ID Proteins May Reduce Aggressiveness of Thyroid Tumors

Amaral, Laís Helena Pereira; Bufalo, Natassia Elena; Peres, Karina Colombera; Barreto, Icléia Siqueira; Campos, Antônio Hugo José Fróes Marques; Ward, Laura Sterian

doi:10.1007/s12022-018-9556-1

Cited by 6 publications

(8 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All these demonstrate that Id4 may act as an invasion suppressor in lung cancer progression. The data of this study, showing that Id4 may act to impede the evolution of lung cancer metastasis, are similar to those from prostate cancer [41,42], glioblastoma [44], and thyroid tumors [52]. Recently, Nasif and his colleague demonstrated that Id4 is significantly methylated in ER+ breast tumors [40].…”

Section: Discussionsupporting

confidence: 74%

See 1 more Smart Citation

Inhibitor of DNA-Binding Protein 4 Suppresses Cancer Metastasis through the Regulation of Epithelial Mesenchymal Transition in Lung Adenocarcinoma

Wang

Hsu

Chang

et al. 2019

Cancers

View full text Add to dashboard Cite

Metastasis is a predominant cause of cancer death and the major challenge in treating lung adenocarcinoma (LADC). Therefore, exploring new metastasis-related genes and their action mechanisms may provide new insights for developing a new combative approach to treat lung cancer. Previously, our research team discovered that the expression of the inhibitor of DNA binding 4 (Id4) was inversely related to cell invasiveness in LADC cells by cDNA microarray screening. However, the functional role of Id4 and its mechanism of action in lung cancer metastasis remain unclear. In this study, we report that the expression of Id4 could attenuate cell migration and invasion in vitro and cancer metastasis in vivo. Detailed analyses indicated that Id4 could promote E-cadherin expression through the binding of Slug, cause the occurrence of mesenchymal-epithelial transition (MET), and inhibit cancer metastasis. Moreover, the examination of the gene expression database (GSE31210) also revealed that high-level expression of Id4/E-cadherin and low-level expression of Slug were associated with a better clinical outcome in LADC patients. In summary, Id4 may act as a metastatic suppressor, which could not only be used as an independent predictor but also serve as a potential therapeutic for LADC treatment.

show abstract

Section: Discussionsupporting

confidence: 74%

“…Cancers 2019, 11, x 11 of 18 [44], and thyroid tumors [52]. Recently, Nasif and his colleague demonstrated that Id4 is significantly methylated in ER+ breast tumors [40].…”

Section: Discussionmentioning

confidence: 99%

Inhibitor of DNA-Binding Protein 4 Suppresses Cancer Metastasis through the Regulation of Epithelial Mesenchymal Transition in Lung Adenocarcinoma

Wang

Hsu

Chang

et al. 2019

Cancers

View full text Add to dashboard Cite

show abstract

“…However, thyroid carcinoma cells can metastasize in the early stages of the disease to lymph nodes through the blood and lymphatic systems, which may lead to recurrence and distant metastasis in 10–20% of patients (21,22). Some cases have a poor response to conventional treatment resulting in a low 10-year survival rate of 20–30% (23,24). Therefore, a better understanding of thyroid carcinoma progression and prognosis prediction is urgently required to improve the outcome of patients with thyroid carcinoma.…”

Section: Introductionmentioning

confidence: 99%

Low expression of ryanodine receptor 2 is associated with poor prognosis in thyroid carcinoma

Zhang

Chen

et al. 2019

Oncol Lett

View full text Add to dashboard Cite

Genetic alterations are vital in the progression of thyroid carcinoma. Ryanodine receptor 2 (RyR2) is reported to serve an important role in several types of human carcinoma. However, the expression and effect of RyR2 in thyroid carcinoma remain unknown. Therefore, the present study analyzed the status of RyR2 in thyroid carcinoma using bioinformatics tools. The mRNA profiles of thyroid carcinoma were downloaded from The Cancer Genome Atlas. RyR2 was distinguished as a differentially expressed gene that has not been reported in thyroid carcinoma. Further analysis indicated that there was selective downregulation of RyR2 expression in thyroid carcinoma tissues compared with that in normal thyroid tissues. Survival analysis showed that RyR2 expression was associated with poorer disease-free survival (DFS) for all patients with thyroid carcinoma. Univariate analysis revealed that a low expression of RyR2 was significantly associated with lymphatic metastasis, extracapsular extension, and the Tumor-Node-Metastasis stage. Cox analysis demonstrated that RyR2 was an independent prognostic factor in thyroid carcinoma for DFS. The biological processes and signaling pathways of RyR2 were reviewed with Gene Set Enrichment Analysis. In conclusion, the present study has revealed that RyR2 is downregulated in thyroid carcinoma, and that low expression of RyR2 is associated with poor prognosis in patients with thyroid carcinoma. RyR2 may therefore serve as a promising tumor suppressor gene in thyroid carcinoma.

show abstract

“…The proposed tumor-suppressing effects of ID4 draw on observations that ID4 undergoes epigenetic silencing in several solid cancers such as esophageal, gastric, pancreatic, colorectal, cholangiocarcinoma and lung cancer. However, ID4 has been reported to be elevated in some small cancers, such as OC, prompting researchers to re-classify it as a tumor promoter (4,52,54,55). Mice de cient in ID4 develop some types of cancers in their lifetime, and the lack of ID4 results in follicular dysplasia and increased atretic follicles due to decreased estrogen biosynthesis (30).…”

Section: Discussionmentioning

confidence: 99%

Inhibitor of DNA-Binding Family Regulates the Prognosis of Ovarian Cancer

et al. 2021

View full text Add to dashboard Cite

Aim: The mechanistic role of inhibitor of DNA binding or differentiation (ID) family in ovarian cancer (OC) has remained unclear. Materials & methods: We used the Oncomine, GEPIA, Kaplan–Meier Plotter, cBioPortal, SurvExpress, PROGgene V2, TIMER, and FunRich to evaluate the prognostic value of IDs in patients with OC. Results: the mRNA transcripts of all IDs were markedly downregulated in OC compared with normal tissue. The prognostic value of IDs was also explored within the subtypes, pathological stages, clinical stages and TP53 mutational status. The group with low-risk IDs showed relatively good overall survival (OS) compared with the high-risk group. Conclusion: ID1/3/4 may be exploited as promising prognostic biomarkers and therapeutic targets in OC patients.

show abstract

ID Proteins May Reduce Aggressiveness of Thyroid Tumors

Cited by 6 publications

References 19 publications

Inhibitor of DNA-Binding Protein 4 Suppresses Cancer Metastasis through the Regulation of Epithelial Mesenchymal Transition in Lung Adenocarcinoma

Inhibitor of DNA-Binding Protein 4 Suppresses Cancer Metastasis through the Regulation of Epithelial Mesenchymal Transition in Lung Adenocarcinoma

Low expression of ryanodine receptor 2 is associated with poor prognosis in thyroid carcinoma

Inhibitor of DNA-Binding Family Regulates the Prognosis of Ovarian Cancer

Contact Info

Product

Resources

About