Id4 modulates salivary gland homeostasis and its expression is downregulated in IgG4-related disease via miR-486-5p

Hayashi, Yoshikazu; Kimura, Soi; Yano, Ena; Yoshimoto, Shohei; Saeki, Ayaka; Yasukochi, Atsushi; Hatakeyama, Yuji; Moriyama, Masafumi; Nakamura, Seiji; Jimi, Eijiro; Kawakubo‐Yasukochi, Tomoyo

doi:10.1016/j.bbamcr.2022.119404

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

2023

DOI: 10.1016/j.bbamcr.2022.119404

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Id4 modulates salivary gland homeostasis and its expression is downregulated in IgG4-related disease via miR-486-5p

Yoshikazu Hayashi

Soi Kimura

Ena Yano

et al.

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2023

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Extraction of characteristic serum microRNAs and prediction of target genes in IgG4-related dacryoadenitis and sialadenitis

Yamamoto,

Tanaka,

Aochi

et al. 2023

Modern Rheumatology

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Objectives To identify the specific microRNAs (miRNAs) in IgG4-related dacryoadenitis and sialadenitis (IgG4-DS) and predict the targeted genes. Methods MiRNAs in the serum of 9 patients with IgG4-DS, 3 patients with primary Sjögren’s syndrome, and 3 healthy controls were analyzed using the human miRNA chip, and miRNAs that exhibited significant fluctuation in expression in IgG4-DS patients were extracted. The respective target genes were predicted using an existing database, and expression of the target genes was evaluated in actual submandibular gland tissues affected by IgG4-DS. Results Serum miR-125a-3p and miR-125b-1-3p levels were elevated in IgG4-DS. Six candidate target genes (glypican 4; forkhead box C1; protein tyrosine phosphatase non-receptor type 3; hydroxycarboxylic acid receptor 1; major facilitator superfamily domain containing 11; and tumor-associated calcium signal transducer 2) were downregulated in the affected submandibular gland tissue. Conclusion Overexpression of miR-125a-3p and miR-125b-1-3p is a hallmark of IgG4-DS. These microRNAs appear to be involved in the pathogenesis of IgG4-DS.

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Extraction of characteristic serum microRNAs and prediction of target genes in IgG4-related dacryoadenitis and sialadenitis

Yamamoto,

Tanaka,

Aochi

et al. 2023

Modern Rheumatology

View full text Add to dashboard Cite

show abstract

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Id4 modulates salivary gland homeostasis and its expression is downregulated in IgG4-related disease via miR-486-5p

Cited by 1 publication

References 76 publications

Extraction of characteristic serum microRNAs and prediction of target genes in IgG4-related dacryoadenitis and sialadenitis

Extraction of characteristic serum microRNAs and prediction of target genes in IgG4-related dacryoadenitis and sialadenitis

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