IDDF2019-ABS-0077 Percutaneous endobiliary radiofrequency ablation and self-expandable metal stent placement versus stent placement alone for malignant biliary obstruction

Cui, Wei; Li, Jiaping

doi:10.1136/gutjnl-2019-iddfabstracts.255

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Full texts of 376 unique studies were evaluated and assessed for eligibility. Ultimately sixteen articles [10,[13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] were selected for our meta-analysis, including thirteen observational studies [13-19, 21-25, 27] and three RCTs(Randomized Controlled Trials) studies [10,20,26]. The search strategy is presented in Figure.1.…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

“…A total of 953 patients were included in this meta-analysis, 447 patients were performed RFA combined stent placement compared with 506 controls only given stent placement. Among those studies, eight studies [10,14,16,17,20,[24][25][26] via ERCP (Endoscopic retrograde Cholangiopancreatography), seven studies [13,15,18,19,21,22,27] used percutaneous transhepatic cholangiography (PTC) to implant stent, ERCP and PTC were mixed used in one research [23]. Types of biliary stents were mentioned in 15 of 16 studies.…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

See 1 more Smart Citation

Radiofrequency Ablation Combined with Stent Placement versus Stent Placement Alone for Malignant Biliary Obstruction: A Systematic Review and Meta-analysis

Chen

Zhu

Sun

2020

Preprint

View full text Add to dashboard Cite

Background: Malignant biliary obstruction was typically diagnosed at an advanced stage due to painless jaundice. Stent placement is the therapy of choice in this set of patients. Radiofrequency ablation is an ablative therapy which has been well recognized for treating malignant biliary strictures. This meta-analysis aims to help to better understand the safety and efficacy of biliary Radiofrequency ablation combined with stent placement. Methods: Five databases (PubMed, Embase, Cochrane Central Register of Controlled Trials, Web of Science, and China National Knowledge Infrastructure) were searched for randomized controlled trials and observational studies up to April 2020. Results: The mean difference in survival time was 54.87 days (95% confidence interval CI, 34.6-75.14), meaning patients performed with radiofrequency ablation benefit more. Reconstructed Kaplan-Meier data showed improved survival in joint intervention with RFA (hazard ratio, 1.39; 95%CI, 1.34-1.75; P < .001). However, no survival benefit was observed in the extrahepatic distal cholangiocarcinoma. With regard to patency time, the mean difference was 42.88 days (95%CI, 34.02-51.37). Reconstructed Kaplan-Meier data showed improved survival in the radiofrequency ablation treated group (hazard ratio, 1.629; 95%CI, 1.35-1.96; P < .001). Concerning postoperative complications such as abdominal pain, cholangitis and pancreatitis, our analysis did not show a significant difference between the radiofrequency ablation treatment group and the controls. Conclusion: Radiofrequency ablation plus stent resulted in improved survival and stent patency, with longer median survival and patency time than stent alone.

show abstract

Section: Study Selection and Characteristicsmentioning

confidence: 99%

Section: Study Selection and Characteristicsmentioning

confidence: 99%

Radiofrequency Ablation Combined with Stent Placement versus Stent Placement Alone for Malignant Biliary Obstruction: A Systematic Review and Meta-analysis

Chen

Zhu

Sun

2020

Preprint

View full text Add to dashboard Cite

show abstract

Comparison of Intraductal RFA Plus Stent versus Stent-Only Treatment for Unresectable Perihilar Cholangiocarcinoma—A Systematic Review and Meta-Analysis

Jong

Fritzsche

Audhoe

et al. 2022

Cancers

View full text Add to dashboard Cite

Background: One of the cornerstones of palliative treatment for unresectable perihilar cholangiocarcinoma is biliary stent placement in order to restore biliary drainage. In this review, the potential added value of RFA with stent placement in comparison to stent placement alone in patients with unresectable perihilar cholangiocarcinoma is analyzed. Methods: We performed a comprehensive online search for relevant articles in November 2021 (PROSPERO ID: CRD42021288180). The primary endpoint was difference in overall survival. Secondary endpoints included overall survival, stent patency and complications. Only studies comparing survival after RFA + stent placement with stent placement alone were included in the meta-analysis. Non-comparative studies or comparative studies describing stent patency only were included in the systematic review. Results: A total of nine studies, including 217 patients with pCCA who underwent RFA + stent placement and 294 patients who underwent stent-only treatment, met the inclusion criteria for the primary endpoint analysis. Direct comparison between the two treatment groups showed a significantly longer overall survival for RFA + stent treatment, with a pooled HR of 0.65 [95% CI, 0.50–0.84, I2 = 38%]. When all eligible studies were included, RFA + stent treatment revealed an overall survival of 9.5 months [95% CI, 6.3–12.6], whereas survival for stent-only treatment was 7.0 months [95% CI, 5.7–8.2]. Due to the heterogeneity of the data, no pooled data analysis could be performed on stent patency or complications. Conclusions: RFA + stent placement displays promising potential to prolong survival. However, further research incorporating confounding factors like use of palliative chemotherapy is necessary in order to validate these findings.

show abstract

IDDF2019-ABS-0077 Percutaneous endobiliary radiofrequency ablation and self-expandable metal stent placement versus stent placement alone for malignant biliary obstruction

Cited by 2 publications

References 0 publications

Radiofrequency Ablation Combined with Stent Placement versus Stent Placement Alone for Malignant Biliary Obstruction: A Systematic Review and Meta-analysis

Radiofrequency Ablation Combined with Stent Placement versus Stent Placement Alone for Malignant Biliary Obstruction: A Systematic Review and Meta-analysis

Comparison of Intraductal RFA Plus Stent versus Stent-Only Treatment for Unresectable Perihilar Cholangiocarcinoma—A Systematic Review and Meta-Analysis

Contact Info

Product

Resources

About