-generation sequencing technology. The analysis of the PV genome revealed infection of the stone marten with a putative new PV type belonging to the Dyonupapillomavirus genus. The proposed new stone marten PV type was named MfoiPV1.

show abstract

“…Viral pathogens are the main cause of CIRD, with common causes including canine coronavirus (CCoV), canine parainfluenza virus, canine adenovirus type 2 (CAV-2) and canine distemper virus. However, emerging respiratory viruses have been continuously found in dogs, including severe acute respiratory syndrome coronavirus 2 and canine taupapillomavirus (Altan et al, 2019;Sit et al, 2020). To date, the viruses associated with CIRD remain unclear in China and require further study.…”

Section: Introductionmentioning

confidence: 99%

“…Interestingly, CPnV and DogPyV were first detected in China. Recently,Altan et al (2019) have characterized only six viruses from dogs with CIRD in the USA using metagenomics. These results indicated that the viral communities of CIRD in China were more complex and diverse than elsewhere.…”

mentioning

confidence: 99%

An emerging orthopneumovirus detected from dogs with canine infectious respiratory disease in China

Song

Huang

et al. 2021

Transbound Emerg Dis

View full text Add to dashboard Cite

Canine infectious respiratory disease (CIRD) is a major cause of morbidity in dogs and is associated with several viral pathogens. The viral diversity associated with CIRD was investigated by analyzing the viral communities from nine CIRD-affected dogs using metagenomics. The results identified 10 mammalian viruses, including canine parvovirus, canid alphaherpesvirus 1, canine kobuvirus, Felis catus papillomavirus 3, canine respiratory coronavirus, canine adenovirus 2, Canis familiaris polyomavirus (DogPyV), canine coronavirus, human papillomavirus and canine pneumovirus (CPnV). Interestingly, CPnV and DogPyV were first discovered in China. Further investigation in 107 samples in China using specific PCR found only two CPnV positive strains in 51 CIRD samples and none in 56 healthy samples. Furthermore, a complete nucleotide sequence of CPnV strain SMU-2020-CB19 and a partial nucleotide sequence of strain SMU-2020-CB14 were obtained. Sequence comparisons and phylogenetic analysis showed that both novel CPnV strains were a close match to the detected swine orthopneumovirus strain in USA, but distantly related to other CPnV strains. Here, the first discovery and characterization of orthopneumovirus in dogs with CIRD in China were reported, highlighting the need for further research on pathogenicity and transmission in China.

show abstract

Nasal virome of dogs with respiratory infection signs include novel taupapillomaviruses

Cited by 18 publications

References 34 publications

The Detection and Association of Canine Papillomavirus with Benign and Malignant Skin Lesions in Dogs

The Detection and Association of Canine Papillomavirus with Benign and Malignant Skin Lesions in Dogs

Identification of a Novel Papillomavirus Type (MfoiPV1) Associated with Acrochordon in a Stone Marten (Martes foina)

An emerging orthopneumovirus detected from dogs with canine infectious respiratory disease in China

Contact Info

Product

Resources

About